서울대학교 의과대학 임상약리학교실

Considerations for clinical evaluation of the effects of bariatric surgery on the pharmacokinetics of orally administered drugs

Sungyeun Bae, JungJin Oh, Ildae Song, Kyung-Sang Yu, SeungHwan Lee

Translational and clinical pharmacology. 2022,Sep;30(3):145-154. doi: 10.12793/tcp.2022.30.e15. Epub 2022 Sep 26.

Effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of lacosamide in Korean patients with epilepsy

Seon-Jae Ahn, Jaeseong Oh, Do-Yong Kim, Hyoshin Son, Sungeun Hwang, Hye-Rim Shin, Eun Young Kim, Han Sang Lee, Woo-Jin Lee, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, Sang Kun Lee

EPILEPSIA 2022,Aug; Aug 21. doi: 10.1111/epi.17399. Online ahead of print.

Night-time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole

Eunsol Yang, Seokuee Kim, Bongtae Kim, Boram Kim, Yechan Kim, Sung Sup Park, Geun Seog Song, Kyung-Sang Yu, In-Jin Jang, Seung Hwan Lee

British journal of clinical pharmacology. 2022,Jul;;88(7):3288-3296. doi: 10.1111/bcp.15268. Epub 2022 Feb 23.

Clinical Evaluation of Digital Therapeutics: Present and Future

Ki Young Huh, Jaeseong Oh, SeungHwan Lee, Kyung-Sang Yu

Healthcare informatics research. 2022,Jul;Jul;28(3):188-197. doi: 10.4258/hir.2022.28.3.188. Epub 2022 Jul 31.

The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects

Sejung Hwang, Soyoung Lee, Eunwoo Kim, Inyoung Hwang, Joo-Youn Cho , Jae-Yong Chung, In-Jin Jang, Jaeseong Oh

Clinical and translational science. 2022,Jun; Jun 21. doi: 10.1111/cts.13344. Online ahead of print.

A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808

Tae Kyu Chung, Hyun A Lee, Kyeong-Ryoon Lee, Seong Bok Jang, Kyung-Sang Yu, Howard Lee

CPT: pharmacometrics & systems pharmacology. 2022,Jun;Jun 24. doi: 10.1002/psp4.12839. Online ahead of print.

Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination

Hyun Chul Kim, Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Jang Hee Hong, JaeWoo Kim

Translational and clinical pharmacology. 2022,Jun;Jun;30(2):112-119. doi: 10.12793/tcp.2022.30.e12. Epub 2022 Jun 27.

Key Considerations for Phase 2 or 3 Clinical Study Design of Anti-Inflammatory Agent for COVID-19 Treatment

Yewon Park, Joo Young Na, Joo-Youn Cho, Jaeseong Oh, Su-Jin Rhee

Frontiers in pharmacology. 2022,Jun;Jun 2;13:842836. doi: 10.3389/fphar.2022.842836. eCollection 2022.

An Improved Method to Quantify Short-Chain Fatty Acids in Biological Samples Using Gas Chromatography-Mass Spectrometry

Kyeong-Seog Kim, Yujin Lee, Woori Chae, Joo-Youn Cho

Metabolites 2022,Jun;Jun 7;12(6):525. doi: 10.3390/metabo12060525.

Therapeutic drug monitoring on the use of transplacental digoxin in fetal tachyarrhythmia: a case report

Sae Im Jeong, Heejae Won, Ildae Song, Jaeseong Oh

Translational and clinical pharmacology. 2022,Jun;Jun;30(2):83-86. doi: 10.12793/tcp.2022.30.e11. Epub 2022 Jun 22.

Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase

Jihyun Kang, Andrew HyoungJin Kim, Inseung Jeon, Jaeseong Oh, In-Jin Jang, SeungHwan Lee, Joo-Youn Cho

Clinical and translational science. 2022,May; May;15(5):1104-1111. doi: 10.1111/cts.13203. Epub 2021 Dec 4.

Comparative Pharmacokinetics Between a Fixed-Dose Combination of Pitavastatin/Valsartan 4/160 mg and the Corresponding Individual Components Through a Partial Replicated Crossover Design in Healthy Male Subjects

Joo Young Na, Eunsol Yang, Jae-Hoon Kim, In Sun Kwon, Eun-Heui Jin, Kyung-Sang Yu, Jinsook Kim, SeungHwan Lee, Jang Hee Hong

Clinical pharmacology in drug development. 2022,May;;11(5):615-622. doi: 10.1002/cpdd.1054. Epub 2022 Jan 8.

Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension

Su-Jin Rhee, Seung Han Shin, Jaeseong Oh, Young Hwa Jung, Chang Won Choi, Han-Suk Kim, Kyung-Sang Yu

Scientific Reports 2022,May;May 5;12(1):7393. doi: 10.1038/s41598-022-11038-6.

Dose-dependent glucosuria of DWP16001, a novel selective sodium-glucose cotransporter-2 inhibitor, in healthy subjects

Jun Gi Hwang, SeungHwan Lee, Wan Huh, Jumi Han, Jaeseong Oh, In-Jin Jang, Kyung-Sang Yu

British journal of clinical pharmacology 2022,Apr;Apr 8. doi: 10.1111/bcp.15348. Online ahead of print.

Single-dose of LC51-0255, a selective S1P 1 receptor modulator, showed dose-dependent and reversible reduction of absolute lymphocyte count in humans

Sang Won Lee, Inyoung Hwang, Jaeseong Oh, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Clinical and translational science 2022,Apr;Apr;15(4):1074-1083. doi: 10.1111/cts.13227. Epub 2022 Jan 23.

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

Mary Beth Wire, Soo Youn Jun, In-Jin Jang, Seung-Hwan Lee, Jun Gi Hwang, David B Huang

Antimicrobial agents and chemotherapy 2022,Mar;2022 Mar 15;66(3):e0184221. doi: 10.1128/AAC.01842-21. Epub 2022 Jan 10.

Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects

Yewon Park, WonTae Jung, Eunsol Yang, Kyu-Yeol Nam, Woo-Ri Bong, Jaehee Kim, Kyu Yeon Kim, SeungHwan Lee, Joo-Youn Cho, Jang-Hee Hong, JaeWoo Kim

Translational and clinical pharmacology. 2022,Mar; Mar;30(1):49-56. doi: 10.12793/tcp.2022.30.e3. Epub 2022 Mar 7.

Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series

Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo-Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung-Don Oh, Nam Joong Kim

Translational and clinical pharmacology. 2022,Mar;Mar;15(3):732-740. doi: 10.1111/cts.13194. Epub 2021 Nov 20.

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non-Japanese

Eunsol Yang, Jung Sunwoo, Ki Young Huh, Yu Kyong Kim, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Clinical and translational science. 2022,Feb;15(2):490-500. doi: 10.1111/cts.13167. Epub 2021 Oct 20.

A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults

Jihyun Jung, Ki Young Huh, Xuanyou Jin, Ahnul Ha, Ki Ho Park, Jun Sang Park, Eunjung Kim, Jaehwi Lee, In-Jin Jang, Howard Lee

Clinical and translational science. 2022,Feb; Feb;15(2):343-352. doi: 10.1111/cts.13150. Epub 2021 Sep 15.

Pharmacokinetics and safety of a novel influenza treatment (baloxavir marboxil) in Korean subjects compared with Japanese subjects

Yun Kim, Sangwon Lee, Yohan Kim, In-Jin Jang, SeungHwan Lee

Clinical and translational science. 2022,Feb; Feb;15(2):422-432. doi: 10.1111/cts.13160. Epub 2021 Oct 19.

Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects

Joo Young Na, Ki Young Huh, Kyung-Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You , Jae-Yong Chung

Clinical and translational science. 2022,Feb; 8. doi: 10.1111/cts.13226. Online ahead of print.

An annotated corpus from biomedical articles to construct a drug-food interaction database

Siun Kim, Yoona Choi, Jung-Hyun Won, Jung Mi Oh, Howard Lee

Journal of biomedical informatics. 2022,Feb;126:103985. doi: 10.1016/j.jbi.2022.103985. Epub 2022 Jan 7.

Evaluation of safety and pharmacokinetics of bismuth-containing quadruple therapy with either vonoprazan or lansoprazole for Helicobacter pylori eradication

Ki Young Huh, Hyewon Chung, Yu Kyong Kim, Seung Hwan Lee, Siddharth Bhatia, Yohei Takanami, Ryou Nakaya, Kyung-Sang Yu

British journal of clinical pharmacology. 2022,Jan;88(1):138-144. doi: 10.1111/bcp.14934. Epub 2021 Jun 26.

Pharmacokinetic and Pharmacodynamic Characteristics of Tripegfilgrastim, a Pegylated G-CSF, in Pediatric Patients with Solid Tumors

Soyoung Lee, Kyung Taek Hong, Seol Ju Moon, Jung Yoon Choi, Che Ry Hong, Hee Young Shin, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jaeseong Oh, Hyoung Jin Kang

Clinical pharmacology and therapeutics. 2022,Jan;2022 Jan;111(1):293-301. doi: 10.1002/cpt.2433.

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

Bonah Kim, Hee Young Kim, Bo Ruem Yoon, Jina Yeo, Ji In Jung, Kyung-Sang Yu 5, Hyeon Chang Kim, Su-Jin Yoo, Jin Kyun Park, Seong Wook Kang, Won-Woo Lee

Science signaling. 2022,Jan;11;15(716):eabi7400. doi: 10.1126/scisignal.abi7400. Epub 2022 Jan 11.

Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components

Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung

Clinical pharmacology in drug development. 2022,Jan;11(1):91-99. doi: 10.1002/cpdd.963. Epub 2021 Jun 22.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects

Yoomin Jeon, Nora Lee, Seungjae Baek, JaeDuk Choi, Stanford Jhee, Howard Lee

Drugs in R&D. 2022,Jan;6. doi: 10.1007/s40268-021-00379-8. Online ahead of print.