Population pharmacokinetic analysis of zastaprazan (JP-1366), a novel potassium-competitive acid blocker, in patients and healthy volunteers

Eunsol Yang, Inyoung Hwang, Sang Chun Ji, John Kim, SeungHwan Lee

CPT Pharmacometrics Syst Pharmacol 2024,Dec;13(12):2150-2158. doi: 10.1002/psp4.13228. Epub 2024 Sep 13.

Population pharmacokinetic model of ABL001/CTX-009 (antiVEGF/DLL4) in adult cancer patients with solid tumor

Joo Young Na, Juyeun Jeon, Ki Young Huh, Kyung-Sang Yu, Sangmi Lee, Jaehyun Eom, Jinhyung Ahn, Weon-Kyoo You, Jaeseong Oh

Cancer Sci 2024,Dec;115(12):3943-3951. doi: 10.1111/cas.16363. Epub 2024 Oct 7.

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi-physiologic population pharmacokinetic approach

Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung-Sang Yu, SeungHwan Lee

Clin Transl Sci 2024,Dec;17(12):e70103. doi: 10.1111/cts.70103.

Analyzing collaborations in clinical trials in Korea using association rule mining

Ki Young Huh, Ildae Song

Translational and clinical pharmacology. 2024,Dec;32(4):177-186. doi: 10.12793/tcp.2024.32.e17. Epub 2024 Dec 16.

Oncological outcomes after radical prostatectomy of localized prostate cancer: stratified by magnetic resonance imaging and risk classification

Gyoohwan Jung, Byeongdo Song, Hyungwoo Ahn, Sung Il Hwang, Hak Jong Lee, Ki Young Huh, Sang Hun Song, Sangchul Lee, Seok-Soo Byun, Sung Kyu Hong

Prostate Int 2024,Dec;12(4):224-230. doi: 10.1016/j.prnil.2024.09.003. Epub 2024 Sep 28.

Comparative pharmacokinetics study of two tablet formulations of delpazolid, a novel oxazolidinone class antibiotic

JaeEun Koh, Juyoung Khwarg, Young Lag Cho, Kyung-Sang Yu, Jae-Yong Chung

Transl Clin Pharmacol 2024,Dec;32(4):216-224. doi: 10.12793/tcp.2024.32.e18. Epub 2024 Dec 18.

Population pharmacokinetic and pharmacodynamic model guided weight-tiered dose of AST-001 in pediatric patients with autism spectrum disorder

Soyoung Lee, Su-Kyeong Hwang, Jung-Sook Cho, Hyung Chul Ryu, Jae-Yong Chung

Front Pharmacol 2024,Dec;15:1452526. doi: 10.3389/fphar.2024.1452526. eCollection 2024.

Phase 1 study of AYP-101 (soybean phosphatidylcholine): safety, pharmacokinetics, and lipid profile effects for reducing submental fat

Hyun Joon Lee, Xu Jiang, A M Abd El-Aty, Ji Hoon Jeong, Jae-Yong Chung

Lipids Health Dis 2024,Dec;23(1):426. doi: 10.1186/s12944-024-02387-4.

Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole

Yoonjin Kim, Sungyeun Bae, Inseung Jeon, Jihoon Kwon, Sung Hee Hong, Na Young Kim, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Clin Ther 2024,Nov;46(11):870-876. doi: 10.1016/j.clinthera.2024.08.006. Epub 2024 Sep 16.

Prospective phase II study of allogeneic hematopoietic stem cell transplantation with targeted busulfan, fludarabine, and etoposide conditioning in pediatric acute lymphoblastic leukemia

Kyung Taek Hong, Hyun Jin Park, Bo Kyung Kim, Jung Yoon Choi, Sang Hoon Song, SeungHwan Lee Kyung-Sang Yu, In-Jin Jang, Hyoung Jin Kang

Hemasphere 2024,Nov;8(12):e70051. doi: 10.1002/hem3.70051. eCollection 2024 Dec.

Development of a Diagnostic IgM Antibody Capture ELISA for Detection of Anti-Cache Valley Virus Human IgM

Christin Goodman, Jordan A Powers, Sierra R Mikula, Holly R Hughes, Brad J Biggerstaff, Kelly Fitzpatrick, Amanda J Panella, Carlos Machain-Williams, SeungHwan Lee, Amanda E Calvert

Am J Trop Med Hyg 2024,Nov;112(2):386-395. doi: 10.4269/ajtmh.24-0360. Print 2025 Feb 5.

Effect of Narrowband Ultraviolet B Phototherapy on Systemic Metabolome in Korean Patients With Psoriasis

Yufei Li, Yujin Lee, Howard Lee, Seong-Jin Jo, Joo-Youn Cho

Exp Dermatol 2024,Oct;2024 Oct;33(10):e15192. doi: 10.1111/exd.15192.

Intravitreal long-term sustained ranibizumab delivery using injectable microgel-embedded hydrogel

Simin Lee, Jun Young Park, Hye Kyoung Hong, Joo Young Son, Byungwook Kim, Jae Yong Chung, Se Joon Woo, Ki Dong Park

Asian J Pharm Sci 2024,Oct;19(5):100947. doi: 10.1016/j.ajps.2024.100947. Epub 2024 Aug 8.

Comprehensive Evaluation of OATP- and BCRP-Mediated Drug-Drug Interactions of Methotrexate Using Physiologically-Based Pharmacokinetic Modeling

Sejung Hwang, Yujin Lee, Yeonseo Jang, Joo-Youn Cho, Seonghae Yoon, Jae-Yong Chung

Clin Pharmacol Ther 2024,Oct;116(4):1013-1022. doi: 10.1002/cpt.3329. Epub 2024 Jun 11.

Population Pharmacokinetic Modeling and Simulation for Dose Optimization of GB-5001, a Long-Acting Intramuscular Injection of Donepezil, in Healthy Participants

Juyoung Khwarg, Heeyong Lee, Kyung-Sang Yu, Eunyoung Seol, Jae-Yong Chung

Neurol Ther 2024,Oct;13(5):1453-1466. doi: 10.1007/s40120-024-00643-4. Epub 2024 Aug 10.

Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose riliprubart, an anti-C1s humanized monoclonal antibody in East-Asian adults: results from a Phase 1, randomized, open-label trial

Yingxin Li, Joo Young Na, Yunting Zhu, Jaeseong Oh, Amy Zhao, In-Jin Jang, Lei Tang

Expert Opin Investig Drugs 2024,Oct;33(10):1063-1074. doi: 10.1080/13543784.2024.2394186. Epub 2024 Aug 22.

Erratum: Real-World Application of Artificial Intelligence for Detecting Pathologic Gastric Atypia and Neoplastic Lesions.

Young Hoon Chang, Cheol Min Shin, Hae Dong Lee, Jinbae Park, Jiwoon Jeon, Soo-Jeong Cho, Seung Joo Kang, Jae-Yong Chung, Yu Kyung Jun, Yonghoon Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee

J Gastric Cancer 2024,Oct;24(4):480. doi: 10.5230/jgc.2024.24.e33.

Author Correction: A randomized study to evaluate the safety and immunogenicity of a pentavalent meningococcal vaccine

Yoonjin Kim, Sungyeun Bae, Kyung-Sang Yu, SeungHwan Lee, Chankyu Lee, Jinil Kim, Howard Her, Jaeseong Oh

NPJ Vaccines 2024,Sep;9(1):175. doi: 10.1038/s41541-024-00965-2.

Pharmacokinetics-Based Safety Evaluation in Half-Dose Verteporfin Photodynamic Therapy

Hyeong Min Kim, Hyuncheol Kim, Jae Yong Chung, Se Joon Woo

Ophthalmic Res 2024,Sep;67(1):594-599. doi: 10.1159/000541619. Epub 2024 Sep 26.

Individual pharmacokinetic parameter estimation of gentamicin in an obese hemodialysis patient using non-linear mixed effect model

Hyoeun Lee, Seonghae Yoon, Jae Yong Chung

Transl Clin Pharmacol 2024,Sep;32(3):150-158. doi: 10.12793/tcp.2024.32.e14. Epub 2024 Sep 25.

Impact of antibiotic changes on hospital stay and treatment duration in community-acquired pneumonia

Jiwon Ryu, Nak-Hyun Kim, Jung Hun Ohn, Yejee Lim, Jongchan Lee, Hye Won Kim, Sun-Wook Kim, Hee-Sun Park, Eu Suk Kim, Seonghae Yoon, Eunjeong Heo, Eun Sun Kim

Sci Rep 2024,Sep;14(1):22669. doi: 10.1038/s41598-024-73304-z.

Exploration of pharmacokinetic differences between East Asians and Caucasians: insights from pharmacokinetic studies in healthy subjects

Yoonjin Kim, Sungyeun Bae, Woo Kyung Chung, Jihoon Kwon, Ildae Song, SeungHwan Lee

Transl Clin Pharmacol 2024,Sep;32(3):127-136. doi: 10.12793/tcp.2024.32.e15. Epub 2024 Sep 30.

The Cost Effectiveness of Adjunctive Treatments for Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease

Ulysses S Rosas, Christopher V Almario, Kyung-Sang Yu, Brennan M R Spiegel

Clin Drug Investig 2024,Sep;44(9):703-714. doi: 10.1007/s40261-024-01387-7. Epub 2024 Sep 7.

A randomized study to evaluate the safety and immunogenicity of a pentavalent meningococcal vaccine

Yoonjin Kim, Sungyeun Bae, Kyung-Sang Yu, SeungHwan Lee, Chankyu Lee, Jinil Kim, Howard Her, Jaeseong Oh

NPJ Vaccines 2024,Aug;9(1):140. doi: 10.1038/s41541-024-00935-8.

Metabolic profiling of psoriasis vulgaris and palmoplantar pustulosis

Yujin Lee, Seong Rae Kim, Mu Seong Ban, Howard Lee, Joo-Youn Cho, Seong Jin Jo

Exp Dermatol 2024,Aug;2024 Aug;33(8):e15159. doi: 10.1111/exd.15159.

Nasal symbiont Staphylococcus epidermidis restricts influenza A virus replication via the creation of a polyamine-deficient cellular environment

Ara Jo, Kyeong-Seog Kim, Jina Won, Haeun Shin, Sujin Kim, Bora Kim, Da Jung Kim, Joo-Youn Cho, Hyun Jik Kim

Commun Biol 2024,Aug;2024 Aug 22;7(1):1031. doi: 10.1038/s42003-024-06706-4.

Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway

Yeon Jun Kang, Woorim Song, Su Jeong Lee, Seung Ah Choi, Sihyun Chae, Bo Ruem Yoon, Hee Young Kim, Jung Ho Lee, Chulwoo Kim, Joo-Youn Cho, Hyun Je Kim, Won-Woo Lee

Exp Mol Med 2024,Aug;56(8):1776-1790. doi: 10.1038/s12276-024-01286-z. Epub 2024 Aug 1.

Pharmacokinetics and safety of candidate tocilizumab biosimilar CT-P47 administered by auto-injector or pre-filled syringe: a randomized, open‑label, single-dose phase I study

Kyung-Sang Yu, Hyunwook Ryu, Dongseong Shin, MinKyu Park, JunGi Hwang, Seol Ju Moon, Min-Gul Kim, Edward Keystone, Josef S Smolen, SungHyun Kim, YunJu Bae, DaBee Jeon, JiYoung Jang, GoEun Yang, JiHun Bae, JaeYong Lee, Gerd R Burmester

Expert Opin Biol Ther 2024,Jul;24(7):681-689. doi: 10.1080/14712598.2024.2321360. Epub 2024 Jun 21.

The effect of renal function on the pharmacokinetics and pharmacodynamics of enavogliflozin, a potent and selective sodium-glucose cotransporter-2 inhibitor, in type 2 diabetes

Sae Im Jeong, Mu Seong Ban, Jun-Gi Hwang, Min-Kyu Park, Soo Lim, Sejoong Kim, Soon Kil Kwon, Yoonjin Kim, Jae Min Cho, Jae Jin Na, Wan Huh, Jae-Yong Chung

Diabetes Obes Metab 2024,Jul;26(7):2588-2597. doi: 10.1111/dom.15573. Epub 2024 Apr 15.

Pharmacokinetic Interactions Between the Fixed-Dose Combination of Ezetimibe/Rosuvastatin 10/20 Mg and the Fixed-Dose Combination of Telmisartan/Amlodipine 80/5 Mg in Healthy Subjects

Hyunwook Ryu, Hyun Chul Kim, Inseung Jeon, In-Jin Jang, Joo-Youn Cho, Kyung Tae Kim, Jaeseong Oh

Drug Des Devel Ther 2024,Jul;18:2641-2652. doi: 10.2147/DDDT.S465652. eCollection 2024.

Real-World Application of Artificial Intelligence for Detecting Pathologic Gastric Atypia and Neoplastic Lesions

Young Hoon Chang, Cheol Min Shin, Hae Dong Lee, Jinbae Park, Jiwoon Jeon, Soo-Jeong Cho, Seung Joo Kang, Jae-Yong Chung, Yu Kyung Jun, Yonghoon Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee

J Gastric Cancer 2024,Jul;24(3):327-340. doi: 10.5230/jgc.2024.24.e28.

Pharmacokinetic drug-drug interactions of JBPOS0101 mediated by cytochrome P450 3A4 and UDP-glucuronosyltransferases

Sejung Hwang, Yong Moon Choi, Myoung-Seok Kim, SeungHwan Lee

Clin Transl Sci 2024,Jul;17(7):e13892. doi: 10.1111/cts.13892.

Pharmacokinetic interactions between fexuprazan, a potassium-competitive acid blocker, and nonsteroidal anti-inflammatory drugs in healthy males

Heejae Won, Eunwoo Kim, Jihye Chae, Hyejung Lee, Joo-Youn Cho, In-Jin Jang, Jae-Yong Chung, Min-Gul Kim, SeungHwan Lee

Clin Transl Sci 2024,May;17(5):e13798. doi: 10.1111/cts.13798.

Pioglitazone-induced alterations of purine metabolism in healthy male subjects

Jihyun Kang, Yufei Li, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho

Clin Transl Sci 2024,May;17(5):e13834. doi: 10.1111/cts.13834

Targeted Metabolomic Biomarkers for Stroke Subtyping

Eung-Joon Lee, Da Jung Kim, Dong-Wan Kang, Wookjin Yang, Han-Yeong Jeong, Jeong-Min Kim, Sang-Bae Ko, Seung-Hoon Lee, Byung-Woo Yoon, Joo-Youn Cho, Keun-Hwa Jung

Translational stroke research. 2024,Apr;15(2):422-432. doi: 10.1007/s12975-023-01137-5. Epub 2023 Feb 11.

Pharmacokinetics, pharmacodynamics and safety of oral formulation (CG-750) of ivaltinostat, a histone deacetylase inhibitor, compared to IV formulation (CG-745)

Byungwook Kim, Ki Young Huh, Kyung-Sang Yu, SeungHwan Lee

British journal of clinical pharmacology. 2024,Apr;90(4):1103-1114. doi: 10.1111/bcp.15997. Epub 2024 Jan 23.

A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects

Xu Jiang, Kyung-Sang Yu, Dong Hyuk Nam, Jaeseong Oh

Pharmaceuticals (Basel) 2024,Apr;17(4):522. doi: 10.3390/ph17040522.

Safety, Tolerability, and Pharmacokinetics of a Novel Macrocyclic Gadolinium-Based Contrast Agent, HNP-2006, in Healthy Subjects

Ki Young Huh, Woo Kyung Chung, Heejeong Lee, Seung Hong Choi, Kyung-Sang Yu, SeungHwan Lee

Investigative radiology. 2024,Mar;1;59(3):252-258.

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity

Jihoon G Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon, Dai Hoon Han, Jaeseong Oh, In-Jin Jang, Sang-Hoon Kim, Young-Koo Jee, Hyun Lee, Dong Won Park, Jang Won S

Experimental & molecular medicine. 2024,Mar;56(3):570-582. doi: 10.1038/s12276-024-01172-8. Epub 2024 Mar 1.

Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 ( Lactococcus lactis) administration

Min-Gul Kim, Suin Kim, Ji-Young Jeon, Seol Ju Moon, Yong-Geun Kwak, Joo Young Na, SeungHwan Lee, Kyung-Mi Park, Hyo-Jin Kim, Sang-Min Lee, Seo-Yeon Choi, Kwang-Hee Shin

Korean J Physiol Pharmacol. 2024,Mar; 1;28(2):153-164. doi: 10.4196/kjpp.2024.28.2.153.

Effects of meal type on the bioavailability of vutiglabridin, a novel anti-obesity agent, in healthy subjects

Heejae Won, Deok Yong Yoon, Sangmi Lee, Joo-Youn Cho, Jaeseong Oh, In-Jin Jang, Sang-Ku Yoo, Kyung-Sang Yu

Clin Transl Sci 2024,Mar;17(3):e13744. doi: 10.1111/cts.13744.

Estimation of the benefit from pre-emptive genotyping based on the nationwide cohort data in South Korea

Ki Young Huh, Sejung Hwang, Joo Young Na, Kyung-Sang Yu, In-Jin Jang, Jae-Yong Chung, Seonghae Yoon

Clin Transl Sci 2024,Mar;17(3):e13772. doi: 10.1111/cts.13772.

Establishment of Advanced Regulatory Innovation for Clinical Trials Transformation (ARICTT): a multi-stakeholder public-private partnership-based organization to accelerate the transformation of clinical trials

Woo Kyung Chung, Ki Young Huh, Jiyeon Park, Jaeseong Oh, Kyung-Sang Yu

Transl Clin Pharmacol 2024,Mar;32(1):30-40. doi: 10.12793/tcp.2024.32.e1. Epub 2024 Feb 20.

The landscape of decentralized clinical trials (DCTs): focusing on the FDA and EMA guidance

Jiyeon Park, Ki Young Huh, Woo Kyung Chung, Kyung-Sang Yu

Transl Clin Pharmacol 2024,Mar;32(1):41-51. doi: 10.12793/tcp.2024.32.e2. Epub 2024 Feb 20.

Topiramate dosage optimization for effective antiseizure management via population pharmacokinetic modeling

Seolah Lee, Hyun Chul Kim, Yoonhyuk Jang, Han Sang Lee, Seon-Jae Ahn, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Jaeseong Oh, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Soyoung Lee, Kon Chu, Sang Kun Lee

Annals of clinical and translational neurology. 2024,Feb;11(2):424-435. doi: 10.1002/acn3.51962. Epub 2023 Dec 7.

Evaluation of Food Effect on the Pharmacokinetics of Velufenacin, a New Muscarinic Receptor Antagonist, in Healthy Subjects

Juyoung Khwarg, Woo Kyung Chung, Soyoung Lee, Eunsol Yang, Chaelim Ryu, Dae Young Lee, Min Jung Lee, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Clinical pharmacology in drug development. 2024,Feb;13(2):128-133. doi: 10.1002/cpdd.1361. Epub 2023 Dec 29.

Effects of food and ethnicity on the pharmacokinetics of venadaparib, a next-generation PARP inhibitor, in healthy Korean, Caucasian, and Chinese male subjects

Hyun Chul Kim, Eunsol Yang, Soyoung Lee, Jaeseong Oh, Myongjae Lee, ChaeEun Lee, Kyoung Soo Ha, Won Sik Lee, In-Jin Jang, Kyung-Sang Yu

Investigational new drugs. 2024,Feb;42(1):80-88. doi: 10.1007/s10637-023-01405-z. Epub 2023 Dec 15.

Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects

Juyoung Khwarg, Soyoung Lee, In-Jin Jang, Won-Ho Kang, Hye Jung Lee, Kyu Yeon Kim, Ki-Sun Jeong, Chongho Won, Youn Woong Choi, Dae Chul Ha, RaeHoon Jung, Min-Gu Han, Won Tae Jung, Kyu-Yeol Nam, YeSeul Kim, Kyung-Sang Yu, Jaeseong Oh

Drug design, development and therapy. 2024,Feb;8:18:395-406.

Pharmacogenetic Analysis of an 8-Year Old Girl with Reye Syndrome Associated with Use of Naproxen

Byungwook Kim, Joo-Youn Cho, Ildae Song, Jaeseong Oh

The American journal of case reports. 2024,Feb;5:25:e942242. doi: 10.12659/AJCR.942242.

Differences in Brain Metabolite Profiles Between Normothermia and Hypothermia

Suk Ho Sohn, Sihyun Chae, Jae Woong Choi, Karam Nam, Youn Joung Cho, Joo-Youn Cho, Ho Young Hwang

Journal of Korean medical science. 2024,Feb;26;39(7):e79. doi: 10.3346/jkms.2024.39.e79.

Metabolomic Characteristics of Nontuberculous Mycobacterial Pulmonary Disease

Jungeun Kim, Woori Chae, Joong-Yub Kim, Jae-Joon Yim, Joo-Youn Cho, Nakwon Kwak

J Infect Dis 2024,Feb;doi: 10.1093/infdis/jiae100. Online ahead of print.

A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea

JooYong Park, Jaemyung Kim, Jihyun Kang, Jaesung Choi, Ji-Eun Kim, Kyung-Joon Min, Seong-Woo Choi, Joo-Youn Cho, Miyoung Lee, Ji-Yeob Choi

BMC sports science, medicine and rehabilitation 2024,Jan;29;16(1):30. doi: 10.1186/s13102-024-00824-6.