서울대학교 의과대학 임상약리학교실

Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients with Hematologic Malignancies.

Suh HJ, Kim I, Cho JY, Park SI, Yoon SH, Hwang JH, Bae JY, Lee JO, Koh Y, Song KH, Choe PG, Yu KS, Kim ES, Kim HB, Bang SM, Kim NJ, Oh MD, Song SH, Park WB

Ther Drug Monit 2017,Nov;10.1097/FTD.0000000000000469. [Epub ahead of print]

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials.

Kim S,Lee S, Cho JY, Yoon SH, Jang IJ, Yu KS,

Drug Des Devel Ther 2017,Nov;7;11:3187-3195.

Performance of the Minto model for the target-controlled infusion of remifentanil during cardiopulmonary bypass.

Cho YJ, Jo WY, Oh H, Koo CH, Oh J, Cho JY, Yu KS, Jeon Y, Kim TK

Anaesthesia 2017,Oct;72(10):1196-1205. doi: 10.1111/anae.14019.

Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers.

Yoon S, Rhee SJ, Heo SJ, Oh TY, Yoon SH, Cho JY, Lee S, Yu KS.

Drug Des Devel Ther 2017,Oct;27;11:3127-3135.

Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct.

Lee H, Lee H, Baik J, Kim H, Kim R.

Drug Des Devel Ther 2017,Oct;19;11:3035-3043.

Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate After Single-dose Administration in Healthy Korean Male Subjects.

Kim Y, Kim A, Lee S, Choi SH, Lee DY, Song JS, Lee H, Jang IJ, Yu KS

Clin Ther 2017,Sep;39(9):1849-1857. doi: 10.1016/j.clinthera.2017.08.002. Epub 2017 Aug 31.

New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients.

Kim YK, Kim A, Park SJ, Lee H.

Drug Des Devel Ther 2017,Sep;28;11:2861-2869.

Integrative Analysis of Renal Ischemia/Reperfusion Injury and Remote Ischemic Preconditioning in Mice.

Cho K, Min SI, Ahn S, Min SK, Ahn C, Yu KS, Jang IJ, Cho JY, Ha J.

J Proteome Res 2017,Aug;16(8):2877-2886. doi: 10.1021/acs.jproteome.7b00167. Epub 2017 Jul 3.

Risk factors for suboptimal drug concentration of posaconazole oral suspension in patients with hematologic malignancy.

Kim EJ, Yu KS, Na SH, Nam EY, Oh HS, Kim M, Yoon SH, Lee JO, Koh Y, Song KH, Choe PG, Cho JY, Song SH, Kim ES, Kim HB, Bang SM, Kim NJ, Oh MD, Kim I, Park WB.

J Mycol Med 2017,Aug;pii: S1156-5233(17)30102-6. doi: 10.1016/j.mycmed.2017.08.001. [Epub ahead of print]

Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs.

Joo K, Park SJ, Choi Y, Lee JE,, Na YM, Hong HK, Park KH, Kim HM, Chung JY, Woo SJ

Invest Ophthalmol Vis Sci 2017,Aug;58(10):4261-4267. doi: 10.1167/iovs.17-21813.

Correction: GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism.

Na YR, Gu GJ, Jung D, Kim YW, Na J, Woo JS, Cho JY, Youn H, Seok SH.

J Immunol 2017,Aug;198(7):3000. doi: 10.4049/jimmunol.1700174.

A novel K+ competitive acid blocker, YH4808, sustains inhibition of gastricacid secretion with a faster onset than esomeprazole: randomised clinicalstudy in healthy volunteers.

Yi S, Lee H, Jang SB, Byun HM, Yoon SH, Cho JY, Jang IJ, Yu KS

Alimentary pharmacology & therapeutics. 2017,Aug;46(3):337-346.

The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein.

Kim TE, Shin D, Gu N, Jung BH, Kim J, Cho YM, Yu KS, Cho JY.

Basic Clin Pharmacol Toxicol 2017,Jul;121(3):195-201. doi: 10.1111/bcpt.12826. Epub 2017 Jul 10.

LBEC0101, A Proposed Etanercept Biosimilar: Pharmacokinetics, Immunogenicity, and Tolerability Profiles Compared with a Reference Biologic Product in Healthy Male Subjects.

Lee H, Chung H, Lee S, Lee H, Yang SM, Yoon SH, Cho JY, Jang IJ, Yu KS.

BioDrugs 2017,Jul;doi: 10.1007/s40259-017-0230-9. [Epub ahead of print]

Pediatric patients undergoing hematopoietic stem cell transplantation can greatly benefit from a novel once-daily intravenous busulfan dosing nomogram.

Rhee SJ, Lee JW, Yu KS, Hong KT, Choi JY, Hong CR, Park KD, Shin HY, Song SH, Kang HJ, Lee H

Am. J. Hematol. 2017,Jul;92(7):607-613. doi: 10.1002/ajh.24734. Epub 2017 May 30.

Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea.

Choi YJ, Kim N, Jang IJ, Cho JY, Nam RH, Park JH, Jo HJ, Yoon H, Shin CM, Park YS, Lee DH, Jung HC

Gut Liver 2017,Jul;11(4):504-511. doi: 10.5009/gnl16352.

Plasma LTE4/PGF2α Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation.

Ban GY, Ye YM, Kim SH, Hur GY, Kim JH, Shim JJ, Cho K, Cho JY, Park HS; PRANA group.

Allergy Asthma Immunol Res 2017,Jul;9(4):378-382. doi: 10.4168/aair.2017.9.4.378.

Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females.

Lee J, Kim AH, Yi S, Lee S, Yoon SH, Yu KS, Jang IJ, Cho JY

AAPS J 2017,Jul;19(4):1196-1204. doi: 10.1208/s12248-017-0090-8. Epub 2017 May 18.

Prediction of serum theophylline concentrations and CYP1A2 activity by analyzing urinary metabolites in preterm infants

Sohn JA, Kim HS, Oh J, Cho JY, Yu KS, Lee J, Shin SH, Lee JA, Choi CW, Kim EK, Kim BI, Park EA.

Br J Clin Pharmacol 2017,Jun;83(6):1279-1286. doi: 10.1111/bcp.13211. Epub 2017 Jan 18.

Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies.

Suh HJ, Kim I, Cho JY, Park SI, Yoon SH, Lee JO, Koh Y, Song KH, Choe PG, Yu KS, Kim ES, Kim HB, Bang SM, Kim NJ, Song SH, Park WB, Oh MD

Infect Chemother 2017,Jun;49(2):135-139. doi: 10.3947/ic.2017.49.2.135. Epub 2017 Jun 9.

A Significant Influence of Metronidazole on Busulfan Pharmacokinetics: A Case Report of Therapeutic Drug Monitoring.

Chung H, Yu KS, Hong KT, Choi JY, Hong CR, Kang HJ, Park KD, Shin HY, Lee S.

Ther Drug Monit 2017,Jun;39(3):208-210. doi: 10.1097/FTD.0000000000000395.

High-Fat Diet and Voluntary Chronic Aerobic Exercise Recover Altered Levels of Aging-Related Tryptophan Metabolites along the Kynurenine Pathway.

Lee KJ, Jung KH, Cho JY, Lee ST, Kim HS, Shim JH, Lee SK, Kim M, Chu K

Exp Neurobiol 2017,Jun;26(3):132-140. doi: 10.5607/en.2017.26.3.132. Epub 2017 Jun 26.

Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD).

Kim HY, Yoo TH, Hwang Y, Lee GH, Kim B, Jang J, Yu HT, Kim MC, Cho JY, Lee CJ, Kim HC, Park S, Lee WW

Sci Rep 2017,Jun;7(1):3057. doi: 10.1038/s41598-017-03130-z.

Pharmacokinetic comparison using two tablets of an evogliptin/metformin XR 2.5/500 mg fixed dose combination vs. 1 tablet each of evogliptin 5 mg and metformin XR 1,000 mg
.

Yoon S, Rhee SJ, Park SI, Yoon SH, Cho JY, Jang IJ, Lee S, Yu KS.

Int J Clin Pharmacol Ther 2017,Jun;55(6):533-539. doi: 10.5414/CP202930.

Pharmacokinetics and Safety of a Single Dose of the Novel Necrosis Inhibitor LC28-0126 in Healthy Male Subjects

Seokuee Kim, Hyewon Chung, SeungHwan Lee, Sang-Heon Cho, Hyun-Jai Cho, Soon Ha Kim, In-Jin Jang, Kyung-Sang Yu

Br J Clin Pharmacol 2017,Jun;83(6):1205-1215. doi: 10.1111/bcp.13213. Epub 2017 Jan 25.

Korean Variant Archive (KOVA): a reference database of genetic variations in the Korean population.

Lee S, Seo J, Park J, Nam JY, Choi A, Ignatius JS, Bjornson RD, Chae JH, Jang IJ, Lee S, Park WY, Baek D, Choi M

Sci Rep 2017,Jun;7(1):4287. doi: 10.1038/s41598-017-04642-4.

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Jang K, Kim M, Oh J, Lee S, Cho J, Yu K, Choi T, Lee S, Lim K,

Drug Design, Development and Therapy 2017,May;11:705-711. doi: 10.2147/DDDT.S124307. eCollection 2017.

Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients.

Kim B, Lee JW, Hong KT, Yu KS, Jang IJ, Park KD, Shin HY, Ahn HS, Cho JY, Kang HJ.

Sci Rep 2017,May;7(1):1711. doi: 10.1038/s41598-017-01861-7.

Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches.

Lee J, Ji SC, Kim B, Yi S, Shin KH, Cho JY, Lim KS, Lee SH, Yoon SH, Chung JY, Yu KS, Park HS, Kim SH, Jang IJ

Clin Transl Sci 2017,May;10(3):163-171. doi: 10.1111/cts.12425. Epub 2016 Oct 26.

Characterization of ADME gene variation in 21 populations by exome sequencing.

Hovelson DH, Xue Z, Zawistowski M, Ehm MG, Harris EC, Stocker SL, Gross AS, Jang IJ, Ieiri I, Lee JE, Cardon LR, Chissoe SL, Abecasis G, Nelson MR

Pharmacogenet Genomics 2017,May;27(3):89-100. doi: 10.1097/FPC.0000000000000260.

Physiologically Based Pharmacokinetic Modelling and Prediction of Metformin Pharmacokinetics in Renal/Hepatic-Impaired Young Adults and Elderly Populations.

Rhee SJ, Chung H, Yi S, Yu KS, Chung JY.

Eur J Drug Metab Pharmacokinet 2017,May;doi: 10.1007/s13318-017-0418-x. [Epub ahead of print]

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects.

Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS

Drug Des Devel Ther 2017,May;11:713-723. doi: 10.2147/DDDT.S126861. eCollection 2017.

Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.

Jun SY, Jang IJ, Yoon S, Jang K, Yu KS, Cho JY, Seong MW, Jung GM, Yoon SJ, Kang SH.

Antimicrob Agents Chemother 2017,May;61(6). pii: e02629-16. doi: 10.1128/AAC.02629-16. Print 2017 Jun.

Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers.

Park S, Hyun YJ, Kim YR, Lee JH, Ryu S, Kim JM, Oh WY, Na HS, Lee JG, Seo DW, Hwang IY, Park Z, Jang IJ, Oh J, Choi SE

J Korean Med Sci 2017,May;32(5):729-736. doi: 10.3346/jkms.2017.32.5.729.

A randomized, double-blind, single-dose, two-arm, parallel study comparing pharmacokinetics, immunogenicity and tolerability of branded adalimumab and its biosimilar LBAL in healthy male volunteers.

Park KR, Chung H, Yang SM, Lee S, Yoon SH, Cho JY, Jang IJ, Yu KS

Expert Opin Investig Drugs 2017,May;26(5):619-624. doi: 10.1080/13543784.2017.1307339. Epub 2017 Mar 23.

A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET TM Plus platform

Y Choi, F Jiang, H An, H J Park, J H Choi, H Lee

Pharmacogenomics J . 2017,May;2017 Mar;17(2):174-179.

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans.

Oh J, Lee S, Lee H, Cho JY, Yoon SH, Jang IJ, Yu KS, Lim KS

PLoS ONE 2017,Apr;12(4):e0176320. doi: 10.1371/journal.pone.0176320. eCollection 2017.

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.

Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N.

Drug Des Devel Ther.  2017,Apr;11:1301-1313. doi: 10.2147/DDDT.S128727. eCollection 2017.

Targeted next-generation sequencing for comprehensive genetic profiling of pharmacogenes.

Han SM, Park J, Lee JH, Lee SS, Kim H, Han H, Kim Y, Yi S, Cho JY, Jang IJ, Lee MG

Clin Pharmacol Ther 2017,Mar;101(3):396-405

A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects.

Kim YK, Choi MJ, Oh TY, Yu KS, Lee S

Drug Des Devel Ther 2017,Mar;10;11:713-723.

Pharmacokinetic comparison and bioequivalence evaluation of two 10-mg baclofen formulations in healthy male subjects
.

Yoon S, Lee S, Yu KS, Yim SV, Kim BH.

Int J Clin Pharmacol Ther 2017,Feb;55(2):194-200. doi: 10.5414/CP202760.

Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel DPP-IV inhibitor, evogliptin (DA-1229).

Oh J, Kim AH, Lee S, Cho H, Kim YS, Bahng MY, Yoon SH, Cho JY, Jang IJ, Yu KS

Diabetes Obes Metab 2017,Feb;19(2):294-298. doi: 10.1111/dom.12813. Epub 2016 Nov 24.

Population pharmacokinetics and dose-response relationship of levetiracetam in adult patients with epilepsy.

Rhee SJ, Shin JW, Lee S, Moon J, Kim TJ, Jung KY, Park KI, Lee ST, Jung KH, Yu KS, Jang IJ, Chu K, Lee SK.

Epilepsy Res. 2017,Feb;132:8-14. doi: 10.1016/j.eplepsyres.2017.02.011. Epub 2017 Feb 27.

Changes in Cardiac Function After a Single Intravenous Administration of CKD-712 in Healthy Male Volunteers.

Park SI, Kim J, Yu KS, Jang IJ, Lee S.

Clin Drug Investig 2017,Feb;37(4):393-403. doi: 10.1007/s40261-017-0494-3.

An accelerator mass spectrometry-enabled microtracer study to evaluate the first-pass effect on the absorption of YH4808.

Kim A, Yu BY, Dueker SR, Shin KH, Kim HS, Ahn H, Cho JY, Yu KS, Jang IJ, Lee H

Clin Pharmacol Ther 2017,Feb;102(3):537-546. doi: 10.1002/cpt.672. Epub 2017 May 26.

Bioequivalence of two formulations of pregabalin 150-mg capsules under fasting conditions in healthy male subjects
.

Lee HA, Lee S, Yim SV, Kim BH.

Int J Clin Pharmacol Ther 2017,Feb;55(2):171-176.

Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults.

Chung H, Kim A, Lim KS, Park SI, Yu KS, Yoon SH, Cho JY, Chung JY.

Int Clin Psychopharmacol 2017,Jan;32(1):20-26.

Pharmacokinetic comparison of two formulations of talniflumate 370 mg tablets in healthy Korean volunteers


Kim Y, Yim S, Kim BH, Lee S.

Int J Clin Pharmacol Ther 2017,Jan;55(1):102-108. doi: 10.5414/CP202707.

Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.

Ban GY, Cho K, Kim SH, Yoon MK, Kim JH, Lee HY, Shin Y, Ye YM, Cho JY, Park HS

Clin. Exp. Allergy 2017,Jan;47(1):37-47.

Combined untargeted and targeted metabolomic profiling reveals urinary biomarkers for discriminating obese from normal-weight adolescents.

Cho K, Moon JS, Kang JH, Jang HB, Lee HJ, Park SI, Yu KS, Cho JY.

Pediatr Obes 2017,Jan;12(2):93-101.

Pharmacokinetic characteristics of fluticasone, salmeterol and tiotropium after concurrent inhalation

선우정, 이수진, 이승환, 이상원, 정진아, 손한길, 장인진

Translational and Clinical Pharmacology 2017,Jan;2017, vol.25, no.2, pp. 85-92 (8 pages)

Comparative pharmacokinetic and bioequivalence evaluation of two formulations of morniflumate 350-mg tablets in healthy male subjects

Heechan Lee, Sung-Vin Yim, Bo-Hyung Kim, SeungHwan Lee

International journal of clinical pharmacology and therapeutics. 2017,Jan;Int J Clin Pharmacol Ther. 2017 Jan;55(1):95-101