Pharmacometabolomics uncovers key metabolic changes in the first-in-human study of β-lapachone derivative

Yeonseo Jang, Jihyun Kang, Yufei Li, Woori Chae, Eunsol Yang, SeungHwan Lee, Joo-Youn Cho

Metabolomics 2025,Aug;2025 Aug 19;21(5):122. doi: 10.1007/s11306-025-02332-1.

A parallel reaction monitoring-mass spectrometric method for studying lipid biosynthesis in vitro using 13C16-palmitate as an isotope tracer

Kyeong-Seog Kim, Young Gyun Ko, Woo Seok Yang, Hye Young Kim, Joo-Youn Cho

Anal Chim Acta 2025,Jun;1354:344003. doi: 10.1016/j.aca.2025.344003. Epub 2025 Apr 1.

Integrated genomics and metabolomics to identify cause-specific biomarkers for chronic kidney disease in a Korean population

Min Woo Kang, Ji-Eun Kim, Jihyun Kang, Seonmi Kim, JooYong Park, Sohyun Bae, Yon Su Kim, Ji-Yeob Choi, Joo-Youn Cho, Seung Seok Han

Kidney Res Clin Pract 2025,Jun;2025 Jun 2. doi: 10.23876/j.krcp.24.135. Online ahead of print.

Integrating Personal Health Records to Improve Data Integrity in Trials With Decentralized Elements: A Pilot Study

Yoonjin Kim, Ki Young Huh, Kyung-Sang Yu

Clin Transl Sci 2025,Jun;2025 Jun;18(6):e70267. doi: 10.1111/cts.70267.

Introducing Korea metabolomics data repository (KMAP): bridging Korean metabolomics data to global data sharing infrastructure

Woori Chae, Joo-Youn Cho, Kyo Bin Kang; Metabolomics Data Curation Center (MDCC)

Metabolomics 2025,Jun;2025 Jun 22;21(4):86. doi: 10.1007/s11306-025-02285-5.

Association between the difference in creatinine-based and creatinine-cystatin C-based estimated glomerular filtration rates and vancomycin systemic exposure after ventricular assist device surgery

Jaegu Kang, Jisoo Song, SeungHwan Lee, Kyung-Sang Yu, Ki Young Huh

Transl Clin Pharmacol 2025,Jun;2025 Jun;33(2):80-89. doi: 10.12793/tcp.2025.33.e8. Epub 2025 Jun 24.

Pharmacokinetic comparison between the fixed-dose combination of rosuvastatin/ezetimibe 2.5/10 mg and the co-administration of individual formulations in healthy subjects

Dowon Lee, Sejung Hwang, Taewon Lee, Kyung-Sang Yu, SeungHwan Lee

Transl Clin Pharmacol 2025,Jun;2025 Jun;33(2):100-110. doi: 10.12793/tcp.2025.33.e6. Epub 2025 Jun 17.

Quantitation of methotrexate polyglutamates in red blood cells and application in patients with Crohn's disease

Hakmin Kim, Kyeong-Seog Kim, Sihyun Kim, Jihyun Kang, Hyun Chul Kim, Sejung Hwang, Jae-Yong Chung, Hyuk Yoon, Joo-Youn Cho

Transl Clin Pharmacol 2025,Jun;2025 Jun;33(2):66-79. doi: 10.12793/tcp.2025.33.e7. Epub 2025 Jun 23.

Quantitation of methotrexate polyglutamates in red blood cells and application in patients with Crohn's disease

Hakmin Kim, Kyeong-Seog Kim, Sihyun Kim, Jihyun Kang, Hyun Chul Kim, Sejung Hwang, Jae-Yong Chung, Hyuk Yoon, Joo-Youn Cho

Transl Clin Pharmacol 2025,Jun;2025 Jun;33(2):66-79. doi: 10.12793/tcp.2025.33.e7. Epub 2025 Jun 23.

Accurate Determination of Circulatory Lipids Using a Combination of HILIC-MRM and RPLC-PRM

Kyeong-Seog Kim, Jae-Seung Lee, Seung Seok Han, Joo-Youn Cho

Anal Chem 2025,May;doi: 10.1021/acs.analchem.4c06409. Online ahead of print.

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Topical Applications of Sodium Taurodeoxycholate, a Treatment for Atopic Dermatitis

Heejae Won, Inseung Jeon, Joo-Youn Cho, Seung-Yong Seong, Kyung-Sang Yu

Clinical and Translational Science 2025,May;18(5):e70242. doi: 10.1111/cts.70242.

Saliva-based lacosamide monitoring paves the way toward personalized epilepsy pharmacotherapy

Yoonhyuk Jang, Seon-Jae Ahn, Soyoung Lee, Yongmoo Kim, Han Sang Lee, Yoon-Kyung Lee, Yong Woo Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Joo-Youn Cho, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, In-Jin Jang, Sang Kun Lee

Sci Rep 2025,May;2025 May 31;15(1):19181. doi: 10.1038/s41598-025-04044-x.

Coadministration of Voriconazole and Rifabutin Can Increase the Risk of Adverse Drug Reactions in Patients with Multiple Infections

Yoonjin Kim, Sungyeun Bae, Ki Young Huh, Jong Sun Joo, Jikyo Lee, Sang Hoon Song, Kyung-Sang Yu, In-Jin Jang, Jaeseong Oh

Ther Drug Monit 2025,Apr;47(2):303-308. doi: 10.1097/FTD.0000000000001241. Epub 2024 Jul 16.

Modulating the PD-1-FABP5 axis in ILC2s to regulate adipose tissue metabolism in obesity

Jongho Ham, Jaemoon Koh, Jungeun Kim, Joo-Youn Cho, TaeSoo Kim, Doo Hyun Chung, Yong-Soo Bae, Hye Young Kim

Mol Ther 2025,Apr;33(4):1842-1859. doi: 10.1016/j.ymthe.2025.02.015. Epub 2025 Feb 12.

Evaluation of Safety, Pharmacokinetic, and Pharmacodynamic Characteristics of a Novel Dual mGluR5/5‑HT2AR Antagonist (VVZ‑2471) in a Randomized, Double‑Blind, First‑in‑Human Study

Sungyeun Bae, HyunJoon Lee, Inkyung Song, Jina Kim, Sang Rim Lee, Sunyoung Cho, Kyung-Sang Yu, Jae-Yong Chung

CNS Drugs 2025,Apr;doi: 10.1007/s40263-025-01181-9. Online ahead of print.

Comparative pharmacokinetics and bioequivalence of 145-mg fenofibrate formulations in healthy Korean participants

Sujong Lee, Byungwook Kim, SeungHwan Lee, Seung-Hyun Kang, Kyung-Sang Yu

Naunyn Schmiedebergs Arch Pharmacol 2025,Apr;doi: 10.1007/s00210-025-04086-y. Online ahead of print.

Short-term efficacy and safety of metformin in individuals with type 2 diabetes and mild hepatic impairment: A propensity score-matched real-world study

Seunghwan Baek, Jongseok Park, Jae-Yong Chung, Soo Heon Kwak, Seonghae Yoon

Diabetes Obes Metab 2025,Mar;32(3):150-158. doi: 10.12793/tcp.2024.32.e14. Epub 2024 Sep 25.

Exploration of Using an Open-Source Large Language Model for Analyzing Trial Information: A Case Study of Clinical Trials With Decentralized Elements

Ki Young Huh, Ildae Song, Yoonjin Kim, Jiyeon Park, Hyunwook Ryu, JaeEun Koh, Kyung-Sang Yu, Kyung Hwan Kim, SeungHwan Lee

Clin Transl Sci 2025,Mar;18(3):e70183. doi: 10.1111/cts.70183.

Pharmacokinetics of post-transplant cyclophosphamide and its associations with clinical outcomes in pediatric haploidentical hematopoietic stem cell transplantation

Kyung Taek Hong, Sungyeun Bae, Yoon Sunwoo, Juyeon Lee, Hyun Jin Park, Bo Kyung Kim, Jung Yoon Choi, Joo-Youn Cho, Kyung-Sang Yu, Jaeseong Oh, Hyoung Jin Kang

Biomark Res 2025,Mar;13(1):48. doi: 10.1186/s40364-025-00749-3.

Clinical development of oral semaglutide for the treatment of type 2 diabetes mellitus: focusing on early phase clinical trials

Heejae Won, Joo-Youn Cho, SeungHwan Lee

Transl Clin Pharmacol 2025,Mar;33(1):1-9. doi: 10.12793/tcp.2025.33.e3. Epub 2025 Mar 20.

Comparison of pharmacokinetics of a fixed-dose combination of atorvastatin/ezetimibe 5 mg/10 mg versus separate tablets in healthy subjects

Jisoo Song, Sungyeun Bae, Kyung-Sang Yu, SeungHwan Lee

Transl Clin Pharmacol 2025,Mar;33(1):40-49. doi: 10.12793/tcp.2025.33.e5. Epub 2025 Mar 24.

Population pharmacokinetic and pharmacodynamic model of evogliptin: Severe uremia increases the bioavailability of evogliptin

Byungwook Kim, Jung Eun Kim, Soyoung Lee, Jaeseong Oh, Joo-Youn Cho, In-Jin Jang, SeungHwan Lee, Jae-Yong Chung, Seonghae Yoon

CPT Pharmacometrics Syst Pharmacol 2025,Feb;doi: 10.1002/psp4.13263. Online ahead of print.

Pharmacokinetic comparison of a fixed-dose combination of telmisartan/rosuvastatin/ezetimibe/amlodipine 80/20/10/5 mg and a loose-dose combination of ezetimibe/rosuvastatin 10/20 mg and telmisartan/amlodipine 80/5 mg in healthy male subjects

Sooyoun Lee, Hyun Chul Kim, Kyung Tae Kim, Seung-Hyun Kang, SeungHwan Lee, Kyung-Sang Yu, Soyoung Lee

Naunyn Schmiedebergs Arch Pharmacol 2025,Feb;doi: 10.1007/s00210-025-03863-z. Online ahead of print.

Phase 1 studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 690517 (vicadrostat), a novel aldosterone synthase inhibitor, in healthy male volunteers

Friedrich Schulze, Jennifer Schaible, Markus Goettel, Yuko Tanaka, Kathrin Hohl, Armin Schultz, In-Jin Jang

Naunyn Schmiedebergs Arch Pharmacol 2025,Feb;doi: 10.1007/s00210-025-03838-0. Online ahead of print.

Clustering-Based Identification of BMI-Associated Metabolites with Mechanistic Insights from Network Analysis in Korean Men

JooYong Park, Jihyun Kang, Ji-Yeoun Lee, Daehee Kang, Joo-Youn Cho, Ji-Yeob Choi

Metabolites 2025,Feb;15(2):88. doi: 10.3390/metabo15020088.

Comparing haploidentical transplantation with post-transplantation cyclophosphamide and umbilical cord blood transplantation using targeted busulfan in children and adolescents with hematologic malignancies

Kyung Taek Hong, Bo Kyung Kim, Hong Yul An, Jung Yoon Choi, Sang Hoon Song, Kyung-Sang Yu, In-Jin Jang, Hyoung Jin Kang

Blood Res 2025,Jan;60(1):7. doi: 10.1007/s44313-025-00057-7.

Comparing the efficacy of different proton pump inhibitor dosing regimens for the treatment of gastroesophageal reflux disease: a systematic review and meta-analysis

Tyra Nguyen, Katherine Barnhill, Alex Zhornitskiy, Kyung Sang Yu, Garth Fuller, Katherine Makaroff, Brennan M R Spiegel, Gillian Gresham, Christopher V Almario

Dis Esophagus 2025,Jan;38(1):doae109. doi: 10.1093/dote/doae109.