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01

Evaluation of drug prescribing patterns and therapeutic drug monitoring practice using electronic medical records

Sangmi Lee, Seonghae Yoon, In-Jin Jang

Scientific reports. 2022,Dec;9;12(1):21377. doi: 10.1038/s41598-022-25794-y.
02

Pharmacokinetic evaluation of radiolabeled intraocular anti-CLEC14a antibody in preclinical animal species and application in humans

Sohyun Park, Youn Woo Lee, Jaeseong Oh, Su Jin Kim, Sukmook Lee, Ho-Young Lee

Clinical and translational science. 2022,Dec;15(12):2938-2946. doi: 10.1111/cts.13412. Epub 2022 Sep 27.
03

A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions

Sojeong Kim, Sang Won Lee, June-Young Koh, Donghoon Choi, Minkyu Heo, Jae-Yong Chung, Byung Ha Lee, Se Hwan Yang, Young Chul Sung, Howard Lee, Eui-Cheol Shin, Su-Hyung Park

Blood Adv 2022,Dec;6(23):6093-6107. doi: 10.1182/bloodadvances.2021006591.
04

Safety, tolerability, pharmacokinetic, and pharmacodynamic characteristics of vutiglabridin: A first-in-class, first-in-human study

Joo Young Na, Deok Yong Yoon, Hyounggyoon Yoo, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Sang-Ku Yoo, Youngah Kim, Jaeseong Oh

Clinical and translational science. 2022,Nov;;15(11):2744-2757. doi: 10.1111/cts.13401. Epub 2022 Oct 10.
05

Effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of lacosamide in Korean patients with epilepsy

Seon-Jae Ahn, Jaeseong Oh, Do-Yong Kim, Hyoshin Son, Sungeun Hwang, Hye-Rim Shin, Eun Young Kim, Han Sang Lee, Woo-Jin Lee, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, Sang Kun Lee

EPILEPSIA 2022,Nov;63(11):2958-2969. doi: 10.1111/epi.17399. Epub 2022 Aug 30.
06

Efficacy and safety of a new ranibizumab biosimilar CKD-701 using a pro re nata treatment regimen in neovascular age-related macular degeneration: A phase 3 randomized clinical trial

Chang Ki Yoon, Jaeryung Oh, Kunho Bae, Un Chul Park, Kyung-Sang Yu, Hyeong Gon Yu

PloS one. 2022,Nov;14;17(11):e0275611. doi: 10.1371/journal.pone.0275611. eCollection 2022.
07

A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population

Jeongeun Lee, Jean Lee, Sungwon Jeon, Jeongha Lee, Insu Jang, Jin Ok Yang, Soojin Park, Byungwook Lee, Jinwook Choi, Byung-Ok Choi, Heon Yung Gee, Jaeseong Oh, In-Jin Jang, Sanghyuk Lee, Daehyun Baek, Youngil Koh, Sung-Soo Yoon, Young-Joon Kim, Jong

Experimental & molecular medicine. 2022,Nov;54(11):1862-1871. doi: 10.1038/s12276-022-00871-4. Epub 2022 Nov 2.
08

Identification of Serum Metabolites for Predicting Chronic Kidney Disease Progression according to Chronic Kidney Disease Cause

Eunjeong Kang, Yufei L, Bora Kim, Ki Young Huh, Miyeun Han, Jung-Hyuck Ahn 5, Hye Youn Sung 5, Yong Seek Park 6, Seung Eun Lee, Sangjun Lee, Sue K Park, Joo-Youn Cho, Kook-Hwan Oh

Metabolites. 2022,Nov;16;12(11):1125. doi: 10.3390/metabo12111125.
09

Safety, Tolerability, and Serum/Tear Pharmacokinetics of Human Recombinant Epidermal Growth Factor Eyedrops in Healthy Subjects

Hyounggyoon Yoo, Seonghae Yoon, In-Jin Jang, Kyung-Sang Yu, Joon Young Hyon , Jungi Hwang, Inyoung Hwang, Jung Sunwoo, Jae-Yong Chung

Pharmaceuticals 2022,Oct;24;15(11):1312. doi: 10.3390/ph15111312.
10

Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue

Jihyun Kang, Jeong Yeon Kim, Youjin Jung, Seon Uk Kim, Eun Young Lee, Joo-Youn Cho

Metabolites. 2022,Oct;21;12(10):1004. doi: 10.3390/metabo12101004.
11

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim

Nat Commun 2022,Oct;13(1):6080. doi: 10.1038/s41467-022-33749-0.
12

Spouse bereavement and brain pathologies: A propensity score matching study

Jee Wook Kim, Min Soo Byun, Jun Ho Lee, Dahyun Yi, Min Jung Kim, Gijung Jung, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee; KBASE Research Group

Psychiatry Clin Neurosci 2022,Oct;76(10):490-504. doi: 10.1111/pcn.13439. Epub 2022 Jul 18. KBASE Research Group(조)
13

Dose-dependent glucosuria of DWP16001, a novel selective sodium-glucose cotransporter-2 inhibitor, in healthy subjects

Jun Gi Hwang, SeungHwan Lee, Wan Huh, Jumi Han, Jaeseong Oh, In-Jin Jang, Kyung-Sang Yu

British journal of clinical pharmacology 2022,Sep;88(9):4100-4110. doi: 10.1111/bcp.15348. Epub 2022 Apr 22.
14

The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects

Sejung Hwang, Soyoung Lee, Eunwoo Kim, Inyoung Hwang, Joo-Youn Cho , Jae-Yong Chung, In-Jin Jang, Jaeseong Oh

Clinical and translational science. 2022,Sep;15(9):2116-2126. doi: 10.1111/cts.13344. Epub 2022 Jun 21.
15

A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808

Tae Kyu Chung, Hyun A Lee, Kyeong-Ryoon Lee, Seong Bok Jang, Kyung-Sang Yu, Howard Lee

CPT: pharmacometrics & systems pharmacology. 2022,Sep;11(9):1223-1233. doi: 10.1002/psp4.12839. Epub 2022 Jul 9.
16

Considerations for clinical evaluation of the effects of bariatric surgery on the pharmacokinetics of orally administered drugs

Sungyeun Bae, JungJin Oh, Ildae Song, Kyung-Sang Yu, SeungHwan Lee

Translational and clinical pharmacology. 2022,Sep;30(3):145-154. doi: 10.12793/tcp.2022.30.e15. Epub 2022 Sep 26.
17

Association of Metabolic Signatures with Nonalcoholic Fatty Liver Disease in Pediatric Population

Woori Chae, Kyung Jae Lee, Ki Young Huh, Jin Soo Moon, Jae Sung Ko, Joo-Youn Cho

Metabolites . 2022,Sep;19;12(9):881. doi: 10.3390/metabo12090881.
18

Factors affecting the changes in antihypertensive medications in patients with hypertension

Tae Kyu Chung, Yoomin Jeon, YeSol Hong, Suyeon Hong, Jun Sik Moon, Howard Lee

Front Cardiovasc Med 2022,Sep;9:999548. doi: 10.3389/fcvm.2022.999548. eCollection 2022.
19

How to boost and accelerate new drug development in Korea: business ecosystem perspectives

Yoona Choi, Howard Lee

Transl Clin Pharmacol 2022,Sep;30(3):129-135. doi: 10.12793/tcp.2022.30.e17. Epub 2022 Sep 27.
20

Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

Inyoung Hwang, Sang Won Lee, Jaeseong Oh, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Front Pharmacol 2022,Aug;13:930615. doi: 10.3389/fphar.2022.930615. eCollection 2022.
21

Night-time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole

Eunsol Yang, Seokuee Kim, Bongtae Kim, Boram Kim, Yechan Kim, Sung Sup Park, Geun Seog Song, Kyung-Sang Yu, In-Jin Jang, Seung Hwan Lee

British journal of clinical pharmacology. 2022,Jul;;88(7):3288-3296. doi: 10.1111/bcp.15268. Epub 2022 Feb 23.
22

Clinical Evaluation of Digital Therapeutics: Present and Future

Ki Young Huh, Jaeseong Oh, SeungHwan Lee, Kyung-Sang Yu

Healthcare informatics research. 2022,Jul;Jul;28(3):188-197. doi: 10.4258/hir.2022.28.3.188. Epub 2022 Jul 31.
23

Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information

Ha Young Jang, Jihyeon Song, Jae Hyun Kim, Howard Lee, In-Wha Kim, Bongki Moon, Jung Mi Oh

NPJ Digit Med 2022,Jul;5(1):88. doi: 10.1038/s41746-022-00639-0.
24

Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination

Hyun Chul Kim, Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Jang Hee Hong, JaeWoo Kim

Translational and clinical pharmacology. 2022,Jun;Jun;30(2):112-119. doi: 10.12793/tcp.2022.30.e12. Epub 2022 Jun 27.
25

Key Considerations for Phase 2 or 3 Clinical Study Design of Anti-Inflammatory Agent for COVID-19 Treatment

Yewon Park, Joo Young Na, Joo-Youn Cho, Jaeseong Oh, Su-Jin Rhee

Frontiers in pharmacology. 2022,Jun;Jun 2;13:842836. doi: 10.3389/fphar.2022.842836. eCollection 2022.
26

An Improved Method to Quantify Short-Chain Fatty Acids in Biological Samples Using Gas Chromatography-Mass Spectrometry

Kyeong-Seog Kim, Yujin Lee, Woori Chae, Joo-Youn Cho

Metabolites 2022,Jun;Jun 7;12(6):525. doi: 10.3390/metabo12060525.
27

Therapeutic drug monitoring on the use of transplacental digoxin in fetal tachyarrhythmia: a case report

Sae Im Jeong, Heejae Won, Ildae Song, Jaeseong Oh

Translational and clinical pharmacology. 2022,Jun;Jun;30(2):83-86. doi: 10.12793/tcp.2022.30.e11. Epub 2022 Jun 22.
28

Population Pharmacokinetic Model of AST-001, L-Isomer of Serine, Combining Endogenous Production and Exogenous Administration in Healthy Subjects

Soyoung Lee, Su-Kyeong Hwang, Hee-Sook Nam, Jung-Sook Cho, Jae-Yong Chung

Frontiers in pharmacology. 2022,Jun;24;13:891227. doi: 10.3389/fphar.2022.891227. eCollection 2022.
29

Lessons from a multicenter clinical trial with an approved wearable electrocardiogram: issues and practical considerations

Ki Young Huh, Sae Im Jeong, Hyounggyoon Yoo, Meihua Piao, Hyeongju Ryu, Heejin Kim, Young-Ran Yoon, Sook Jin Seong, SeungHwan Lee, Kyung Hwan Kim

Transl Clin Pharmacol 2022,Jun;30(2):87-98. doi: 10.12793/tcp.2022.30.e7. Epub 2022 May 24.
30

Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase

Jihyun Kang, Andrew HyoungJin Kim, Inseung Jeon, Jaeseong Oh, In-Jin Jang, SeungHwan Lee, Joo-Youn Cho

Clinical and translational science. 2022,May; May;15(5):1104-1111. doi: 10.1111/cts.13203. Epub 2021 Dec 4.
31

Comparative Pharmacokinetics Between a Fixed-Dose Combination of Pitavastatin/Valsartan 4/160 mg and the Corresponding Individual Components Through a Partial Replicated Crossover Design in Healthy Male Subjects

Joo Young Na, Eunsol Yang, Jae-Hoon Kim, In Sun Kwon, Eun-Heui Jin, Kyung-Sang Yu, Jinsook Kim, SeungHwan Lee, Jang Hee Hong

Clinical pharmacology in drug development. 2022,May;;11(5):615-622. doi: 10.1002/cpdd.1054. Epub 2022 Jan 8.
32

Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects

Joo Young Na, Ki Young Huh, Kyung-Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You , Jae-Yong Chung

Clinical and translational science. 2022,May;15(5):1123-1130. doi: 10.1111/cts.13226. Epub 2022 Feb 8.
33

Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension

Su-Jin Rhee, Seung Han Shin, Jaeseong Oh, Young Hwa Jung, Chang Won Choi, Han-Suk Kim, Kyung-Sang Yu

Scientific Reports 2022,May;May 5;12(1):7393. doi: 10.1038/s41598-022-11038-6.
34

Evaluation of a blockchain-based dynamic consent platform (METORY) in a decentralized and multicenter clinical trial using virtual drugs

Ki Young Huh, Seol Ju Moon, Sang-Un Jeong, Min-Ji Kim, Wooseok Yang, Myeonggyu Jeong, Min-Gul Kim, SeungHwan Lee

Clin Transl Sci 2022,May;15(5):1257-1268. doi: 10.1111/cts.13246. Epub 2022 Feb 17.
35

METORY: Development of a Demand-Driven Blockchain-Based Dynamic Consent Platform Tailored for Clinical Trials

Ki Young Huh, Sang-Un Jeong, Seol Ju Moon, Min-Ji Kim, Wooseok Yang, Myeonggyu Jeong, Ildae Song, Yong-Geun Kwak, SeungHwan Lee, Min-Gul Kim

Front Med (Lausanne) 2022,May;9:837197. doi: 10.3389/fmed.2022.837197. eCollection 2022.
36

Single-dose of LC51-0255, a selective S1P 1 receptor modulator, showed dose-dependent and reversible reduction of absolute lymphocyte count in humans

Sang Won Lee, Inyoung Hwang, Jaeseong Oh, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Clinical and translational science 2022,Apr;Apr;15(4):1074-1083. doi: 10.1111/cts.13227. Epub 2022 Jan 23.
37

A double-blind, placebo-controlled, single-ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM15136, a novel long-acting glucagon analogue, in healthy subjects

Ki Young Huh, Jun Gi Hwang, Wonjung Shin, Seungjae Baek, JaeDuk Choi, Nora Lee, Young Min Cho, Howard Lee

Diabetes, obesity & metabolism. 2022,Mar;4(3):411-420. doi: 10.1111/dom.14590. Epub 2021 Nov 24.
38

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

Mary Beth Wire, Soo Youn Jun, In-Jin Jang, Seung-Hwan Lee, Jun Gi Hwang, David B Huang

Antimicrobial agents and chemotherapy 2022,Mar;66(3):e0184221. doi: 10.1128/AAC.01842-21. Epub 2022 Jan 10.
39

A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects

Yoomin Jeon, Nora Lee, Seungjae Baek, JaeDuk Choi, Stanford Jhee, Howard Lee

Drugs in R&D. 2022,Mar;22(1):71-87. doi: 10.1007/s40268-021-00379-8. Epub 2022 Jan 6.
40

Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects

Yewon Park, WonTae Jung, Eunsol Yang, Kyu-Yeol Nam, Woo-Ri Bong, Jaehee Kim, Kyu Yeon Kim, SeungHwan Lee, Joo-Youn Cho, Jang-Hee Hong, JaeWoo Kim

Translational and clinical pharmacology. 2022,Mar; Mar;30(1):49-56. doi: 10.12793/tcp.2022.30.e3. Epub 2022 Mar 7.
41

Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series

Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo-Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung-Don Oh, Nam Joong Kim

Clin Transl Sci 2022,Mar;15(3):732-740. doi: 10.1111/cts.13194. Epub 2021 Nov 20.
42

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non-Japanese

Eunsol Yang, Jung Sunwoo, Ki Young Huh, Yu Kyong Kim, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Clinical and translational science. 2022,Feb;15(2):490-500. doi: 10.1111/cts.13167. Epub 2021 Oct 20.
43

A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults

Jihyun Jung, Ki Young Huh, Xuanyou Jin, Ahnul Ha, Ki Ho Park, Jun Sang Park, Eunjung Kim, Jaehwi Lee, In-Jin Jang, Howard Lee

Clinical and translational science. 2022,Feb; Feb;15(2):343-352. doi: 10.1111/cts.13150. Epub 2021 Sep 15.
44

Pharmacokinetics and safety of a novel influenza treatment (baloxavir marboxil) in Korean subjects compared with Japanese subjects

Yun Kim, Sangwon Lee, Yohan Kim, In-Jin Jang, SeungHwan Lee

Clinical and translational science. 2022,Feb; Feb;15(2):422-432. doi: 10.1111/cts.13160. Epub 2021 Oct 19.
45

An annotated corpus from biomedical articles to construct a drug-food interaction database

Siun Kim, Yoona Choi, Jung-Hyun Won, Jung Mi Oh, Howard Lee

Journal of biomedical informatics. 2022,Feb;126:103985. doi: 10.1016/j.jbi.2022.103985. Epub 2022 Jan 7.
46

Evaluation of safety and pharmacokinetics of bismuth-containing quadruple therapy with either vonoprazan or lansoprazole for Helicobacter pylori eradication

Ki Young Huh, Hyewon Chung, Yu Kyong Kim, Seung Hwan Lee, Siddharth Bhatia, Yohei Takanami, Ryou Nakaya, Kyung-Sang Yu

British journal of clinical pharmacology. 2022,Jan;88(1):138-144. doi: 10.1111/bcp.14934. Epub 2021 Jun 26.
47

Pharmacokinetic and Pharmacodynamic Characteristics of Tripegfilgrastim, a Pegylated G-CSF, in Pediatric Patients with Solid Tumors

Soyoung Lee, Kyung Taek Hong, Seol Ju Moon, Jung Yoon Choi, Che Ry Hong, Hee Young Shin, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jaeseong Oh, Hyoung Jin Kang

Clinical pharmacology and therapeutics. 2022,Jan;2022 Jan;111(1):293-301. doi: 10.1002/cpt.2433.
48

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

Bonah Kim, Hee Young Kim, Bo Ruem Yoon, Jina Yeo, Ji In Jung, Kyung-Sang Yu, Hyeon Chang Kim, Su-Jin Yoo, Jin Kyun Park, Seong Wook Kang, Won-Woo Lee

Science signaling. 2022,Jan;11;15(716):eabi7400. doi: 10.1126/scisignal.abi7400. Epub 2022 Jan 11.
49

Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components

Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung

Clinical pharmacology in drug development. 2022,Jan;11(1):91-99. doi: 10.1002/cpdd.963. Epub 2021 Jun 22.
50

Clinical Response and Hospital Costs of Therapeutic Drug Monitoring for Vancomycin in Elderly Patients

Yun Kim, Soohyun Kim, Jinsook Park, Howard Lee

J Pers Med 2022,Jan;12(2):163. doi: 10.3390/jpm12020163.

There are total 50 results.

Department of Clinical Pharmacology and Therapeutics of Seoul National University Hospital (SNUCPT) Room 502-3, Seoul National University College of Medicine Convergence Hall Tel : 02-740-8957FAX : 02-740-8963

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