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01

Effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of lacosamide in Korean patients with epilepsy

Seon-Jae Ahn, Jaeseong Oh, Do-Yong Kim, Hyoshin Son, Sungeun Hwang, Hye-Rim Shin, Eun Young Kim, Han Sang Lee, Woo-Jin Lee, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, Sang Kun Lee

EPILEPSIA 2022,Aug; Aug 21. doi: 10.1111/epi.17399. Online ahead of print.
02

Clinical Evaluation of Digital Therapeutics: Present and Future

Ki Young Huh, Jaeseong Oh, SeungHwan Lee, Kyung-Sang Yu

Healthcare informatics research. 2022,Jul;Jul;28(3):188-197. doi: 10.4258/hir.2022.28.3.188. Epub 2022 Jul 31.
03

The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects

Sejung Hwang, Soyoung Lee, Eunwoo Kim, Inyoung Hwang, Joo-Youn Cho , Jae-Yong Chung, In-Jin Jang, Jaeseong Oh

Clinical and translational science. 2022,Jun; Jun 21. doi: 10.1111/cts.13344. Online ahead of print.
04

A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808

Tae Kyu Chung, Hyun A Lee, Kyeong-Ryoon Lee, Seong Bok Jang, Kyung-Sang Yu, Howard Lee

CPT: pharmacometrics & systems pharmacology. 2022,Jun;Jun 24. doi: 10.1002/psp4.12839. Online ahead of print.
05

Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination

Hyun Chul Kim, Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Jang Hee Hong, JaeWoo Kim

Translational and clinical pharmacology. 2022,Jun;Jun;30(2):112-119. doi: 10.12793/tcp.2022.30.e12. Epub 2022 Jun 27.
06

Key Considerations for Phase 2 or 3 Clinical Study Design of Anti-Inflammatory Agent for COVID-19 Treatment

Yewon Park, Joo Young Na, Joo-Youn Cho, Jaeseong Oh, Su-Jin Rhee

Frontiers in pharmacology. 2022,Jun;Jun 2;13:842836. doi: 10.3389/fphar.2022.842836. eCollection 2022.
07

An Improved Method to Quantify Short-Chain Fatty Acids in Biological Samples Using Gas Chromatography-Mass Spectrometry

Kyeong-Seog Kim, Yujin Lee, Woori Chae, Joo-Youn Cho

Metabolites 2022,Jun;Jun 7;12(6):525. doi: 10.3390/metabo12060525.
08

Therapeutic drug monitoring on the use of transplacental digoxin in fetal tachyarrhythmia: a case report

Sae Im Jeong, Heejae Won, Ildae Song, Jaeseong Oh

Translational and clinical pharmacology. 2022,Jun;Jun;30(2):83-86. doi: 10.12793/tcp.2022.30.e11. Epub 2022 Jun 22.
09

Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase

Jihyun Kang, Andrew HyoungJin Kim, Inseung Jeon, Jaeseong Oh, In-Jin Jang, SeungHwan Lee, Joo-Youn Cho

Clinical and translational science. 2022,May; May;15(5):1104-1111. doi: 10.1111/cts.13203. Epub 2021 Dec 4.
10

Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension

Su-Jin Rhee, Seung Han Shin, Jaeseong Oh, Young Hwa Jung, Chang Won Choi, Han-Suk Kim, Kyung-Sang Yu

Scientific Reports 2022,May;May 5;12(1):7393. doi: 10.1038/s41598-022-11038-6.
11

Dose-dependent glucosuria of DWP16001, a novel selective sodium-glucose cotransporter-2 inhibitor, in healthy subjects

Jun Gi Hwang, SeungHwan Lee, Wan Huh, Jumi Han, Jaeseong Oh, In-Jin Jang, Kyung-Sang Yu

British journal of clinical pharmacology 2022,Apr;Apr 8. doi: 10.1111/bcp.15348. Online ahead of print.
12

Single-dose of LC51-0255, a selective S1P 1 receptor modulator, showed dose-dependent and reversible reduction of absolute lymphocyte count in humans

Sang Won Lee, Inyoung Hwang, Jaeseong Oh, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Clinical and translational science 2022,Apr;Apr;15(4):1074-1083. doi: 10.1111/cts.13227. Epub 2022 Jan 23.
13

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

Mary Beth Wire, Soo Youn Jun, In-Jin Jang, Seung-Hwan Lee, Jun Gi Hwang, David B Huang

Antimicrobial agents and chemotherapy 2022,Mar;2022 Mar 15;66(3):e0184221. doi: 10.1128/AAC.01842-21. Epub 2022 Jan 10.
14

Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects

Yewon Park, WonTae Jung, Eunsol Yang, Kyu-Yeol Nam, Woo-Ri Bong, Jaehee Kim, Kyu Yeon Kim, SeungHwan Lee, Joo-Youn Cho, Jang-Hee Hong, JaeWoo Kim

Translational and clinical pharmacology. 2022,Mar; Mar;30(1):49-56. doi: 10.12793/tcp.2022.30.e3. Epub 2022 Mar 7.
15

Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series

Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo-Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung-Don Oh, Nam Joong Kim

Translational and clinical pharmacology. 2022,Mar;Mar;15(3):732-740. doi: 10.1111/cts.13194. Epub 2021 Nov 20.
16

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non-Japanese

Eunsol Yang, Jung Sunwoo, Ki Young Huh, Yu Kyong Kim, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Clinical and translational science. 2022,Feb;15(2):490-500. doi: 10.1111/cts.13167. Epub 2021 Oct 20.
17

A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults

Jihyun Jung, Ki Young Huh, Xuanyou Jin, Ahnul Ha, Ki Ho Park, Jun Sang Park, Eunjung Kim, Jaehwi Lee, In-Jin Jang, Howard Lee

Clinical and translational science. 2022,Feb; Feb;15(2):343-352. doi: 10.1111/cts.13150. Epub 2021 Sep 15.
18

Pharmacokinetics and safety of a novel influenza treatment (baloxavir marboxil) in Korean subjects compared with Japanese subjects

Yun Kim, Sangwon Lee, Yohan Kim, In-Jin Jang, SeungHwan Lee

Clinical and translational science. 2022,Feb; Feb;15(2):422-432. doi: 10.1111/cts.13160. Epub 2021 Oct 19.
19

Night-time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole

Eunsol Yang, Seokuee Kim, Bongtae Kim, Boram Kim, Yechan Kim, Sung Sup Park, Geun Seog Song, Kyung-Sang Yu, In-Jin Jang, Seung Hwan Lee

British journal of clinical pharmacology. 2022,Feb;10. doi: 10.1111/bcp.15268. Online ahead of print.
20

Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects

Joo Young Na, Ki Young Huh, Kyung-Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You , Jae-Yong Chung

Clinical and translational science. 2022,Feb; 8. doi: 10.1111/cts.13226. Online ahead of print.
21

An annotated corpus from biomedical articles to construct a drug-food interaction database

Siun Kim, Yoona Choi, Jung-Hyun Won, Jung Mi Oh, Howard Lee

Journal of biomedical informatics. 2022,Feb;126:103985. doi: 10.1016/j.jbi.2022.103985. Epub 2022 Jan 7.
22

Evaluation of safety and pharmacokinetics of bismuth-containing quadruple therapy with either vonoprazan or lansoprazole for Helicobacter pylori eradication

Ki Young Huh, Hyewon Chung, Yu Kyong Kim, Seung Hwan Lee, Siddharth Bhatia, Yohei Takanami, Ryou Nakaya, Kyung-Sang Yu

British journal of clinical pharmacology. 2022,Jan;88(1):138-144. doi: 10.1111/bcp.14934. Epub 2021 Jun 26.
23

Pharmacokinetic and Pharmacodynamic Characteristics of Tripegfilgrastim, a Pegylated G-CSF, in Pediatric Patients with Solid Tumors

Soyoung Lee, Kyung Taek Hong, Seol Ju Moon, Jung Yoon Choi, Che Ry Hong, Hee Young Shin, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jaeseong Oh, Hyoung Jin Kang

Clinical pharmacology and therapeutics. 2022,Jan;2022 Jan;111(1):293-301. doi: 10.1002/cpt.2433.
24

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

Bonah Kim, Hee Young Kim, Bo Ruem Yoon, Jina Yeo, Ji In Jung, Kyung-Sang Yu 5, Hyeon Chang Kim, Su-Jin Yoo, Jin Kyun Park, Seong Wook Kang, Won-Woo Lee

Science signaling. 2022,Jan;11;15(716):eabi7400. doi: 10.1126/scisignal.abi7400. Epub 2022 Jan 11.
25

Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components

Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung

Clinical pharmacology in drug development. 2022,Jan;11(1):91-99. doi: 10.1002/cpdd.963. Epub 2021 Jun 22.
26

Comparative Pharmacokinetics Between a Fixed-Dose Combination of Pitavastatin/Valsartan 4/160 mg and the Corresponding Individual Components Through a Partial Replicated Crossover Design in Healthy Male Subjects

Joo Young Na, Eunsol Yang, Jae-Hoon Kim, In Sun Kwon, Eun-Heui Jin, Kyung-Sang Yu, Jinsook Kim, SeungHwan Lee, Jang Hee Hong

Clinical pharmacology in drug development. 2022,Jan;8. doi: 10.1002/cpdd.1054. Online ahead of print.
27

A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects

Yoomin Jeon, Nora Lee, Seungjae Baek, JaeDuk Choi, Stanford Jhee, Howard Lee

Drugs in R&D. 2022,Jan;6. doi: 10.1007/s40268-021-00379-8. Online ahead of print.
28

Influence of CYP2C19 Polymorphisms on the Pharmacokinetics of Omeprazole in Elderly Subjects

Joo Young Na, Inseung Jeon, Jangsoo Yoon, Yewon Choi, Seo Hyun Yoon, Kyung-Sang Yu, Jae-Yong Chung

Clinical pharmacology in drug development. 2021,Dec;10(12):1469-1477. doi: 10.1002/cpdd.966.
29

Comparative Pharmacokinetics/Pharmacodynamics of Fixed-Dose Combination of Esomeprazole and Calcium Carbonate (AD-206) to the Conventional Esomeprazole

Sungyeun Bae, Jihoon Kwon, Si-Beum Lee, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug design, development and therapy. 2021,Dec;Dec 21;15:5099-5108.
30

The necessary conduct: Exploratory multiregional clinical trials in East Asia

Inseung Jeon, Yu Kyong Kim, Ildae Song , Deok Yong Yoon, Ki Young Huh, Xuanyou Jin, Kyung-Sang Yu, SeungHwan Lee, Yuji Kumagai, In-Jin Jang

Clinical and translational science. 2021,Nov;14(6):2399-2407. doi: 10.1111/cts.13106.
31

Pharmacokinetics of Ginsenoside Compound K From a Compound K Fermentation Product, CK-30, and From Red Ginseng Extract in Healthy Korean Subjects

Mu Seong Ban, Yun Kim, Sunyoung Lee, ByongYeul Han, Kyung-Sang Yu, In-Jin Jang, Hong Keun Chung, SeungHwan Lee

Clinical pharmacology in drug development. 2021,Nov;2021 Nov;10(11):1358-1364. doi: 10.1002/cpdd.949.
32

Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series

Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo-Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung-Don Oh, Nam Joong Kim

Clinical and translational science. 2021,Nov;10;10.1111/cts.13194. doi: 10.1111/cts.13194.
33

A double-blind, placebo-controlled, single-ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM15136, a novel long-acting glucagon analogue, in healthy subjects

Ki Young Huh, Jun Gi Hwang, Wonjung Shin, Seungjae Baek, JaeDuk Choi, Nora Lee, Young Min Cho, Howard Lee

Diabetes, obesity & metabolism. 2021,Nov;2. doi: 10.1111/dom.14590. Online ahead of print.
34

Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects

Hyewon Chung, Seo Hyun Yoon, Joo-Youn Cho, Hee Kyung Yeo, Dongseong Shin, Ji-Young Park

International journal of clinical pharmacology and therapeutics. 2021,Oct;59(10):684-690. doi: 10.5414/CP204058.
35

Unraveling the Genomic Architecture of the CYP3A Locus and ADME Genes for Personalized Tacrolimus Dosing

Jihoon G Yoon, Seung Hwan Song, Sungkyoung Choi, Jaeseong Oh, In-Jin Jang, Young Jin Kim, Sanghoon Moon, Bong-Jo Kim, Yuri Cho, Hyo Kee Kim, Sangil Min, Jongwon Ha, Ho Sik Shin 10, Chul Woo Yang, Hye Eun Yoon, Jaeseok Yang, Min Goo Lee, Jae Berm Park, My

Transplantation. 2021,Oct;1;105(10):2213-2225. doi: 10.1097/TP.0000000000003660.
36

Effects of vancomycin-induced gut microbiome alteration on the pharmacodynamics of metformin in healthy male subjects

Eunwoo Kim, Andrew Hyoungjin Kim, Yujin Lee, Sang Chun Ji, Joo-Youn Cho, Kyung-Sang Yu, Jae-Yong Chung

Clinical and translational science 2021,Sep;14(5):1955-1966. doi: 10.1111/cts.13051.
37

Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform

Byungwook Kim, Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu, Joo-Youn Cho, Jaeseong Oh

Translational and clinical pharmacology. 2021,Sep;29(3):135-149. doi: 10.12793/tcp.2021.29.e14.
38

Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem

Seonghae Yoon, Seongmee Jeong, Eben Jung, Ki Soon Kim, Inseung Jeon, Yujin Lee, Joo-Youn Cho, Woo-Yong Oh, Jae-Yong Chung

Scientific reports. 2021,Sep;27;11(1):19150. doi: 10.1038/s41598-021-98689-z.
39

Prediction of Drug-Drug Interaction Potential of Tegoprazan Using Physiologically Based Pharmacokinetic Modeling and Simulation

Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Myeongjoong Kim, Heechan Lee, Seokuee Kim, Bongtae Kim, Geun Seog Song, Su-Jin Rhee

Pharmaceutics. 2021,Sep;16;13(9):1489. doi: 10.3390/pharmaceutics13091489.
40

Relationship among genetic polymorphism of SLCO1B1, rifampicin exposure and clinical outcomes in patients with active pulmonary tuberculosis

Eun Sun Kim, Byoung Soo Kwon, Jong Sun Park, Jae-Yong Chung, Soo Hyun Seo, Kyoung Un Park, Junghan Song, Seonghae Yoon, Jae Ho Lee

British journal of clinical pharmacology. 2021,Sep;87(9):3492-3500. doi: 10.1111/bcp.14758.
41

Tissue pharmacokinetics of DHP107, a novel lipid-based oral formulation of paclitaxel, in mice and patients by positron emission tomography

Byung Seok Moon, Hyun Soo Park, Jung Sunwoo, In-Hyun Lee, Anhye Kim, Seol Ju Moon, Heechan Lee, Min Hee Son, Su Bin Kim, Sun Mi Park, Sang-Keun Woo, Jun-Hee Jang, Bom Sahn Kim, Jee Hyun Kim, Sang Eun Kim, Howard Lee

Clinical and translational science. 2021,Sep;14(5):1747-1755. doi: 10.1111/cts.13003.
42

Changes in the gut microbiome influence the hypoglycemic effect of metformin through the altered metabolism of branched-chain and nonessential amino acids

Yujin Lee, Andrew HyoungJin Kim, Eunwoo Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Jae-Yong Chung, Joo-Youn Cho

Diabetes research and clinical practice. 2021,Aug;178:108985. doi: 10.1016/j.diabres.2021.108985.
43

Urine 5-Eicosatetraenoic Acids as Diagnostic Markers for Obstructive Sleep Apnea

Hyun-Woo Shin, Kumsun Cho, Chae-Seo Rhee, Il-Hee Hong, Seok Hyun Cho, Sung Wan Kim, Jiyoung Kim, Daeho So, Joo-Youn Cho, Jong-Wan Park

Antioxidants. 2021,Aug;3;10(8):1242. doi: 10.3390/antiox10081242.
44

Safety, tolerability of ES16001, a novel varicella zoster virus reactivation inhibitor, in healthy adults

Jeon Hwang-Bo, Byungwook Kim, Dae Won Park, Yeong-Geun Le, Jeong Eun Kwon, Jae-Yong Chung, Se Chan Kang

European journal of medical research. 2021,Aug;12;26(1):92. doi: 10.1186/s40001-021-00565-z.
45

A population pharmacokinetic-pharmacodynamic model of YH12852, a highly selective 5-hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation

Siun Kim, Hyun A Lee, Seong Bok Jang, Howard Lee

CPT: pharmacometrics & systems pharmacology. 2021,Aug;10(8):902-913. doi: 10.1002/psp4.12664.
46

Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects

Sejung Hwang, Dae Young Lee, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug design, development and therapy 2021,Jun;1;15:2375-2384. doi: 10.2147/DDDT.S309763. eCollection 2021.
47

Home-based virtual reality for chronic pain: protocol for an NIH-supported randomised-controlled trial

Brandon Birckhead, Sam Eberlein, Genie Alvarez, Rebecca Gale, Taylor Dupuy, Katherine Makaroff, Garth Fuller, Xiaoyu Liu, Kyung-Sang Yu, J T Black, Mariko Ishimori, Swamy Venuturupalli, Joseph Tu, Tom Norris, Mourad Tighiouart, Lindsey Ross, Karma McKelvey, Mark V

BMJ open. 2021,Jun;15;11(6):e050545. doi: 10.1136/bmjopen-2021-050545.
48

Metabolic fingerprinting uncovers the distinction between the phenotypes of tuberculosis-associated COPD and smoking-induced COPD

Da Jung Kim, Jee Youn Oh, Chin Kook Rhee, Seoung Ju Park, Jae Jeong Shim, Joo-Youn Cho

Frontiers in medicine. 2021,May;14;8:619077. doi: 10.3389/fmed.2021.619077.
49

Assessment of Oral Vancomycin-Induced Alterations in Gut Bacterial Microbiota and Metabolome of Healthy Men

Andrew HyoungJin Kim, Yujin Lee, Eunwoo Kim, Sang Chun Ji, Jae-Yong Chung, Joo-Youn Cho

Frontiers in cellular and infection microbiology. 2021,May;27;11:629438. doi: 10.3389/fcimb.2021.629438.
50

Impact of a computerised clinical decision support system on vancomycin loading and the risk of nephrotoxicity

June Young Chun, Kyoung-Ho Song, Dong-Eun Lee, Joo-Hee Hwang, Hyun Gul Jung, Eunjeong Heo, Hyung-Sook Kim, Seonghae Yoon, Jeong Su Park, Pyoeng Gyun Choe, Jae-Yong Chung, Wan Beom Park, Ji Hwan Bang, Hee Hwang, Kyoung-Un Park, Sang Won Park, Nam Joong Kim, Myoung-Do, Eu Suk Kim, Hong Bin Kim

International journal of medical informatics. 2021,May;149:104403. doi: 10.1016/j.ijmedinf.2021.104403.
51

A target-mediated drug disposition population pharmacokinetic model of GC1118, a novel anti-EGFR antibody, in patients with solid tumors

Tae Kyu Chun, Hyun A Lee, Sang-In Park, Do-Youn Oh, Keun-Wook Lee, Jin Won Kim, Jee Hyun Kim, Ahmi Woo, Su Jin Lee, Yung-Jue Bang, Howard Lee

Clinical and translational science. 2021,May;14(3):990-1001. doi: 10.1111/cts.12963.
52

Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers

Deok Y Yoon, Jung Sunwoo, Naree Shin, Ah R Kim, Bongtae Kim, Geun S Song, In-Jin Jang, SeungHwan Lee

Clinical and translational science. 2021,May;14(3):934-941. doi: 10.1111/cts.12958. Epub 2021 Jan 21.
53

A pilot study to investigate the utility of NAT2 genotype-guided isoniazid monotherapy regimens in NAT2 slow acetylators

Hyounggyoon Yoo, Sang Chun Ji, Joo-Youn Cho, Sang-Heon Kim, Jihoon G Yoon, Min Goo Lee, Kyung-Sang Yu, In-Jin Jang, Jaeseong Oh

Pharmacogenet Genomics. 2021,Apr;1;31(3):68-73. doi: 10.1097/FPC.0000000000000423.
54

Safety, pharmacokinetics and pharmacodynamics of BI 655064 in phase 1 clinical trials in healthy Chinese and Japanese subjects

Yasuhiro Tsuda, Christine Grimaldi, Fenglei Huang, Ewald Benediktus, Nobutaka Yagi, Steven J Padula, In-Jin Jang, Jürgen Steffgen

Br J Clin Pharmacol . 2021,Apr; doi: 10.1111/bcp.14601. Online ahead of print.
55

Population Pharmacokinetic Modelling and Simulation to Determine the Optimal Dose of Nanoparticulated Sorafenib to the Reference Sorafenib

Ki Young Huh, Sejung Hwang, Sang Yeob Park, Hye Jung Lim, Miryung Jin, Jaeseong Oh, Kyung Sang Yu, Jae Yong Chung

Pharmaceutics 2021,Apr; 28;13(5):629. doi: 10.3390/pharmaceutics13050629.
56

Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP ®) Biosimilar, to Those of NESP ® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects

Inseung Jeon, Jaeseong Oh, Yu-Kyung Kwon, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug design, development and therapy. 2021,Apr;28;15:1735-1747. doi: 10.2147/DDDT.S303772. eCollection 2021.
57

Population pharmacokinetic/pharmacodynamic modeling of delayed effect of escitalopram-induced QT prolongation

Yun Kim, Anhye Kim, Jae-Yong Chung

Journal of affective disorders. 2021,Apr;15;285:120-126. doi: 10.1016/j.jad.2021.02.048.
58

YH12852, a Potent and Selective Receptor Agonist of 5-hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation

Hyun A Lee, Seol Ju Moon, Hyounggyoon Yoo, Mi Kyung Kim, Seong Bok Jang, Seoungoh Lee, Sohee Kim, Howard Lee

Clinical and translational science. 2021,Mar;14(2):625-634. doi: 10.1111/cts.12924.
59

Pharmacokinetic comparison between tablet of varenicline tartrate and orally disintegrating film of varenicline salicylate in healthy subjects

Eunwoo Kim, Jun Gi Hwang, Su Jun Park, Ji Young Han, Young-Sim Choi, Se-Rin Park, Kyung-Sang Yu, Min Kyu Park, SeungHwan Lee

Int J Clin Pharmacol Ther . 2021,Mar;11. doi: 10.5414/CP203953. Online ahead of print.
60

Pharmacokinetics and Safety of Extended-release Ranolazine in Korean and White Healthy Subjects

Hyounggyoon Yoo, Sang Won Lee, Deok Yong Yoon, Seo Hyun Yoon, Joo-Youn Cho, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Clinical therapeutics. 2021,Mar;43(3):526-534.e4. doi: 10.1016/j.clinthera.2021.01.005.
61

Pharmacokinetic Interaction Among Ezetimibe, Rosuvastatin, and Telmisartan

Ki Young Huh, Sang Won Lee, Si Beum Lee, Kyung Tae Kim, In-Jin Jang, SeungHwan Lee

Clinical pharmacology in drug development. 2021,Mar; 1. doi: 10.1002/cpdd.926. Online ahead of print.
62

Pharmacokinetics and tolerability of apremilast in healthy Korean adult males

Ki Young Huh, Yewon Choi, Jim Nissel, Maria Palmisano, Xiaomin Wang, Liangang Liu, Francisco Ramirez-Valle, Howard Lee

Clinical and translational science. 2021,Mar;1. doi: 10.1111/cts.13013. Online ahead of print.
63

Current bioequivalence study designs in South Korea: a comprehensive analysis of bioequivalence study reports between 2013 and 2019

Ki Young Huh, Eunwoo Kim, Soyoung Lee, Hyounggyoon Yoo, Seonghae Yoon, Kyung-Sang Yu, Jae-Yong Chung

Frontiers in pharmacology. 2021,Mar;4;12:651790. doi: 10.3389/fphar.2021.651790. eCollection 2021.
64

Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects

Jihyun Jung, Soyoung Lee, Jaeseong Oh, SeungHwan Lee, In-Jin Jang, Donghwan Lee, Kyung-Sang Yu

Translational and clinical pharmacology. 2021,Mar;29(1):53-64. doi: 10.12793/tcp.2021.29.e5. Epub 2021 Mar 22.
65

A meta-analysis: efficacy and safety of anti-epileptic drugs prescribed in Korea as monotherapy and adjunctive treatment for patients with focal epilepsy

JuYeun Jeon, Jaeseong Oh, Kyung-Sang Yu

Translational and clinical pharmacology. 2021,Mar;29(1):6-20. doi: 10.12793/tcp.2021.29.e1.
66

Comparative pharmacokinetics between tenofovir disoproxil phosphate and tenofovir disoproxil fumarate in healthy subjects

Sangmi Lee, Eunwoo Kim, Seol Ju Moon, Jina Jung, SeungHwan Lee, Kyung-Sang Yu

Translational and clinical pharmacology. 2021,Mar;29(1):45-52. doi: 10.12793/tcp.2021.29.e4.
67

Population pharmacokinetic model development and its relationship with adverse events of oxcarbazepine in adult patients with epilepsy

Yoonhyuk Jang, Seonghae Yoon, Tae-Joon Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Kon Chu, Sang Kun Lee

Scientific reports. 2021,Mar;18;11(1):6370. doi: 10.1038/s41598-021-85920-0.
68

Effects of perampanel on cognition and quantitative electroencephalography in patients with epilepsy

Seon-Jae Ahn, Tae-Joon Kim, Kwang Su Cha, Jin-Sun Jun, Jung-Ick Byun, Yong-Won Shin, Jun-Sang Sunwoo, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Kon Chu, Sang Kun Lee, Ki-Young Jung

Epilepsy Behav . 2021,Feb;115:107514. doi: 10.1016/j.yebeh.2020.107514. Epub 2020 Dec 14.
69

Tolerability of lacosamide rapid dose titration: A randomized, multicenter, prospective, open-label study

Yong-Won Shin, Jangsup Moon, Yong Won Cho, Dong Wook Kim, Sang Bin Hong, Do-Yong Kim, Hyeyeon Chang, Seo Hyun Yoon, Kyung-Sang Yu, In-Jin Jang, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Kon Chu, SeungHwan Lee, Sang Kun Lee

Epilepsy Behav . 2021,Feb;115:107663. doi: 10.1016/j.yebeh.2020.107663.
70

Urinary metabolic markers reflect on hepatic, not intestinal, CYP3A activity in healthy subjects

Soyoung Lee, Yujin Lee, Andrew HyoungJin Kim, Sumin Yoon, Jieon Lee, Sang Chun Ji, Seo Hyun Yoon, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho

Drug Metab Pharmacokinet . 2021,Feb;3;36:100374
71

The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects

Soyoung Lee, Andrew HyoungJin Kim, Sumin Yoon, Jieon Lee, Yujin Lee, Sang Chun Ji, Seo Hyun Yoon, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho

Drug Metab Pharmacokinet . 2021,Feb;12;36:100368
72

Comparison of the Pharmacokinetics of a Fixed-Dose Combination of Rosuvastatin/Metformin Sustained-Release (10/1000 mg) and Separate Tablets in Healthy Male Subjects

Ki Young Huh, Eunwoo Kim, Heechan Lee, Inseung Jeon, Hearan Suh, Jongsun Lee, Yunhee Lee, Kyung-Sang Yu, SeungHwan Lee

Clin Pharmacol Drug Dev . 2021,Feb;10(2):207-213. doi: 10.1002/cpdd.841.
73

Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study

Eunsol Yang, Hyounggyoon Yoo, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug design, development and therapy. 2021,Feb;17;15:651-658. doi: 10.2147/DDDT.S288986. eCollection 2021.
74

Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells

Jieun Seo, Kyeong Seog Kim, Jong-Wan Park, Joo-Youn Cho, Hak Chang, Junji Fukuda, Ki Yong Hong, Yang-Sook Chun

Biomaterials. 2021,Feb;269:120622. doi: 10.1016/j.biomaterials.2020.120622.
75

The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis

Yujin Lee, Eun Lee, Dong Keon Yon, Hye Mi Jee, Hey Sung Baek, Seung Won Lee, Joo-Youn Cho, Man Yong Han

Scientific reports. 2021,Feb;12;11(1):3772. doi: 10.1038/s41598-021-83288-9.
76

Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function

Seonghae Yoon, Heechan Lee, Sang-Chun Ji, Seo Hyun Yoon, Joo-Youn Cho, Jae-Yong Chung

Clin Pharmacol Drug Dev . 2021,Jan;doi: 10.1002/cpdd.790. Online ahead of print.
77

Optimization and validation of a fluorogenic dipeptidyl peptidase 4 enzymatic assay in human plasma

Hyunyee Yoon, Su Hee Cho, Yu Rim Seo, Kyung-Sang Yu, Sung Sup Park, Moon Jung Song

Anal Biochem . 2021,Jan;1;612:113952. doi: 10.1016/j.ab.2020.113952. Epub 2020 Sep 12.
78

An Investigation of the Metabolism and Excretion of KD101 and Its Interindividual Differences: A Microtracing Mass Balance Study in Humans

Anhye Kim, Stephen R. Dueker, Jun Gi Hwang, Jangsoo Yoon, Sang‐Won Lee, Hye Suk Lee, Byung‐Yong Yu, Kyung‐Sang Yu, Howard Lee

Clin Transl Sci . 2021,Jan;14(1):231-238. doi: 10.1111/cts.12848. Epub 2020 Sep 26.
79

Pharmacokinetic equivalence of CT-P17 to high-concentration (100 mg/ml) reference adalimumab: A randomized phase I study in healthy subjects

Kyung-Sang Yu, In-Jin Jang, Hyeong-Seok Lim, Jang Hee Hong, Min-Gul Kim, Min Kyu Park, Doo-Yeoun Cho, Min Soo Park, Jae Yong Chung, Jong-Lyul Ghim, SeungHwan Lee, Seok Kyu Yoon, In Sun Kwon, Sang Joon Lee, Sung Hyun Kim, Yun Ju Bae, Jung Bin Cha, Daniel E Furst

Clin Transl Sci. 2021,Jan;27. doi: 10.1111/cts.12967.
80

Pharmacodynamics and pharmacokinetics of DWP14012 (fexuprazan) in healthy subjects with different ethnicities

Jun Gi Hwang, Inseung Jeon, Sun Ae Park, Areum Lee, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Aliment Pharmacol Ther . 2020,Dec;52(11-12):1648-1657
81

Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects

Jung Sunwoo, Sang Chun Ji, Jaeseong Oh, Mu Seong Ban, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Aliment Pharmacol Ther . 2020,Dec;52(11-12):1640-1647
82

Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers

Sang Won Lee, Jaeseong Oh, Andrew HyoungJin Kim, Sang Chun Ji, Sang-In Park 4, Seo Hyun Yoon, Jae-Young Chung, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Pharmacogenomics J . 2020,Dec;20(6):792-800
83

Gut microorganisms and their metabolites modulate the severity of acute colitis in a tryptophan metabolism-dependent manner

Ji-Hee Shin , Young-Kwan Lee, Woo-Jeong Shon, Bora Kim, Che Ok Jeon, Joo-Youn Cho, Herbert C Morse 3rd, Eun Young Choi, Dong-Mi Shin

Eur J Nutr . 2020,Dec;59(8):3591-3601.
84

Electronic medical records-based comparison of glycemic control efficacy between sulfonylureas and dipeptidyl peptidase-4 inhibitors added on to metformin monotherapy in patients with type 2 diabetes

Suhrin Lee , SeungHwan Lee , In-Jin Jang , Kyung-Sang Yu , and Su-jin Rhee

Transl Clin Pharmacol . 2020,Dec;2020 Dec;28(4):199-207. doi: 10.12793/tcp.2020.28.e21. Epub 2020 Dec 18.
85

Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers

Yoon DY, Sunwoo J, Shin N, Kim AR, Kim B, Song GS, Jang IJ, Lee S.

Clin Transl Sci 2020,Dec;2020 Dec 31. doi: 10.1111/cts.12958. Online ahead of print.
86

Pharmacogenomic information from CPIC and DPWG guidelines and its application on drug labels

Yoon DY, Lee S, Ban MS, Jang IJ, Lee S.

Transl Clin Pharmacol 2020,Dec; 2020 Dec;28(4):189-198. doi: 10.12793/tcp.2020.28.e18. Epub 2020 Dec 11.
87

Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects

Hyounggyoon Yoo, Yun Kim, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug Des Devel Ther . 2020,Nov; 24;14:5179-5187
88

Multiple-dose pharmacokinetics and safety of amoxicillin/clavulanate in healthy elderly subjects

Sang Won Lee, Yewon Choi, Kyungho Jang, Seo Hyun Yoon, Jae-Yong Chung

Int J Clin Pharmacol Ther . 2020,Nov;58(11):634-641
89

Population Pharmacokinetic Analysis of Amikacin for Optimal Pharmacotherapy in Korean Patients with Nontuberculous Mycobacterial Pulmonary Disease

Xuanyou Jin, Jaeseong Oh, Joo-Youn Cho, SeungHwan Lee, Su-Jin Rhee

Antibiotics (Basel) . 2020,Nov;6;9(11):784
90

hIL-7-hyFc, A Long-Acting IL-7, Increased Absolute Lymphocyte Count in Healthy Subjects

Sang Won Lee, Donghoon Choi, MinKyu Heo, Eui-Cheol Shin, Su-Hyung Park, So Jeong Kim, Yeon-Kyung Oh, Byung Ha Lee , Se Hwan Yang, Young Chul Sung, Howard Lee

Clinical and translational science. 2020,Nov;2020 Nov;13(6):1161-1169. doi: 10.1111/cts.12800. Epub 2020 May 20.
91

Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects

Inyoung Hwang, Yun Kim, Hyounggyoon Yoo, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug Des Devel Ther . 2020,Oct;23;14:4493-4502
92

Pharmacokinetics and Tolerability of LC28-0126, a Novel Necrosis Inhibitor, After Multiple Ascending Doses: A Phase I Randomized, Double-blind, Placebo-controlled Study in Healthy Male Subjects

Eunwoo Kim, Inyoung Hwang, SeungHwan Lee, Jaeseong Oh, Hyewon Chung, Myungwon Jin, Soon Ha Kim, Kyung-Sang Yu

Clin Ther . 2020,Oct;42(10):1946-1954.e2
93

Development of a Pharmacokinetic Model Describing Neonatal Fc Receptor-Mediated Recycling of HL2351, a Novel Hybrid Fc-Fused Interleukin-1 Receptor Antagonist, to Optimize Dosage Regimen

Lien Ngo, Jaeseong Oh, Anhye Kim, Hyun-Moon Back, Won-Ho Kang, Jung-Woo Chae, Hwi-Yeol Yun, Howard Lee

CPT Pharmacometrics Syst Pharmacol . 2020,Oct;9(10):584-595
94

The Impact of COVID-19 on the Conduct of Clinical Trials for Medical Products in Korea

JuYeun Jeon, Hyeikyoung Kim, Kyung Sang Yu

J Korean Med Sci . 2020,Sep;14;35(36):e329
95

Impact of Vancomycin-Induced Changes in the Intestinal Microbiota on the Pharmacokinetics of Simvastatin

Jung Sunwoo, Sang Chun Ji, Andrew HyoungJin Kim, Kyung-Sang Yu, Joo-Youn Cho, In-Jin Jang, SeungHwan Lee

Clin Transl Sci . 2020,Jul;13(4):752-760
96

Usefulness of saliva for perampanel therapeutic drug monitoring

Do-Yong Kim, Jangsup Moon, Yong-Won Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, KaHeon Song, Kon Chu, Sangkun Lee

Epilepsia . 2020,Jun;61(6):1120-1128
97

Comparative pharmacokinetics of a montelukast/levocetirizine fixed-dose combination chewable tablet versus individual administration of montelukast and levocetirizine after a single oral administration in healthy Korean male subjects

Seol Ju Moon, Kyung-Sang Yu, Jina Jung, Yong-Il Kim, Min-Gul Kim

Int J Clin Pharmacol Ther . 2020,Jun;58(6):354-362.
98

An Assessment of Pharmacokinetic Interaction Between Lobeglitazone and Sitagliptin After Multiple Oral Administrations in Healthy Men

Seol Ju Moon, Kyung-Sang Yu, Min-Gul Kim

Clin Ther . 2020,Jun;42(6):1047-1057
99

Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A

Yujin Lee, Woori Chae, Seonghae Yoon, Jae-Yong Chung, Joo-Youn Cho

Transl Clin Pharmacol . 2020,Jun;28(2):73-82
100

Common data model-based real-world data for practical clinical practice guidelines: clinical pharmacology perspectives

Yoomin Jeon, Yoona Choi, Esther Hehsun Kim, SeonYeong Oh, Howard Lee

Translational and Clinical Pharmacology 2020,Jun;2020 Jun;28(2):67-72. doi: 10.12793/tcp.2020.28.e11. Epub 2020 Jun 25.
101

Pharmacokinetics of human antithrombin III concentrate in the immediate postoperative period after liver transplantation

Bo Rim Kim, Jaeseong Oh, Kyung-Sang Yu, Ho Geol Ryu

Br J Clin Pharmacol . 2020,May;86(5):923-932
102

Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets

Jun Gi Hwang, Kyung-Sang Yu, SeungHwan Lee

Drug Des Devel Ther . 2020,May;20;14:1953-1961
103

Author Response: Does the Fc Region Have a Role in the Ocular Half-Life After Intravitreal Injection?

Kwangsic Joo, Yewon Choi, Jae-Yong Chung, Se Joon Woo

Invest Ophthalmol Vis Sci . 2020,May;11;61(5):21
104

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Hyeong Min Kim, Seungmin Ha, Hye Kyoung Hong, Yoonha Hwang, Pilhan Kim 3 4 5, Eunsol Yang 6, Jae Yong Chung 6, Sunyoung Park, Young Joo Park, Kyu Hyung Park, Hyuncheol Kim, Se Joon Woo

Transl Vis Sci Technol . 2020,May;20;9(6):20.
105

External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old

Sang Hwan Ji, Ji Hyun Lee, Joo Youn Cho, Hwa Suk Kim, Young Eun Jang, Eun Hee Kim, Jin Tae Kim, Hee Soo Kim

J Korean Med Sci . 2020,May;2020 Mar 23;35(11):e70. doi: 10.3346/jkms.2020.35.e70.
106

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

Je-Hwan Lee, Stefan Faderl, John M Page, Chul Won Jung, Sung-Soo Yoon 5, Animesh D Pardanani 6, Pamela S Becker 7, Howard Lee, Jeongeun Choi, Kyoungjune Lee, Minkyoung Kim, Jorge E Cortes

Blood advances. 2020,May;2020 May 12;4(9):2032-2043. doi: 10.1182/bloodadvances.2019000757.
107

Phase I and pharmacokinetic study of the vascular-disrupting agent CKD-516 (NOV120401) in patients with refractory solid tumors

Hark Kyun Kim, Jeong Won Kang, Young-Whan Park, Jung Young Kim, Minchae Kim, Soo Jin Kim, Se-Mi Kim, Keun Ho Ryu, Seonghae Yoon, Yun Kim, Joo-Youn Cho, Keun Seok Lee, Tak Yun, Kiwon Kim, Mi Hyang Kwak, Tae-Sung Kim, Jinsoo Chung, Joong-Won Park

Pharmacol Res Perspect . 2020,Apr;8(2):e00568
108

Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis

Kyoung Hee Han, Bora Kim, Sang Chun Ji, Hee Gyung Kang, Hae Il Cheong, Joo-Youn Cho, Il-Soo Ha

Metabolites . 2020,Apr;24;10(4):169
109

A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli

Juha Song, Dohyun Han, Heonyi Lee, Da Jung Kim, Joo-Youn Cho, Jae-Hak Park, Seung Hyeok Seok

Int J Mol Sci . 2020,Apr;25;21(9):3037
110

Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea

Hee Kyung Kim, Su Mi Choi, Gaeun Kang, Kyung Hwa Park, Dong Gun Lee 3, Wan Beom Park, Su Jin Rhee, SeungHwan Lee, Sook In Jung, Hee Chang Jang

Yonsei Med J . 2020,Apr;61(4):301-309
111

A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMET TM Plus Platform

Jeong-An Gim, Yonghan Kwon, Hyun A Lee, Kyeong-Ryoon Lee, Soohyun Kim, Yoonjung Choi, Yu Kyong Kim, Howard Lee

Int J Mol Sci . 2020,Apr;2020 Apr 4;21(7):2517. doi: 10.3390/ijms21072517.
112

The road to biosimilars in rare diseases - ongoing lessons from Gaucher disease

Guillermo Drelichman, Gilberto Castañeda-Hernández, Muhlis Cem Ar, Marta Dragosky, Ricardo Garcia, Howard Lee, Sergey Moiseev, Majid Naderi, Hanna Rosenbaum, Ir Selena Freisens, Pramod K Mistryena Žnidar, Andrés Felipe Zuluaga,

Am J Hematol . 2020,Mar;95(3):233-237
113

Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans

Thi Lien Ngo, Chung-Hee Lee, Nayoung Han, Hyun-Moon Back, Su-Jin Rhee, Keumhan Noh, Hwi-Yeol Yun, Wonku Kang, Jung-Woo Chae

Int J Mol Sci . 2020,Mar; 9;21(5):1862
114

Pharmacokinetics and pharmacodynamics of a fixed-dose combination of gemigliptin/metformin sustained release 25/500 mg compared to the loose combination in healthy male subjects

Xuanyou Jin, Eunwoo Kim, Ki Young Huh, Inyoung Hwang, Joo-Youn Cho, Kyung-Sang Yu, SeungHwan Lee

Transl Clin Pharmacol . 2020,Mar;2020 Mar;28(1):43-54. doi: 10.12793/tcp.2020.28.e2. Epub 2020 Mar 30.
115

Altered Gene Expression Profiles in Peripheral Blood Mononuclear Cells in Obese Subjects

Kyungho Jang, Tao Tong, Jinhui Lee, Taesun Park, Howard Lee

Obesity facts. 2020,Mar;2020;13(3):375-385. doi: 10.1159/000507817. Epub 2020 Jun 16.
116

Intraocular Pharmacokinetics of 10-fold Intravitreal Ranibizumab Injection Dose in Rabbits

Hyeong Min Kim, Young Joo Park , Simin Lee, Joo Young Son, Hye Kyoung Hong, Min Hee Ham, Xuanyou Jin, Jae Yong Chung, Kyu Hyung Park, Ki Dong Park Se Joon Woo

Transl Vis Sci Technol . 2020,Mar;2020 Mar 9;9(4):7. doi: 10.1167/tvst.9.4.7. eCollection 2020 Mar.
117

Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers.

Yoon DY, Park SI, Jung JA, Kim YI, Jang IJ, Chung JY.

Drug Des Devel Ther. 2020,Feb;19;14:661-668.
118

Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles.

Kim DJ, Yang J, Seo H, Lee WH, Ho Lee D, Kym S, Park YS, Kim JG, Jang IJ, Kim YK, Cho JY

Sci Rep 2020,Feb;18;10(1):2860
119

Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer's disease animal model

Hyunju Kim, Bora Kim, Hye-Sun Kim, Joo-Youn Cho

Mol Brain. 2020,Feb;7;13(1):17
120

Safety, tolerability and pharmacokinetics and pharmacodynamics of HL2351, a novel hybrid fc-fused interleukin-1 receptor antagonist, in healthy subjects: A first-in-human study

Jaeseong Oh, Ki Young Huh, Young-Gyu Cho, Ji-Eun Cha, Se-Jin Kim, Seo Hyun Yoon, Sung Sup Park, Hyunyee Yoon, Jieon Lee, Howard Lee

Br J Clin Pharmacol . 2020,Feb;86(2):372-379
121

Pharmacokinetics of high-dose carboplatin in children undergoing high-dose chemotherapy and autologous stem cell transplantation with BSA-based dosing

Che Ry Hong, Hyoung Jin Kang, Seol Ju Moon, Jaeseong Oh, Kyung Taek Hong, Jung Yoon Choi, Kyung-Sang Yu, Hee Young Shin

Bone Marrow Transplant . 2020,Jan;55(1):137-146
122

A Prediction Model for the Intraocular Pharmacokinetics of Intravitreally Injected Drugs Based on Molecular Physicochemical Properties

Hyeong Min Kim, Kyu Hyung Park, Jae Yong Chung, Se Joon Woo

Ophthalmic Res . 2020,Jan;63(1):41-49.
123

Human ADME for YH12852 using wavelength scanning cavity ring-down spectroscopy (WS-CRDS) after a low radioactivity dose

Anhye Kim, Stephen R Dueker, Feng Dong, Ad F Roffel, Sang-Won Lee, Howard Lee

BIOANALYSIS 2020,Jan;2020 Jan;12(2):87-98. doi: 10.4155/bio-2019-0119.
124

Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects.

Kim Y, Yoon S, Choi Y, Yoon SH, Cho JY, Jang IJ, Yu KS, Chung JY

Sci Rep 2019,Dec;19;9(1):19410.
125

Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects.

Yang E, Lee S, Lee H, Hwang I, Jang IJ, Yu KS, Lee S

Transl Clin Pharmacol 2019,Dec;27(4):134-140
126

Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects

Yun Kim, Seonghae Yoon, Yewon Choi, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung

Scientific reports. 2019,Dec;2019 Dec 19;9(1):19410. doi: 10.1038/s41598-019-55562-4.
127

Pharmacokinetic Interaction Among Telmisartan, Amlodipine, and Hydrochlorothiazide After a Single Oral Administration in Healthy Male Subjects.

Moon SJ, Jeon JY, Yu KS, Kim MG

Clin Ther. 2019,Nov;41(11):2273-2282
128

Author Correction: Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction.

Kim DJ, Yoon S, Ji SC, Yang J, Kim YK, Lee S, Yu KS, Jang IJ, Chung JY, Cho JY

Sci Rep. 2019,Nov;13;9(1):17003
129

A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects.

Kim E, Park KR, Jang IJ, Yu KS, Lee S

Drug Des Devel Ther 2019,Nov;13;13:3879-3885
130

Influence of midazolam-related genetic polymorphism on conscious sedation during upper gastrointestinal endoscopy in a Korean population.

Park JY, Kim BJ, Lee SW, Kang H, Kim JW, Jang IJ, Kim JG

Sci Rep 2019,Nov;5;9(1):16001
131

URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers

Hyun A Lee, Kyung-Sang Yu, Sang-In Park, Seonghae Yoon, Makoto Onohara, Youngjoo Ahn, Howard Lee

Rheumatology. 2019,Nov;2019 Nov 1;58(11):1976-1984. doi: 10.1093/rheumatology/kez140.
132

A safety, pharmacokinetic, pharmacogenomic and population pharmacokinetic analysis of the third-generation EGFR TKI, olmutinib (HM61713), after single oral administration in healthy volunteers.

Young Su Noh, Seonghae Yoon, Suk Ran Kim, Kyung‐Tae Lee, In‐Jin Jang

Basic Clin Pharmacol Toxicol 2019,Oct;125(4):370-381
133

Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis.

Kim DJ, Cho EJ, Yu KS, Jang IJ, Yoon JH, Park T, Cho JY

Cancers (Basel) 2019,Oct;6;11(10)
134

ST2 blockade mitigates peritoneal fibrosis induced by TGF-β and high glucose.

Kim YC, Kim KH, Lee S, Jo JW, Park JY, Park MS, Tsogbadrakh B, Lee JP, Lee JW, Kim DK, Oh KH, Jang IJ, Kim YS, Cha RH, Yang SH

J Cell Mol Med 2019,Oct;23(10):6872-6884
135

Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages

Hee Young Kim, Tae-Hyun Yoo, Joo-Youn Cho, Hyeon Chang Kim, Won-Woo Lee

FASEB J . 2019,Oct;2019 Oct;33(10):10844-10858. doi: 10.1096/fj.201900730R. Epub 2019 Jul 5.
136

Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment.

Yoon S, Yi S, Rhee SJ, Lee HA, Kim Y, Yu KS, Chung JY

Transl Clin Pharmacol. 2019,Sep;27(3):107-114
137

Artificial intelligence in drug development: clinical pharmacologist perspective.

Jang IJ

Transl Clin Pharmacol 2019,Sep;27(3):87-88.
138

Safety, tolerability, and anti-tumor activity of olmutinib in non-small cell lung cancer with T790M mutation: A single arm, open label, phase 1/2 trial.

Kim DW, Lee DH, Han JY, Lee J, Cho BC, Kang JH, Lee KH, Cho EK, Kim JS, Min YJ, Cho JY, An HJ, Kim HG, Lee KH, Kim BS, Jang IJ, Yoon S, Han O, Noh YS, Hong KY, Park K

Lung Cancer 2019,Sep;135:66-72
139

Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population.

Lee S, Yoon S, Chung H, Ji SC, Yoon SH, Yu KS, Cho JY, Chung JY

Journal of clinical pharmacology 2019,Aug;59(8):1085-1092.
140

Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers.

Lee J, Yoon SH, Yi S, Kim AH, Kim B, Lee S, Yu KS, Jang IJ, Cho JY

Drug metabolism and pharmacokinetics 2019,Aug;34(4):247-252
141

Pharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under fasted and fed conditions in healthy volunteers.

Shin D, Park SI, Lee HS, An KM, Jung J, Lee M, Yu KS

Drug Des Devel Ther. 2019,Jul; 24;13:2483-2490
142

Pharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects.

Moon SJ, Jeon JY, Jang K, Yu KS, Lim Y, Kim MG

Drug Des Devel Ther. 2019,Jul;25;13:2533-2542
143

Use of Molecular Imaging in Clinical Drug Development: a Systematic Review.

Hyeomin Son, Kyungho Jang, Heechan Lee, Sang Eun Kim, Keon Wook kang, Howard lee

Nuclear medicine and molecular imaging 2019,Jun;53(3):208-215.
144

A First-in-Human Phase I Study of GC1118, a Novel Anti-Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors.

"DO-YOUN OH, KEUN-WOOK LEE, SAE-WON HAN, JIN WON KIM, JUNG-WON SHIN, SEONG-JIN JO, JONGHWA WON, SEOKYUNG HAHN, HOWARD LEE, WOO HO KIM, YUNG-JUE BANG"

The oncologist 2019,Jun; pii: theoncologist.2019-0294.
145

Challenges and insights of early oncology drug development in the Asia-Pacific region: introduction of phase I oncology clinical trial center and experience sharing for early clinical trials in Seoul National University Hospital, Korea.

Im SA, Lee DW, Kang R, Kim JH, Kim DW, Jang IJ, Lee JS, Bang YJ

Chin Clin Oncol 2019,Jun;8(3):27
146

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients

Eun-Sook Park, Ah Ram Lee, Doo Hyun Kim, Jeong-Hoon Lee, Jeong-Ju Yoo 3, Sung Hyun Ahn, Heewoo Sim, Soree Park, Hong Seok Kang, Juhee Won, Yea Na Ha 1, Gu-Choul Shin 1, So Young Kwon 4, Yong Kwang Park 5, Byeong-Sun Choi, Yun Bin Lee, Nakcheol Jeong, Yohan An, Young Seok Ju,Su Jong Yu, Hee Bok Ch

J Hepatol . 2019,Jun; 2019 Jun;70(6):1093-1102. doi: 10.1016/j.jhep.2019.02.006. Epub 2019 Feb 20.
147

A Population Pharmacokinetic Study of Prophylactic Fluconazole in Preterm Infants for Prevention of Invasive Candidiasis

Kim YK, Lee J, Oh J, Rhee SJ, Shin SH, Yoon SH, Lee S, Kim HS, Yu KS

Antimicrobial agents and chemotherapy 2019,May;24;63(6).
148

URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers.

Hyun A Lee, Kyung-Sang Yu, Sang-In Park, Seonghae Yoon, Makoto Onohara, Youngjoo Ahn, Howard Lee

Rheumatology. 2019,May; pii: kez140.
149

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry.

Kim JS, Kim AH, Jang C, Jang IJ, Kim KB, Cho JY, Hwang HY

Journal of Korean medical science 2019,Apr;8;34(13):e104.
150

Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects

Dongseong Shin, Young Sil Eom, Suk Chon, Byung-Joon Kim, Kyung-Sang Yu, Dae Ho Lee

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019,Apr; 10;12:469-476.
151

Development of a Korean-specific virtual population for physiologically based pharmacokinetic modelling and simulation.

Yun Kim Oliver Hatley Su‐jin Rhee Sojeong Yi Hyun A. Lee Sumin Yoon Jae‐Yong Chung Kyung‐Sang Yu Howard Lee

Biopharmaceutics & drug disposition 2019,Apr;40(3-4):135-150.
152

A Rapid Method to Estimate Hepatocyte Loss Due to Drug-Induced Liver Injury.

Chung JY, Longo DM, Watkins PB

Clinical pharmacology and therapeutics 2019,Mar;105(3):746-753.
153

A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K+-competitive acid blocker.

Lee HA, Lee KR, Jang SB, Chung SY, Yu KS, HL

European journal of pharmaceutical sciences 2019,Mar;15;130:1-10.
154

Pharmacokinetics of fludarabine and its association with clinical outcomes in paediatric haematopoietic stem cell transplantation patients

Chung H, Hong KT, Lee JW, Rhee SJ, Kim S, Yoon SH, Yu KS, Kang HJ

Bone Marrow Transplant. 2019,Feb;2019 Feb;54(2):284-292. doi: 10.1038/s41409-018-0260-z. Epub 2018 Jun 18.
155

Pharmacokinetic characteristics and limited sampling strategies for therapeutic drug monitoring of colistin in patients with multidrug-resistant Gram-negative bacterial infections.

Kim EJ, Oh J, Lee K, Yu KS, Chung JY, Hwang JH, Nam EY, Kim HS, Kim M, Park JS, Song KH, Kim ES, Song J, Kim HB

Therapeutic drug monitoring 2019,Feb;41(1):102-106.
156

A Personalized CYP2C19 Phenotype-Guided Dosing Regimen of Voriconazole Using a Population Pharmacokinetic Analysis

Kim Y, Rhee SJ, Park WB, Yu KS, Jang IJ, Lee S

Journal of clinical medicine 2019,Feb;10;8(2).
157

AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway.

Tsogbadrakh B, Ryu H, Ju KD, Lee J, Yun S, Yu KS, Kim HJ, Ahn C, Oh KH

Biochemical and biophysical research communications 2019,Feb;12;509(3):680-686.
158

Pharmacokinetic comparison of gemigliptin 50 mg and metformin 500 mg as a fixed-dose combination and loose combination 

Lee SW, Park SI, Lee S, Chung JY, Yu KS

International journal of clinical pharmacology and therapeutics 2019,Feb;57(2):117-124.
159

Ursodeoxycholic acid exerts hepatoprotective effects by regulating amino acid, flavonoid, and fatty acid metabolic pathways

Da Jung Kim , Hyewon Chung, Sang Chun Ji, SeungHwan Lee,Kyung‑Sang Yu, In‑Jin Jang, Joo‑Youn Cho

Metabolomics Society 2019,Feb;27;15(3):30.
160

Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia

Soo Young Moon, Ji-Hyun Lim, Eun-Hee Kim, Youngwon Nam, Kyung-Sang Yu, Kyung Taek Hong 3 4, Jung Yoon Choi, Che Ry Hong, Hyery Kim, Hyoung Jin Kang, Hee Young Shin, Kyunghoon Lee, Junghan Song, Soo-Youn Lee, Sang Hoon Song

Ther Drug Monit . 2019,Feb;2019 Feb;41(1):75-85. doi: 10.1097/FTD.0000000000000575.
161

What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing.

Polasek TM, Rostami-Hodjegan A, Yim DS, Jamei M, Lee H, Kimko H, Kim JK, Nguyen PTT, Darwich AS, Shin JG

The AAPS journal 2019,Jan;9;21(2):17.
162

OCT3 promoter haplotype is associated with metformin pharmacokinetics in Koreans

Kim EJ, Oh J, Lee K, Yu KS, Chung JY, Hwang JH, Nam EY, Kim HS, Kim M, Park JS, Song KH, Kim ES, Song J, Kim HB

Scientific reports 2018,Nov;16;8(1):16965.
163

Physiologically Based Pharmacokinetic Modeling of Fimasartan, Amlodipine, and Hydrochlorothiazide for the Investigation of Drug-Drug Interaction Potentials

Rhee SJ, Lee HA, Lee S, Kim E, Jeon I, Song IS, Yu KS

Pharmaceutical research. 2018,Oct;15;35(12):236.
164

Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment.

Kim AH, Yoon S, Lee Y, Lee J, Bae E, Lee H, Kim DK, Lee S, Yu KS, Jang IJ, Cho JY

Journal of Korean medical science 2018,Oct;31;33(53):e298.
165

The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs

Park HW, Kim SH, Chang YS, Kim SH, Jee YK, Lee AY, Jang IJ, Park HS, Min KU

Allergy Asthma Immunol Res 2018,Sep;10(5):555-561.
166

Lack of a Clinically Significant Pharmacokinetic Interaction Between Pregabalin and Thioctic Acid in Healthy Volunteers

Rhee SJ, Lee H, Ahn LY, Lim KS, Yu KS

Clinical therapeutics 2018,Sep;40(10):1720-1728.e2.
167

Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity.

Oh J, Yi S, Gu N, Shin D, Yu KS, Yoon SH, Cho JY, Jang IJ

Genomics & informatics. 2018,Sep;16(3):52-58.
168

Regulation of Endogenic Metabolites by Rosuvastatin in Hyperlipidemia Patients: An Integration of Metabolomics and Lipidomics

Lee H, Choi JM, Cho JY, Kim TE, Lee HJ, Jung BH

Chemistry and physics of lipids. 2018,Aug;214:69-83
169

"Ursodeoxycholic acid improves liver function via phenylalanine/ tyrosine pathway and microbiome remodelling in patients with liver dysfunction"

Kim DJ, Yoon S, Ji SC, Yang J, Kim YK, Lee S, Yu KS, Jang IJ, Chung JY, Cho JY

Scientific reports 2018,Aug;8;8(1):11874.
170

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers

Lee S, Kim Y, Lee JJ, SIm G, Cho JY, Chung JY,, Yoon S

European journal of clinical pharmacology 2018,Aug; doi: 10.1007/s00228-018-2543-0. [Epub ahead of print]
171

Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.

Yang EJ, Mahmood U, Kim H, Choi M, Choi Y, Lee JP, Cho JY, Hyun JW, Kim YS, Chang MJ, Kim HS

Free radical biology and medicine 2018,Aug;126:221-234.
172

"HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model"

Tsogbadrakh B, Ju KD, Lee J, Han M, Koh J, Yu Y, Lee H, Yu KS, Oh YK, Kim HJ, Ahn C, Oh KH

PLoS ONE 2018,Aug;30;13(8):e0201692
173

Favorable outcome of post-transplantation cyclophosphamide haploidentical peripheral blood stem cell transplantation with targeted busulfan-based myeloablative conditioning using intensive pharmacokinetic monitoring in pediatric patients.

Hong KT, Kang HJ, Choi JY, Hong CR, Cheon JE, Park JD, Park KD, Song SH, Yu KS, Jang IJ, Shin HY

Biol Blood Marrow Transplant 2018,Jul; pii: S1083-8791(18)30383-5.
174

Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects

Sunwoo J, Oh J, Moon SJ, Ji SC, Lee SH, Yu KS, Kim HS, Lee A, Jang IJ

Aliment. Pharmacol. Ther 2018,Jul;;48(2):206-218.
175

Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers

Yewon Choi, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu

Drug Des Devel Ther 2018,Jul;24;12:2301-2309.
176

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic.

Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY.

Drug Des Devel Ther 2018,Jun;11;12:1707-1714.
177

Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects.

Kim E, Kim A, Yi S, Kim YK, Jang SB, Byun HM, Yoon SH, Cho JY, Jang IJ, Yu KS, Lee S

European journal of clinical pharmacology 2018,Jun;74(10):1261-1272.
178

Identification of ω- or (ω-1)-hydroxylated medium-chain acylcarnitines as novel urinary biomarkers for CYP3A activity.

kim B, Lee J, Shin KH, Lee S, Yu KS, Jang IJ, Cho JY.

Clin Pharmacol Ther 2018,May;2018 May;103(5):879-887. doi: 10.1002/cpt.856. Epub 2017 Oct 10.
179

The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers.

Moschetti V, Kim M, Sand M, Wunderlich G, Andersen G, Feifel U, Jang IJ, Timmer W, Rosenbrock H, Boland K

Eur Neuropsychopharmacol 2018,May;;28(5):643-655.
180

Identification of ω- or (ω-1)-Hydroxylated Medium-Chain Acylcarnitines as Novel Urinary Biomarkers for CYP3A Activity.

Kim B, Lee J, Shin KH, Lee S, Yu KS, Jang IJ, Cho JY.

Clin Pharmacol Ther 2018,May;103(5):879-887.
181

A phase 4 study of nilotinib in Korean patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTKorea

Shin J, Koh Y, Yoon SH, Cho JY, Kim DY, Lee KH, Kim HJ, Ahn JS, Kim YK, Park J, Sohn SK, Moon JH, Lee YJ, Yoon S, Lee JO, Cheong JW, Kim KH, Kim SH, Kim HG, Kim H, Nam SH, Do YR, Park SG, Park SK, Bae SH, Song HH, Shin DY, Oh D, Kim MK, Jung CW, Park S, Kim I

Cancer medicine 2018,May;7(5):1814-1823
182

Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet.

Lee S, Nam KY, Oh J, Lee S, Cho SM, Choi YW, Cho JY, Lee BJ, Hong JH

Drug Des Devel Ther 2018,May;23;12:1413-1420.
183

Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ.

Drug Des Devel Ther 2018,Apr;30;12:1045-1051
184

Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker

Kim AH, Kim B, Rhee SJ, Lee Y, Park JS, Lee SM, Kim SM, Lee S, Yu KS, Jang IJ, Cho JY

Drug metabolism and pharmacokinetics 2018,Apr;33(3):173-178.
185

Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians

Lee J, Rhee SJ, Lee S, Yu KS

Drug Des Devel Ther 2018,Apr;6;12:787-794.
186

The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension.

Suh HJ, Yoon SH, Yu KS, Cho JY, Park SI, Lee E, Lee JO, Koh Y, Song KH, Choe PG, Kim ES, Bang SM, Kim HB, Kim I, Kim NJ, Song SH, Park WB, Oh MD

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2018,Apr; 26;62(7).
187

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH

Drug Des Devel Ther 2018,Apr;20;12:935-942
188

Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram.

Yoon S, Park KR, Lee S, Song SH, Park WB, Jang IJ, Yu KS.

Basic Clin Pharmacol Toxicol 2018,Feb;2018 Feb;122(2):233-238. doi: 10.1111/bcpt.12873. Epub 2017 Sep 6.
189

Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients With Hematologic Malignancies.

"Suh HJ, Kim I, Cho JY, Park SI, Yoon SH, Hwang JH, Bae JY, Lee JO, Koh Y, Song KH, Choe PG, Yu KS, Kim ES, Kim HB, Bang SM, Kim NJ, Song SH, Park WB, Oh MD"

Ther Drug Monit 2018,Feb;;40(1):115-119.
190

Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram.

Yoon S, Park KR, Lee S, Song SH, Park WB, Jang IJ, Yu KS.

Basic Clin Pharmacol Toxicol 2018,Feb;122(2):233-238.
191

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects.

"Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S."

Drug Des Devel Ther 2018,Feb;19;12:331-337.
192

Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study.

Lee S, Hwang JG, Park SY, Lim HJ, Lee SW, Seo MH, Kim J, Hong JH

Advances in therapy 2018,Feb;35(2):210-217.
193

Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study.

Oh J, Lee S, Kim A, Yoon J, Jang K, Lee DH, Cho S, Lee SR, Yu KS, Chung JY

J Clin Pharmacol 2018,Jan;2018 Jan;58(1):64-73. doi: 10.1002/jcph.973. Epub 2017 Aug 16.
194

S-1-Induced Lacrimal Drainage Obstruction and its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-Institutional Study.

Kim N, Kim JW, Baek JH, Kim JS, Choung HK, Kim TY, Lee KH, Bang YJ, Khwarg SI, Ahn SH, Park DJ, Kim HH, Chung JY, Ahn S, Lee KW.

Cancer Res Treat 2018,Jan;2018 Jan;50(1):30-39. doi: 10.4143/crt.2016.569. Epub 2017 Feb 27.
195

Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects.

Choi Y, Lee SW, Kim A, Jang K, Nam H, Cho YL, Yu KS, Jang IJ, Chung JY.

J Antimicrob Chemother 2018,Jan;1;73(1):183-190.
196

A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study.

Chung H, Oh J, Yoon SH, Yu KS, Cho JY, Chung JY

PloS one 2018,Jan;17;13(1):e0191258
197

Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study.

Oh J, Lee S, Kim A, Yoon J, Jang K, Lee DH, Cho S, Lee SR, Yu KS, Chung JY.

J Clin Pharmacol 2018,Jan;;58(1):64-73.
198

S-1-Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study.

"Kim N, Kim JW, Baek JH, Kim JS, Choung HK, Kim TY, Lee KH, Bang YJ, Khwarg SI, Ahn SH, Park DJ, Kim HH, Chung JY, Ahn S, Lee KW."

Cancer Res Treat 2018,Jan;50(1):30-39.
199

Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients with Hematologic Malignancies.

Suh HJ, Kim I, Cho JY, Park SI, Yoon SH, Hwang JH, Bae JY, Lee JO, Koh Y, Song KH, Choe PG, Yu KS, Kim ES, Kim HB, Bang SM, Kim NJ, Oh MD, Song SH, Park WB

Ther Drug Monit 2017,Nov;10.1097/FTD.0000000000000469. [Epub ahead of print]
200

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials.

Kim S,Lee S, Cho JY, Yoon SH, Jang IJ, Yu KS,

Drug Des Devel Ther 2017,Nov;7;11:3187-3195.
201

Performance of the Minto model for the target-controlled infusion of remifentanil during cardiopulmonary bypass.

Cho YJ, Jo WY, Oh H, Koo CH, Oh J, Cho JY, Yu KS, Jeon Y, Kim TK

Anaesthesia 2017,Oct;72(10):1196-1205. doi: 10.1111/anae.14019.
202

Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers.

Yoon S, Rhee SJ, Heo SJ, Oh TY, Yoon SH, Cho JY, Lee S, Yu KS.

Drug Des Devel Ther 2017,Oct;27;11:3127-3135.
203

Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct.

Lee H, Lee H, Baik J, Kim H, Kim R.

Drug Des Devel Ther 2017,Oct;19;11:3035-3043.
204

Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate After Single-dose Administration in Healthy Korean Male Subjects.

Kim Y, Kim A, Lee S, Choi SH, Lee DY, Song JS, Lee H, Jang IJ, Yu KS

Clin Ther 2017,Sep;39(9):1849-1857. doi: 10.1016/j.clinthera.2017.08.002. Epub 2017 Aug 31.
205

New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients.

Kim YK, Kim A, Park SJ, Lee H.

Drug Des Devel Ther 2017,Sep;28;11:2861-2869.
206

Integrative Analysis of Renal Ischemia/Reperfusion Injury and Remote Ischemic Preconditioning in Mice.

Cho K, Min SI, Ahn S, Min SK, Ahn C, Yu KS, Jang IJ, Cho JY, Ha J.

J Proteome Res 2017,Aug;16(8):2877-2886. doi: 10.1021/acs.jproteome.7b00167. Epub 2017 Jul 3.
207

Risk factors for suboptimal drug concentration of posaconazole oral suspension in patients with hematologic malignancy.

Kim EJ, Yu KS, Na SH, Nam EY, Oh HS, Kim M, Yoon SH, Lee JO, Koh Y, Song KH, Choe PG, Cho JY, Song SH, Kim ES, Kim HB, Bang SM, Kim NJ, Oh MD, Kim I, Park WB.

J Mycol Med 2017,Aug;pii: S1156-5233(17)30102-6. doi: 10.1016/j.mycmed.2017.08.001. [Epub ahead of print]
208

Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs.

Joo K, Park SJ, Choi Y, Lee JE,, Na YM, Hong HK, Park KH, Kim HM, Chung JY, Woo SJ

Invest Ophthalmol Vis Sci 2017,Aug;58(10):4261-4267. doi: 10.1167/iovs.17-21813.
209

Correction: GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism.

Na YR, Gu GJ, Jung D, Kim YW, Na J, Woo JS, Cho JY, Youn H, Seok SH.

J Immunol 2017,Aug;198(7):3000. doi: 10.4049/jimmunol.1700174.
210

A novel K+ competitive acid blocker, YH4808, sustains inhibition of gastricacid secretion with a faster onset than esomeprazole: randomised clinicalstudy in healthy volunteers.

Yi S, Lee H, Jang SB, Byun HM, Yoon SH, Cho JY, Jang IJ, Yu KS

Alimentary pharmacology & therapeutics. 2017,Aug;46(3):337-346.
211

The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein.

Kim TE, Shin D, Gu N, Jung BH, Kim J, Cho YM, Yu KS, Cho JY.

Basic Clin Pharmacol Toxicol 2017,Jul;121(3):195-201. doi: 10.1111/bcpt.12826. Epub 2017 Jul 10.
212

LBEC0101, A Proposed Etanercept Biosimilar: Pharmacokinetics, Immunogenicity, and Tolerability Profiles Compared with a Reference Biologic Product in Healthy Male Subjects.

Lee H, Chung H, Lee S, Lee H, Yang SM, Yoon SH, Cho JY, Jang IJ, Yu KS.

BioDrugs 2017,Jul;doi: 10.1007/s40259-017-0230-9. [Epub ahead of print]
213

Pediatric patients undergoing hematopoietic stem cell transplantation can greatly benefit from a novel once-daily intravenous busulfan dosing nomogram.

Rhee SJ, Lee JW, Yu KS, Hong KT, Choi JY, Hong CR, Park KD, Shin HY, Song SH, Kang HJ, Lee H

Am. J. Hematol. 2017,Jul;92(7):607-613. doi: 10.1002/ajh.24734. Epub 2017 May 30.
214

Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea.

Choi YJ, Kim N, Jang IJ, Cho JY, Nam RH, Park JH, Jo HJ, Yoon H, Shin CM, Park YS, Lee DH, Jung HC

Gut Liver 2017,Jul;11(4):504-511. doi: 10.5009/gnl16352.
215

Plasma LTE4/PGF2α Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation.

Ban GY, Ye YM, Kim SH, Hur GY, Kim JH, Shim JJ, Cho K, Cho JY, Park HS; PRANA group.

Allergy Asthma Immunol Res 2017,Jul;9(4):378-382. doi: 10.4168/aair.2017.9.4.378.
216

Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females.

Lee J, Kim AH, Yi S, Lee S, Yoon SH, Yu KS, Jang IJ, Cho JY

AAPS J 2017,Jul;19(4):1196-1204. doi: 10.1208/s12248-017-0090-8. Epub 2017 May 18.
217

Prediction of serum theophylline concentrations and CYP1A2 activity by analyzing urinary metabolites in preterm infants

Sohn JA, Kim HS, Oh J, Cho JY, Yu KS, Lee J, Shin SH, Lee JA, Choi CW, Kim EK, Kim BI, Park EA.

Br J Clin Pharmacol 2017,Jun;83(6):1279-1286. doi: 10.1111/bcp.13211. Epub 2017 Jan 18.
218

Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies.

Suh HJ, Kim I, Cho JY, Park SI, Yoon SH, Lee JO, Koh Y, Song KH, Choe PG, Yu KS, Kim ES, Kim HB, Bang SM, Kim NJ, Song SH, Park WB, Oh MD

Infect Chemother 2017,Jun;49(2):135-139. doi: 10.3947/ic.2017.49.2.135. Epub 2017 Jun 9.
219

A Significant Influence of Metronidazole on Busulfan Pharmacokinetics: A Case Report of Therapeutic Drug Monitoring.

Chung H, Yu KS, Hong KT, Choi JY, Hong CR, Kang HJ, Park KD, Shin HY, Lee S.

Ther Drug Monit 2017,Jun;39(3):208-210. doi: 10.1097/FTD.0000000000000395.
220

High-Fat Diet and Voluntary Chronic Aerobic Exercise Recover Altered Levels of Aging-Related Tryptophan Metabolites along the Kynurenine Pathway.

Lee KJ, Jung KH, Cho JY, Lee ST, Kim HS, Shim JH, Lee SK, Kim M, Chu K

Exp Neurobiol 2017,Jun;26(3):132-140. doi: 10.5607/en.2017.26.3.132. Epub 2017 Jun 26.
221

Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD).

Kim HY, Yoo TH, Hwang Y, Lee GH, Kim B, Jang J, Yu HT, Kim MC, Cho JY, Lee CJ, Kim HC, Park S, Lee WW

Sci Rep 2017,Jun;7(1):3057. doi: 10.1038/s41598-017-03130-z.
222

Pharmacokinetic comparison using two tablets of an evogliptin/metformin XR 2.5/500 mg fixed dose combination vs. 1 tablet each of evogliptin 5 mg and metformin XR 1,000 mg .

Yoon S, Rhee SJ, Park SI, Yoon SH, Cho JY, Jang IJ, Lee S, Yu KS.

Int J Clin Pharmacol Ther 2017,Jun;55(6):533-539. doi: 10.5414/CP202930.
223

Pharmacokinetics and Safety of a Single Dose of the Novel Necrosis Inhibitor LC28-0126 in Healthy Male Subjects

Kim S, Chung H, Lee SH, Cho SH, Cho HJ, Kim SH, Jang IJ, Yu KS.

Br J Clin Pharmacol 2017,Jun;83(6):1205-1215. doi: 10.1111/bcp.13213. Epub 2017 Jan 25.
224

Korean Variant Archive (KOVA): a reference database of genetic variations in the Korean population.

Lee S, Seo J, Park J, Nam JY, Choi A, Ignatius JS, Bjornson RD, Chae JH, Jang IJ, Lee S, Park WY, Baek D, Choi M

Sci Rep 2017,Jun;7(1):4287. doi: 10.1038/s41598-017-04642-4.
225

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Jang K, Kim M, Oh J, Lee S, Cho J, Yu K, Choi T, Lee S, Lim K,

Drug Design, Development and Therapy 2017,May;11:705-711. doi: 10.2147/DDDT.S124307. eCollection 2017.
226

Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients.

Kim B, Lee JW, Hong KT, Yu KS, Jang IJ, Park KD, Shin HY, Ahn HS, Cho JY, Kang HJ.

Sci Rep 2017,May;7(1):1711. doi: 10.1038/s41598-017-01861-7.
227

Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches.

Lee J, Ji SC, Kim B, Yi S, Shin KH, Cho JY, Lim KS, Lee SH, Yoon SH, Chung JY, Yu KS, Park HS, Kim SH, Jang IJ

Clin Transl Sci 2017,May;10(3):163-171. doi: 10.1111/cts.12425. Epub 2016 Oct 26.
228

Characterization of ADME gene variation in 21 populations by exome sequencing.

Hovelson DH, Xue Z, Zawistowski M, Ehm MG, Harris EC, Stocker SL, Gross AS, Jang IJ, Ieiri I, Lee JE, Cardon LR, Chissoe SL, Abecasis G, Nelson MR

Pharmacogenet Genomics 2017,May;27(3):89-100. doi: 10.1097/FPC.0000000000000260.
229

Physiologically Based Pharmacokinetic Modelling and Prediction of Metformin Pharmacokinetics in Renal/Hepatic-Impaired Young Adults and Elderly Populations.

Rhee SJ, Chung H, Yi S, Yu KS, Chung JY.

Eur J Drug Metab Pharmacokinet 2017,May;doi: 10.1007/s13318-017-0418-x. [Epub ahead of print]
230

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects.

Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS

Drug Des Devel Ther 2017,May;11:713-723. doi: 10.2147/DDDT.S126861. eCollection 2017.
231

Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.

Jun SY, Jang IJ, Yoon S, Jang K, Yu KS, Cho JY, Seong MW, Jung GM, Yoon SJ, Kang SH.

Antimicrob Agents Chemother 2017,May;61(6). pii: e02629-16. doi: 10.1128/AAC.02629-16. Print 2017 Jun.
232

Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers.

Park S, Hyun YJ, Kim YR, Lee JH, Ryu S, Kim JM, Oh WY, Na HS, Lee JG, Seo DW, Hwang IY, Park Z, Jang IJ, Oh J, Choi SE

J Korean Med Sci 2017,May;32(5):729-736. doi: 10.3346/jkms.2017.32.5.729.
233

A randomized, double-blind, single-dose, two-arm, parallel study comparing pharmacokinetics, immunogenicity and tolerability of branded adalimumab and its biosimilar LBAL in healthy male volunteers.

Park KR, Chung H, Yang SM, Lee S, Yoon SH, Cho JY, Jang IJ, Yu KS

Expert Opin Investig Drugs 2017,May;26(5):619-624. doi: 10.1080/13543784.2017.1307339. Epub 2017 Mar 23.
234

A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET TM Plus platform

Y Choi, F Jiang, H An, H J Park, J H Choi, H Lee

Pharmacogenomics J . 2017,May;2017 Mar;17(2):174-179.
235

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans.

Oh J, Lee S, Lee H, Cho JY, Yoon SH, Jang IJ, Yu KS, Lim KS

PLoS ONE 2017,Apr;12(4):e0176320. doi: 10.1371/journal.pone.0176320. eCollection 2017.
236

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.

Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N.

Drug Des Devel Ther. 2017,Apr;11:1301-1313. doi: 10.2147/DDDT.S128727. eCollection 2017.
237

Targeted next-generation sequencing for comprehensive genetic profiling of pharmacogenes.

Han SM, Park J, Lee JH, Lee SS, Kim H, Han H, Kim Y, Yi S, Cho JY, Jang IJ, Lee MG

Clin Pharmacol Ther 2017,Mar;101(3):396-405
238

A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects.

Kim YK, Choi MJ, Oh TY, Yu KS, Lee S

Drug Des Devel Ther 2017,Mar;10;11:713-723.
239

Pharmacokinetic comparison and bioequivalence evaluation of two 10-mg baclofen formulations in healthy male subjects .

Yoon S, Lee S, Yu KS, Yim SV, Kim BH.

Int J Clin Pharmacol Ther 2017,Feb;55(2):194-200. doi: 10.5414/CP202760.
240

Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel DPP-IV inhibitor, evogliptin (DA-1229).

Oh J, Kim AH, Lee S, Cho H, Kim YS, Bahng MY, Yoon SH, Cho JY, Jang IJ, Yu KS

Diabetes Obes Metab 2017,Feb;19(2):294-298. doi: 10.1111/dom.12813. Epub 2016 Nov 24.
241

Population pharmacokinetics and dose-response relationship of levetiracetam in adult patients with epilepsy.

Rhee SJ, Shin JW, Lee S, Moon J, Kim TJ, Jung KY, Park KI, Lee ST, Jung KH, Yu KS, Jang IJ, Chu K, Lee SK.

Epilepsy Res. 2017,Feb;132:8-14. doi: 10.1016/j.eplepsyres.2017.02.011. Epub 2017 Feb 27.
242

Changes in Cardiac Function After a Single Intravenous Administration of CKD-712 in Healthy Male Volunteers.

Park SI, Kim J, Yu KS, Jang IJ, Lee S.

Clin Drug Investig 2017,Feb;37(4):393-403. doi: 10.1007/s40261-017-0494-3.
243

An accelerator mass spectrometry-enabled microtracer study to evaluate the first-pass effect on the absorption of YH4808.

Kim A, Yu BY, Dueker SR, Shin KH, Kim HS, Ahn H, Cho JY, Yu KS, Jang IJ, Lee H

Clin Pharmacol Ther 2017,Feb;102(3):537-546. doi: 10.1002/cpt.672. Epub 2017 May 26.
244

Bioequivalence of two formulations of pregabalin 150-mg capsules under fasting conditions in healthy male subjects .

Lee HA, Lee S, Yim SV, Kim BH.

Int J Clin Pharmacol Ther 2017,Feb;55(2):171-176.
245

Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults.

Chung H, Kim A, Lim KS, Park SI, Yu KS, Yoon SH, Cho JY, Chung JY.

Int Clin Psychopharmacol 2017,Jan;32(1):20-26.
246

Pharmacokinetic comparison of two formulations of talniflumate 370 mg tablets in healthy Korean volunteers 

Kim Y, Yim S, Kim BH, Lee S.

Int J Clin Pharmacol Ther 2017,Jan;55(1):102-108. doi: 10.5414/CP202707.
247

Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.

Ban GY, Cho K, Kim SH, Yoon MK, Kim JH, Lee HY, Shin Y, Ye YM, Cho JY, Park HS

Clin. Exp. Allergy 2017,Jan;47(1):37-47.
248

Combined untargeted and targeted metabolomic profiling reveals urinary biomarkers for discriminating obese from normal-weight adolescents.

Cho K, Moon JS, Kang JH, Jang HB, Lee HJ, Park SI, Yu KS, Cho JY.

Pediatr Obes 2017,Jan;12(2):93-101.
249

Pharmacokinetic characteristics of fluticasone, salmeterol and tiotropium after concurrent inhalation

선우정, 이수진, 이승환, 이상원, 정진아, 손한길, 장인진

Translational and Clinical Pharmacology 2017,Jan;2017, vol.25, no.2, pp. 85-92 (8 pages)
250

Comparative pharmacokinetic and bioequivalence evaluation of two formulations of morniflumate 350-mg tablets in healthy male subjects

Heechan Lee, Sung-Vin Yim, Bo-Hyung Kim, SeungHwan Lee

International journal of clinical pharmacology and therapeutics. 2017,Jan;Int J Clin Pharmacol Ther. 2017 Jan;55(1):95-101
251

Determination of the starting dose in the first-in-human clinical trials with monoclonal antibodies: a systematic review of papers published between 1990 and 2013.

Suh HY, Peck CC, Yu KS, Lee H

Drug Des Devel Ther 2016,Dec;10:4005-4016. eCollection 2016.
252

Pharmacokinetics and Safety of a Single Dose of the Novel Necrosis Inhibitor LC28-0126 in Healthy Male Subjects

Kim S, Chung H, Lee SH, Cho SH, Cho HJ, Kim SH, Jang IJ, Yu KS.

Br J Clin Pharmacol 2016,Dec;83(6):1205-1215. doi: 10.1111/bcp.13213. Epub 2017 Jan 25.
253

Prediction of serum theophylline concentrations and CYP1A2 activity by analyzing urinary metabolites in preterm infants

Sohn JA, Kim HS, Oh J, Cho JY, Yu KS, Lee J, Shin SH, Lee JA, Choi CW, Kim EK, Kim BI, Park EA.

Br J Clin Pharmacol 2016,Dec;;83(6):1279-1286. doi: 10.1111/bcp.13211. Epub 2017 Jan 18.
254

Characterization of ADME gene variation in 21 populations by exome sequencing.

Hovelson DH1, Xue Z, Zawistowski M, Ehm MG, Harris EC, Stocker SL, Gross AS, Jang IJ, Ieiri I, Lee JE, Cardon LR, Chissoe SL, Abecasis G, Nelson MR

Pharmacogenet Genomics 2016,Dec;(3):89-100. doi: 10.1097/FPC.0000000000000260.
255

HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption.

Moon J,, Kim TJ, Lim JA, Sunwoo JS, Byun JI, Lee ST, Jung KH, Park KI, Jung KY, Jeon D, Yu KS, Jang IJ, Chu K, Lee SK

Epilepsia. 2016,Nov;57(11):1879-1886. doi: 10.1111/epi.13566. Epub 2016 Sep 26.
256

A bioequivalence study of two omeprazole formulations in healthy male volunteers.

Kim YK, Yoon S, Yu KS, Kim BH, Yim SV.

Int J Clin Pharmacol Ther 2016,Nov;54(11):928-934.
257

Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease.

Ju HY, Kang HJ, Hong CR, Lee JW, Kim H, Song SH, Yu KS, Jang IJ, Park JD, Park KD, Shin HY, Kim JG, Ahn HS

Korean journal of pediatrics. 2016,Nov;6:36599. doi: 10.1038/srep36599.
258

Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease.

Trinh HK, Kim SC, Cho K, Kim SJ, Ban GY, Yoo HJ, Cho JY, Park HS, Kim SH

Sci Rep 2016,Nov;6:36599. doi: 10.1038/srep36599.
259

GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism.

Na YR, Gu GJ, Jung D, Kim YW, Na J, Woo JS, Cho JY, Youn H, Seok SH

Journal of immunology 2016,Nov;197(10):4101-4109. Epub 2016 Oct 14.
260

The pharmacokinetic comparison and bioequivalence evaluation of two 10-mg baclofen formulations in healthy male subjects .

Yoon S, Lee S, Yu KS, Yim SV, Kim BH.

Int J Clin Pharmacol Ther 2016,Nov;55(2):194-200. doi: 10.5414/CP202760.
261

Targeted next-generation sequencing for comprehensive genetic profiling of pharmacogenes.

Han SM, Park J, Lee JH, Lee SS, Kim H, Han H, Kim Y, Yi S, Cho JY, Jang IJ, Lee MG

Clin Pharmacol Ther 2016,Oct;101(3):396-405. doi: 10.1002/cpt.532. Epub 2016 Nov 24.
262

Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches.

Lee J, Ji SC, Kim B, Yi S, Shin KH, Cho JY, Lim KS, Lee SH, Yoon SH, Chung JY, Yu KS, Park HS, Kim SH, Jang IJ

Clin Transl Sci 2016,Oct;10(3):163-171. doi: 10.1111/cts.12425. Epub 2016 Oct 26.
263

Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults.

Chung H, Kim A, Lim KS, Park SI, Yu KS, Yoon SH, Cho JY, Chung JY.

Int Clin Psychopharmacol 2016,Oct;32(1):20-26.
264

Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates WithMidazolam Clearance Under Hepatic CYP3A Inhibition and Inductionin Females: A Pharmacometabolomics Approach

Kwang-Hee Shin, Li Young Ahn, Man Ho Choi, Ju-Yeon Moon, Jieon Lee, In-Jin Jang, Kyung-Sang Yu, Joo-Youn Cho

The AAPS Journal 2016,Sep;1254-61. doi: 10.1208/s12248-016-9941-y. Epub 2016 Jun 17.
265

Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study.

Choi Y, Lee S, Cho SM, Kang WH, Nam KY, Jang IJ, Yu KS

Drug Des Devel Ther 2016,Sep;10:3021-3028. eCollection 2016.
266

Pharmacokinetics, Safety, and Tolerability of Metformin in Healthy Elderly Subjects.

Jang K, Chung H, Yoon JS, Moon SJ, Yoon SH, Yu KS, Kim K, Chung JY

J Clin Pharmacol 2016,Sep;56(9):1104-10. doi: 10.1002/jcph.699. Epub 2016 Feb 22.
267

Comparison of R(+)-α-lipoic acid exposure after R(+)-α-lipoic acid 200 mg and 300 mg and thioctic acid 600 mg in healthy Korean male subjects

윤장수, 문설주, 이광옥, 윤서현, 장인진, 유경상, 이승환

TCP 2016,Sep;24(3):137-142
268

Therapeutic drug monitoring of vancomycin in a patient with Duchenne muscular dystrophy (DMD): A case report

이상원, 윤성혜, 유경상, 이승환

TCP 2016,Sep;24(3):124-126
269

Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment.

Kim A, Lee J, Shin D, Jung YJ, Bahng MY, Cho JY, Jang IJ

Br J Clin Pharmacol 2016,Aug;82(2):389-98. doi: 10.1111/bcp.12977. Epub 2016 Jun 3.
270

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects.

Rhee SJ, Choi Y, Lee S, Oh J, Kim SJ, Yoon SH, Cho JY, Yu KS

Drug Des Devel Ther 2016,Aug;10:2525-34. doi: 10.2147/DDDT.S110712. eCollection 2016.
271

An analysis of QTc prolongation with atypical antipsychotic medications and selective serotonin reuptake inhibitors using a large ECG record database.

Park SI, An H, Kim A, Jang IJ, Yu KS, Chung JY.

Expert Opin Drug Saf 2016,Aug;15(8):1013-9. doi: 10.1080/14740338.2016.1199681. Epub 2016 Jun 22.
272

Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.

Ban GY, Cho K, Kim SH, Yoon MK, Kim JH, Lee HY, Shin Y, Ye YM, Cho JY, Park HS

Clin. Exp. Allergy 2016,Aug;47(1):37-47. doi: 10.1111/cea.12797. Epub 2016 Sep 27.
273

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs.

Ahn SJ, Hong HK, Na YM, Park SJ, Ahn J, Oh J, Chung JY, Park KH, Woo SJ

Journal of visualized experiments 2016,Jul;(113). doi: 10.3791/53878.
274

Effectiveness of increasing the frequency of posaconazole syrup administration to achieve optimal plasma concentrations in patients with haematological malignancy.

cho K, Moon JS, Kang JH, Jang HB, Lee HJ, Park SI, Yu KS, Cho JY.

Int J Antimicrob Agents 2016,Jul;48(1):106-10. doi: 10.1016/j.ijantimicag.2016.04.013. Epub 2016 May 12.
275

Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians.

Hasunuma T, Tohkin M, Kaniwa N, Jang IJ, Yimin C, Kaneko M, Saito Y, Takeuchi M, Watanabe H,Yamazoe Y, Uyama Y, Kawai

Br J Clin Pharmacol 2016,Jun;81(6):1078-90. doi: 10.1111/bcp.12884. Epub 2016 Mar 14.
276

A thorough QT study to evaluate the QTc prolongation potential of two neuropsychiatric drugs, quetiapine and escitalopram, in healthy volunteers

Kim A, Lim KS, Lee H, Chung H, Yoon SH, Yu KS, Cho JY, Jang IJ, Chung JY.

Int Clin Psychopharmacol 2016,Jun;31(4):210-7. doi: 10.1097/YIC.0000000000000124.
277

Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers

이지언, 김언혜, 유경상, 정재용, 임성빈, 김보형

TCP 2016,Jun;24(2):111
278

Pharmacokinetic comparison of two levofloxacin 100-mg tablet formulations and determination of time point appropriately reflecting its area under the curve

박경윤, 장경호, 이승환, 유경상, 김보형, 임성빈

TCP 2016,Jun;24(2):84-89
279

Evaluation of factors associated with drug-induced liver injury using electronic medical records

정혜원, 안형미, 이지은, 오재성, 유경상, 정재용

TCP 2016,Jun;24(2):78-83
280

Intraocular Pharmacokinetics of Intravitreal Aflibercept (Eylea) in a Rabbit Model.

Park SJ, Choi Y, Na YM, Hong HK, Park JY, Park KH, Chung JY, Woo SJ

Invest Ophthalmol Vis Sci 2016,May;1;57(6):2612-7. doi: 10.1167/iovs.16-19204.
281

Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.

Bae EK, Lee J, Shin JW, Moon J, Lee KJ, Shin YW, Kim TJ, Shin D, Jang IJ, Lee SK

Seizure 2016,Apr;37:8-12. doi: 10.1016/j.seizure.2016.02.002. Epub 2016 Feb 11.
282

Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function

"Seung Seok Han, Seung Hee Yang, Min Chang Kim, Joo-Youn Cho, Sang-Il Min, Jung Pyo Lee, Dong Ki Kim

PLoS One 2016,Apr;11(4):e0153491. doi: 10.1371/journal.pone.0153491. eCollection 2016.
283

The MATE1 rs2289669 polymorphism affects the renal clearance of metformin following ranitidine treatment.

Cho SK, Chung JY.

Cho SK, Chung JY. 2016,Apr;54(4):253-62. doi: 10.5414/CP202473.
284

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan

Namyi Gu, Joo-Youn Cho Kwang-Hee Shin, In-Jin Jang, Moo-Yong Rhee

Drug Des Devel Ther 2016,Apr;10:1525-31. doi: 10.2147/DDDT.S94694. eCollection 2016.
285

Pharmacokinetics of the evogliptin/metformin extended-release (5/1,000 mg) fixed-dose combination formulation compared to the corresponding loose combination, and food effect in healthy subjects

Su-jin Rhee, SeungHwan Lee, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang Kyung-Sang Yu

Drug Des Devel Ther 2016,Apr;10:1411-8. doi: 10.2147/DDDT.S102459. eCollection 2016.
286

Validation of the Korean coefficient for the modification of diet in renal disease study equation.

Oh YJ, Cha RH, Lee SH, Yu KS, Kim SE, Kim H, Kim YS.

Korean J Intern Med 2016,Mar;31(2):344-56. doi: 10.3904/kjim.2015.227. Epub 2016 Jan 13.
287

Phase I Study of CKD-516, a Novel Vascular Disrupting Agent, in Patients with Advanced Solid Tumors.

Oh DY, Kim TM, Han SW, Shin DY, Lee YG, Lee KW, Kim JH, Kim TY, Jang IJ, Lee JS, Bang YJ

Cancer Res Treat. 2016,Jan;48(1):28-36. doi: 10.4143/crt.2014.258. Epub 2015 Feb 23.
288

Inhibition of the MATE transporter by pyrimethamine increases the plasma concentration of metformin but does not increase anti-hyperglycaemic activity in humans.

Oh J, Chung H, Park SI, Yi S, Jang K, Kim A, Yoon J, Cho JY, Yoon SH, Jang IJ, Yu KS, Chung JY.

Diabetes Obes Metab 2016,Jan;18(1):104-108 . doi: 10.1111/dom.12577. Epub 2015 Oct 26.
289

Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel DPP-IV inhibitor, evogliptin (DA-1229).

Oh J, Kim AH, Lee S, Cho H, Kim YS, Bahng MY, Yoon SH, Cho JY, Jang IJ, Yu KS

Diabetes Obes Metab 2016,Jan;19(2):294-298. doi: 10.1111/dom.12813. Epub 2016 Nov 24.
290

Combined untargeted and targeted metabolomic profiling reveals urinary biomarkers for discriminating obese from normal-weight adolescents.

Cho K, Moon JS, Kang JH, Jang HB, Lee HJ, Park SI, Yu KS, Cho JY.

Pediatr Obes 2016,Jan;12(2):93-101. doi: 10.1111/ijpo.12114. Epub 2016 Feb 22.
291

Reliable prediction of anti-diabetic drug failure using a reject option

Seokho Kang, Sungzoon Cho ,Su-jin Rhee ,Kyung-Sang Yu

Pattern Analysis and Applications 2016,Jan; Volume 20, Issue 3, pp 883–891
292

Impact of area under the concentration-time curve to minimum inhibitory concentration ratio on vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus bacteraemia

Song KH, Kim HB, Kim HS, Lee MJ, Jung Y, Kim G, Hwang JH, Kim NH, Kim M, Kim CJ, Choe PG, Chung JY, Park WB, Kim ES, Park KU, Kim NJ, Kim EC, Oh MD.

Int J Antimicrob Agents. 2015,Dec;46(6):689-95. doi: 10.1016/j.ijantimicag.2015.09.010. Epub 2015 Oct 17.
293

Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1

Cho SK, Kim S, Chung JY, Jee SH.

BMJ Open. 2015,Nov;5(11):e009360. doi: 10.1136/bmjopen-2015-009360.
294

The Clinical Significance of Voriconazole Therapeutic Drug Monitoring in Children With Invasive Fungal Infections

Kang HM, Lee HJ, Cho EY, Yu KS, Lee H, Lee JW, Kang HJ, Park KD, Shin HY, Choi EH.

Pediatr Hematol Oncol. 2015,Nov;32(8):557-67. doi: 10.3109/08880018.2015.1088905. Epub 2015 Nov 11.
295

Erratum to: Is Extrapolation of the Safety and Efficacy Data in One Indication to Another Appropriate for Biosimilars?

Lee H.

AAPS J. 2015,Nov;17(6):1520-1. doi: 10.1208/s12248-015-9813-x.
296

Erratum to: Is Extrapolation of the Safety and Efficacy Data in One Indication to Another Appropriate for Biosimilars?

Howard Lee

AAPS J . 2015,Nov;2015 Nov;17(6):1520-1. doi: 10.1208/s12248-015-9813-x.
297

Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form

Seo HJ, Nam SH, Im HJ, Park JY, Lee JY, Yoo B, Lee YS, Jeong JM, Hyeon T, Kim JW,Lee JS, Jang IJ, Cho JY, Hwang do W, Suh YD, Lee DS.

Sci Rep. 2015,Oct;5:15685. doi: 10.1038/srep15685.
298

The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population

Moon J, Park HK, Chu K, Sunwoo JS, Byun JI, Lim JA, Kim TJ, Shin JW, Lee ST, Jung KH, Jung KY, Jeon D, Kim DW, Yu KS, Jang IJ, Kang HR, Park HW, Lee SK.

Epilepsia. 2015,Oct;56(10):e161-7. doi: 10.1111/epi.13087. Epub 2015 Aug 17.
299

GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy

Jang HW, Kim SW, Cho YJ, Heo K, Lee BI, Lee SK, Jang IJ, Lee MG, Kim WJ, Lee JH.

Epilepsy Res. 2015,Sep;115:88-94. doi: 10.1016/j.eplepsyres.2015.05.014. Epub 2015 Jun 2.
300

Validated LC-MS/MS Assay for the Quantitative Determination of Fimasartan in Human Plasma: Application to Pharmacokinetic Studies

Yoon SH, Oh S, Kim HS, Yi S, Yu KS, Jang IJ, Cho JY.

J Chromatogr Sci. 2015,Sep;53(8):1250-6. doi: 10.1093/chromsci/bmu219. Epub 2015 Jan 22.
301

Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects

Yoon S, Shin D, Lee H, Jang IJ, Yu KS.

Drug Des Devel Ther. 2015,Aug;9:5033-49. doi: 10.2147/DDDT.S86884. eCollection 2015.
302

Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers

Park SI, Oh J, Jang K, Yoon J, Moon SJ, Park JS, Lee JH, Song J, Jang IJ, Yu KS, Chung JY.

Antimicrob Agents Chemother. 2015,Aug;59(8):4429-35. doi: 10.1128/AAC.00354-15. Epub 2015 May 18.
303

Phase I/II Study of Weekly Oraxol for the Second-Line Treatment of Patients With Metastatic or Recurrent Gastric Cancer

Lee KW, Lee KH, Zang DY, Park YI, Shin DB, Kim JW, Im SA, Koh SA, Yu KS, Cho JY, Jung JA,Bang YJ.

Oncologist. 2015,Aug;20(8):896-7. doi: 10.1634/theoncologist.2015-0202. Epub 2015 Jun 25.
304

Comparison of the pharmacokinetics and tolerability of HCP1004 (a fixed-dose combination of naproxen and esomeprazole strontium) and VIMOVO? (a marketed fixed-dose combination of naproxen and esomeprazole magnesium) in healthy volunteers

Choi Y, Han H, Shin D, Lim KS, Yu KS.

Drug Des Devel Ther. 2015,Jul;9:4127-35. doi: 10.2147/DDDT.S86725. eCollection 2015.
305

그래프 모델과 중심성 분석을 이용한 당뇨환자의 처방 및 검사결과의 상관관계 분석

유강민, 박성찬, 이수진, 유경상, 이상구.

정보과학회 컴퓨팅의 실제 논문지 제21권 제7호 2015,Jul;482-487 영문 : Analysis on Correlation between Prescriptions and Test Results of Diabetes Patients using Graph Models and Node Centrality.
306

Efficacy, Safety, and Pharmacokinetics of Beroctocog Alfa in Patients Previously Treated for Hemophilia A

Hyun SY, Park SY, Lee SY, Kook H, Paik SH, Jang IJ, Lee KS.

Yonsei Med J. 2015,Jul;56(4):935-43. doi: 10.3349/ymj.2015.56.4.935.
307

Successful empirical antifungal therapy of intravenous itraconazole with pharmacokinetic evidence in pediatric cancer patients undergoing hematopoietic stem cell transplantation

Kim H, Shin D, Kang HJ, Yu KS, Lee JW, Kim SJ, Kim MS, Song ES, Jang MK, Park JD, Jang IJ, Park KD,Shin HY, Ahn HS.

Clin Drug Investig. 2015,Jul;35(7):437-46. doi: 10.1007/s40261-015-0297-3.
308

Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers

Lee JE, Kim AH, Yu KS, Chung JY, Yim SV, Kim BH

TCP. 2015,Jun;23(2):49-53.
309

Bioequivalence study of Donepezil hydrochloride in healthy Korean volunteers

Choi YW, Rhee SJ, Jang IJ, Yu KS, Yim SV, Kim BH.

TCP. 2015,Jun;23(1):26-30.
310

Bioequivalence of the pharmacokinetics between two formulations of 0.2 mg tamsulosin hydrochloride in healthy subjects

Park SI, Rhee SJ, Jang IJ, Yu KS, Yim SV, Kim BH.

TCP. 2015,Jun;23(1):21-25.
311

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

Chung H, Lee H, Han HK, An H, Lim KS, Lee YJ, Cho JY, Yoon SH, Jang IJ, Yu KS.

Drug Des Devel Ther. 2015,May;9:2609-16. doi: 10.2147/DDDT.S80066. eCollection 2015.
312

Intraocular pharmacokinetics of intravitreal vascular endothelial growth factor-Trap in a rabbit model

Park SJ, Oh J, Kim YK, Park JH, Park JY, Hong HK, Park KH, Lee JE, Kim HM, Chung JY, Woo SJ.

Eye (Lond). 2015,Apr;29(4):561-8. doi: 10.1038/eye.2014.329. Epub 2015 Jan 16.
313

Response to "Induction of BOTH P-glycoprotein AND SPECIFIC cytochrome P450 BY aspirin eventually does NOT ALTER the antithrombotic effect of clopidogrel"

Oh J, Ji SC, Lee H, Yu KS, Jang IJ.

Clin Pharmacol Ther. 2015,Apr;97(4):325. doi: 10.1002/cpt.74. Epub 2015 Feb 11.
314

Pharmacokinetic properties and tolerability of rotigotine transdermal patch after repeated-dose application in healthy korean volunteers

Kim BH, Yu KS, Jang IJ, Soo Lim K, Kim JR, Elshoff JP, Andreas JO, Braun M, Cawello W.

Clin Ther. 2015,Apr;37(4):902-12. doi: 10.1016/j.clinthera.2015.01.013. Epub 2015 Mar 16.
315

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects

Park SI, Lee H, Oh J, Lim KS, Jang IJ, Kim JA, Jung JH, Yu KS.

Drug Des Devel Ther. 2015,Feb;9:729-36. doi: 10.2147/DDDT.S75980. eCollection 2015.
316

Limited sampling strategy of partial area under the concentration-time curves to estimate midazolam systemic clearance for cytochrome P450 3A phenotyping

Masters JC, Harano DM, Greenberg HE, Tsunoda SM, Jang IJ, Ma JD.

Ther Drug Monit. 2015,Feb;37(1):84-9. doi: 10.1097/FTD.0000000000000116.
317

Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

Hong T, Han S, Lee J, Jeon S, Park GJ, Park WS, Lim KS, Chung JY, Yu KS, Yim DS.

Drug Des Devel Ther. 2015,Feb;9:1233-45. doi: 10.2147/DDDT.S79772. eCollection 2015.
318

ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy

Kim HJ, Im SA, Keam B, Ham HS, Lee KH, Kim TY, Kim YJ, Oh DY, Kim JH, Han W, Jang IJ, Kim TY, Park IA, Noh DY.

Cancer Sci. 2015,Jan;106(1):86-93. doi: 10.1111/cas.12560. Epub 2014 Dec 8.
319

Favorable outcome of hematopoietic stem cell transplantation using a targeted once-daily intravenous busulfan-fludarabine-etoposide regimen in pediatric and infant acute lymphoblastic leukemia patients

Lee JW, Kang HJ, Kim S, Lee SH, Yu KS, Kim NH, Jang MK, Kim H, Song SH, Park JD, Park KD, Shin HY, Jang IJ, Ahn HS.

Biol Blood Marrow Transplant. 2015,Jan;21(1):190-5. doi: 10.1016/j.bbmt.2014.09.013. Epub 2014 Sep 22.
320

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway

Cho K, Chung JY, Cho SK, Shin HW, Jang IJ, Park JW, Yu KS, Cho JY

Sci Rep. 2015,Jan;5:8145. doi: 10.1038/srep08145.
321

An efficient and effective ensemble of support vector machines for anti-diabetic drug failure prediction.

Kang, S. , Kang, P. , Ko, T. , Cho, S. , Rhee, S.j. , Yu, K.S.

Expert Systems with Applications 2015,Jan;4265-4273
322

A bioequivalence study of two levofloxacin tablets in healthy male subjects

Chung I, Yoon S, Yi S, Kim BH, Yim SV, Jang IJ, Lee H.

Transl Clin Pharmacol 2014,Dec;22(2):102-105.
323

Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers.

Cho SK, Kim CO, Park ES, Chung JY.

Br J Clin Pharmacol 2014,Dec;78(6):1426-32. doi: 10.1111/bcp.12476.
324

Evaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers.

Lee J, Lee H, Jang K, Lim KS, Shin D, Yu KS.

Drug Des Devel Ther 2014,Oct;8:1781-8. doi: 10.2147/DDDT.S68574. eCollection 2014.
325

Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers.

Gu N, Park MK, Kim TE, Bahng MY, Lim KS, Cho SH, Yoon SH, Cho JY, Jang IJ, Yu KS.

Drug Des Devel Ther 2014,Oct;8:1709-21. doi: 10.2147/DDDT.S65678. eCollection 2014.
326

Effect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study.

Kim S, Lee J, Shin D, Lim KS, Kim YS, Jang IJ, Yu KS.

Drug Des Devel Ther 2014,Oct;8:1723-31. doi: 10.2147/DDDT.S68784. eCollection 2014.
327

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: a DMET Plus microarray assessment.

Yi S, An H, Lee H, Lee S, Ieiri I, Lee Y, Cho JY, Hirota T, Fukae M, Yoshida K, Nagatsuka S, Kimura M, Irie S, Sugiyama Y, Shin DW, Lim KS, Chung JY, Yu KS, Jang IJ.

Pharmacogenet Genomics 2014,Oct;24(10):477-85. doi: 10.1097/FPC.0000000000000075.
328

Trough concentration over 12.1 mg/L is a major risk factor of vancomycin-related nephrotoxicity in patients with therapeutic drug monitoring.

Han H, An H, Shin KH, Shin D, Lee S, Kim JH, Cho SH, Kang HR, Jang IJ, Yu KS, Lim KS.

Ther Drug Monit 2014,Oct;36(5):606-11. doi: 10.1097/FTD.0000000000000061.
329

Pharmacokinetic-Pharmacodynamic Relationships of Macitentan, a New Endothelin Receptor Antagonist, After Multiple Dosing in Healthy Korean Subjects.

Ahn LY, Kim SE, Yi S, Dingemanse J, Lim KS, Jang IJ, Yu KS.

Am J Cardiovasc Drugs 2014,Oct;14(5):377-85. doi: 10.1007/s40256-014-0081-4.
330

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects.

Cha YJ, Lim KS, Park MK, Schneider S, Bray B, Kang MC, Chung JY, Yoon SH, Cho JY, Yu KS.

Drug Des Devel Ther 2014,Sep;8:1613-9. doi: 10.2147/DDDT.S65596. eCollection 2014.
331

노인의 임상시험 참여에 대한 현황과 향후 발전 방향 : 임상시험 전문가를 대상으로 한 설문조사 분석

김선욱, 정희원, 박미란, 정재용, 이근욱, 김지현, 이종석, 김광일, 김철호.

J Korean Geriatr Soc 2014,Sep;18(3):122-135.
332

Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers.

Kim TE, Lee H, Lim KS, Lee S, Yoon SH, Park KM, Han H, Shin SG, Jang IJ, Yu KS, Cho JY.

Br J Clin Pharmacol 2014,Sep;78(3):556-64. doi: 10.1111/bcp.12368.
333

Predictive performance of gentamicin dosing nomograms.

Lee J, Yoon S, Shin D, Han H, An H, Lee J, Lim KS, Yu KS, Lee H.

Drug Des Devel Ther 2014,Aug;8:1097-106. doi: 10.2147/DDDT.S66981. eCollection 2014.
334

Investigation of bioequivalence of a new fixed-dose combination of acarbose and metformin with the corresponding loose combination as well as the drug-drug interaction potential between both drugs in healthy adult male subjects.

Kim S, Jang IJ, Shin D, Shin DS, Yoon S, Lim KS, Yu KS, Li J, Zhang H, Liu Y, Brendel E, Blode H, Wang Y.

J Clin Pharm Ther 2014,Aug;39(4):424-31. doi: 10.1111/jcpt.12166. Epub 2014 May 8.
335

An assessment of the pharmacokinetics, pharmacodynamics, and tolerability of GCPGC, a novel pegylated granulocyte colony-stimulating factor (G-CSF), in healthy subjects.

Shin KH, Lim KS, Lee H, Jang IJ, Yu KS.

Invest New Drugs 2014,Aug;32(4):636-43. doi: 10.1007/s10637-014-0068-7. Epub 2014 Jan 28.
336

A Phase I Study of Oral Paclitaxel with a Novel P-Glycoprotein Inhibitor, HM30181A, in Patients with Advanced Solid Cancer.

Lee HJ, Heo DS, Cho JY, Han SW, Chang HJ, Yi HG, Kim TE, Lee SH, Oh DY, Im SA, Jang IJ, Bang YJ.

Cancer Res Treat 2014,Jul;46(3):234-42. doi: 10.4143/crt.2014.46.3.234. Epub 2014 Jul 15.
337

Tolerability and Pharmacokinetics of Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor-γ Agonist, After a Single Oral Administration in Healthy Female Subjects.

Park MK, Kim TE, Kim J, Kim C, Yoon SH, Cho JY, Jang IJ, Yu KS, Lim KS.

Clin Drug Investig 2014,Jul;34(7):467-74. doi: 10.1007/s40261-014-0197-y.
338

Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics.

Kim A, Chung I, Yoon SH, Yu KS, Lim KS, Cho JY, Lee H, Jang IJ, Chung JY.

Drug Metab Dispos 2014,Jul;42(7):1174-9. doi: 10.1124/dmd.113.055616. Epub 2014 Apr 24.
339

A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.

Ahn G, Park DM, Park JW, Kim HY, Cho JY, Rhee SJ, Jang IJ, Kim HK.

Biomed Chromatogr 2014,Jul;28(7):919-22. doi: 10.1002/bmc.3134. Epub 2014 Jan 23.
340

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state.

Jang K, Yoon S, Kim SE, Cho JY, Yoon SH, Lim KS, Yu KS, Jang IJ, Lee H.

Drug Des Devel Ther 2014,Jun;8:851-8. doi: 10.2147/DDDT.S62176. eCollection 2014.
341

Genetic Polymorphisms of the Carboxylesterase 1 (CES1)Gene in a Korean Population.

Cha YJ, Jeong HE, Shin JG, Kim EY, Yu KS, Cho JY, Yoon SH, Lim KS.

Transl Clin Pharmacol 2014,Jun;22(1):30-34.
342

Pregnane X Receptor agonist Increases the __EXPRESSION__ Levels of the Plasma Membrane Monoamine Transporter.

Cho SK, Oh H, Hong SH, Park MS, Chung JY.

Transl Clin Pharmacol 2014,Jun;22(1):19-21.
343

The Effects of Moxifloxacin on QTc Interval in Healthy Korean Male Subjects.

Moon SJ, Lee J, An H, Yim DS, Chung JY, Yu KS, Cho JY, Lim KS.

Drugs R D 2014,Jun;14(2):63-71. doi: 10.1007/s40268-014-0040-1.
344

Aspirin decreases systemic exposure to clopidogrel through modulation of p-glycoprotein but does not alter its antithrombotic activity.

Oh J, Shin D, Lim KS, Lee S, Jung KH, Chu K, Hong KS, Shin KH, Cho JY, Yoon SH, Ji SC, Yu KS, Lee H, Jang IJ.

Clin Pharmacol Ther 2014,Jun;95(6):608-16. doi: 10.1038/clpt.2014.49. Epub 2014 Feb 24.
345

Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects.

Shin D, Cho YM, Lee S, Lim KS, Kim JA, Ahn JY, Cho JY, Lee H, Jang IJ, Yu KS.

Clin Drug Investig 2014,Jun;34(6):383-93. doi: 10.1007/s40261-014-0184-3.
346

Pharmacodynamics, Pharmacokinetics, and Tolerability of Intravenous or Subcutaneous GC1113, a Novel Erythropoiesis-Stimulating Agent.

Han H, Lee J, Shin D, Shin KH, Jeon H, Lim KS, Yoon SH, Shin SG, Jang IJ, Cho JY, Yu KS.

Clin Drug Investig 2014,Jun;34(6):373-82. doi: 10.1007/s40261-014-0183-4.
347

Effect of preservation conditions on cartilage tissue for cell transplantation.

Kim BY, Nam BM, Lee KM, Jo YH, Nemeno JG, Yang W, Lee S, Kim H, Jang IJ, Takebe T, Lee JI.

Transplant Proc 2014,May;46(4):1139-44. doi: 10.1016/j.transproceed.2013.11.125.
348

Voriconazole Therapeutic Drug Monitoring is Necessary for Children with Invasive Fungal Infection.

Kang HM, Kang SY, Cho EY, Yu KS, Lee JW, Kang HJ, Park KD, Shin HY, Ahn HS, Lee H, Choi EH, Lee HJ.

Korean J Pediatr Infect Dis 2014,Apr;21(1):9-21.
349

Seasonal variation in hemoglobin a1c in korean patients with type 2 diabetes mellitus.

Kim YJ, Park S, Yi W, Yu KS, Kim TH, Oh TJ, Choi J, Cho YM.

J Korean Med Sci 2014,Apr;29(4):550-5. doi: 10.3346/jkms.2014.29.4.550. Epub 2014 Apr 1.
350

Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug.

Kim DK, Lee JW, Shin KH, Kim S, Oh KH, Kim M, Yu KS, Lee JP, Lim CS, Kim YS, Joo KW.

BMC Nephrol 2014,Mar;15:46. doi: 10.1186/1471-2369-15-46.
351

Area under the concentration-time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia

Jung Y, Song KH, Cho JE, Kim HS, Kim NH, Kim TS, Choe PG, Chung JY, Park WB, Bang JH, Kim ES, Park KU, Park SW, Kim HB, Kim NJ, Oh MD.

Int J Antimicrob Agents 2014,Feb;43(2):179-83. doi: 10.1016/j.ijantimicag.2013.10.017. Epub 2013 Nov 18.
352

Area under the concentration-time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia.

Jung Y, Song KH, Cho Je, Kim HS, Kim NH, Kim TS, Choe PG, Chung JY, Park WB, Bang JH, Kim ES, Park KU, Park SW, Kim HB, Kim NJ, Oh MD.

Int J Antimicrob Agents 2014,Feb;43(2):179-83. doi: 10.1016/j.ijantimicag.2013.10.017. Epub 2013 Nov 18.
353

Investigating the different mechanisms of genotoxic and non-genotoxic carcinogens by a gene set analysis.

Lee WJ, Kim SC, Lee SJ, Lee J, Park JH, Yu KS, Lim J, Kwon SW.

PLoS One 2014,Jan;9(1):e86700. doi: 10.1371/journal.pone.0086700. eCollection 2014.
354

Intraocular pharmacokinetics of ranibizumab in vitrectomized versus nonvitrectomized eyes.

Ahn SJ, Ahn J, Park S, Kim H, Hwang DJ, Park JH, Park JY, Chung JY, Park KH, Woo SJ.

Invest Ophthalmol Vis Sci 2014,Jan;55(1):567-73. doi: 10.1167/iovs.13-13054.
355

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers.

Yoon S, Lee H, Kim TE, Lee S, Chee DH, Cho JY, Yu KS, Jang IJ.

Drug Des Devel Ther 2014,Jan;8:123-8. doi: 10.2147/DDDT.S53027. eCollection 2014.
356

Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasma

Choi JM, Kim TE, Cho JY, Lee HJ, Jung BH.

J Chromatogr B Analyt Technol Biomed Life Sci 2014,Jan;944:157-65. doi: 10.1016/j.jchromb.2013.10.029. Epub 2013 Oct 26.
357

Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system.

Park YS, Cho JY, Lee SJ, Hwang CI.

Biomed Res Int 2014,Jan;801358. doi: 10.1155/2014/801358. Epub 2014 Jul 22.
358

Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasma.

Choi JM, Kim TE, Cho JY, Lee HJ, Jung BH.

J Chromatogr B Analyt Technol Biomed Life Sci 2014,Jan;944:157-65. doi: 10.1016/j.jchromb.2013.10.029. Epub 2013 Oct 26.
359

Pharmacokinetics, Safety and Tolerability of DA-6034, an Anti-Inflammatory Agent, After Single and Multiple Oral Administrations in Healthy Volunteers.

Lee J, Shin KH, Kim JR, Lim KS, Jang IJ, Chung JY.

Clin Drug Investig 2014,Jan;34(1):37-42. doi: 10.1007/s40261-013-0147-0.
360

Quantification of human plasma-busulfan concentration by liquid chromatography-tandem mass spectrometry.

Moon SY, Lim MK, Hong S, Jeon Y, Han M, Song SH, Lim KS, Yu KS, Jang IJ, Lee JW, Kang HJ, Song J.

Ann Lab Med 2014,Jan;34(1):7-14. doi: 10.3343/alm.2014.34.1.7. Epub 2013 Dec 6.
361

Is extrapolation of the safety and efficacy data in one indication to another appropriate for biosimilars?

Lee H.

AAPS J 2014,Jan;16(1):22-6. doi: 10.1208/s12248-013-9534-y. Epub 2013 Oct 11.
362

Pharmacokinetic Properties and Effects of PT302 After Repeated Oral Glucose Loading Tests in a Dose-Escalating Study.

Gu N, Cho SH, Kim J, Shin D, Seol E, Lee H, Lim KS, Shin SG, Jang IJ, Yu KS.

Clin Ther 2014,Jan;36(1):101-14. doi: 10.1016/j.clinthera.2013.12.002. Epub 2013 Dec 27.
363

건강한 한국인 자원자에서 T-614의 단회 경구 투여 후 약동학적 특성에 대한 연구

신동성, 김보형, 김정렬, 임경수, 장인진, 신상구, 유경상.

대한임상약리학회지 2013,Dec;21(2):150-158
364

건강한 자원자에서 JES9501 단회 및 반복 경구투여 후 안전성 및 약동

김언혜, 김보형, 신동성, 조주연, 유경상, 장인진, 정재용.

대한임상약리학회지 2013,Dec;21(2):141-149
365

건강한 한국인 피험자에서 염산세프카펜 피복실 단회 경구투여 시 약동학적 특성에 관한 연구

이수진, 신광희, 차유정, 김정렬, 오달석, 조주연, 유경상, 장인진, 정재용, 임경수.

대한임상약리학회지 2013,Dec;21(2):104-112
366

Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma

Ahn G, Park DM, Park JW, Cho JY, Rhee SJ, Kim HY, Lee DS, Jang IJ, Kim HK.

Anal Bioanal Chem 2013,Dec;405(30):9817-24. doi: 10.1007/s00216-013-7411-2. Epub 2013 Oct 15.
367

Relationship between absolute neutrophil count profiles and pharmacokinetics of DA-3031, a pegylated granulocyte colony-stimulating factor (pegylated-G-CSF): a dose block-randomized, double-blind, dose-escalation study in healthy subjects

Ahn LY, Shin KH, Lim KS, Kim TE, Jeon H, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Drug Investig 2013,Nov;33(11):817-24.
368

Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance

Shin KH, Choi MH, Lim KS, Yu KS, Jang IJ, Cho JY.

Clin Pharmacol Ther 2013,Nov;94(5):601-9. doi: 10.1038/clpt.2013.128. Epub 2013 Jun 19.
369

Comparison of pharmacokinetics between new quinolone antibiotics: the zabofloxacin hydrochloride capsule and the zabofloxacin aspartate tablet

Han H, Eun Kim S, Shin KH, Lim C, Soo Lim K, Yu KS, Cho JY.

Curr Med Res Opin 2013,Oct;29(10):1349-55. doi: 10.1185/03007995.2013.825591. Epub 2013 Aug 19.
370

Usefulness of oral loading of oxcarbazepine suspension in selected patients with epilepsy

Kim DW, Gu N, Lee H, Jang IJ, Chu K, Yu KS, Cho JY, Yoon SH, Na HJ, Lee SK.

Int J Clin Pharmacol Ther 2013,Oct;51(10):780-6. doi: 10.5414/CP201896.
371

Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine

Chaturvedula A, Sale ME, Lee H.

J Clin Pharmacol 2013,Sep;doi: 10.1002/jcph.176. [Epub ahead of print]
372

Ambulatory Blood Pressure Response to Once-Daily Fimasartan: An 8-Week, Multicenter, Randomized, Double-Blind, Active-Comparator, Parallel-Group Study in Korean Patients With Mild To Moderate Essential Hypertension

Lee H, Kim KS, Chae SC, Jeong MH, Kim DS, Oh BH

Clin Ther 2013,Sep;35(9):1337-49. doi: 10.1016/j.clinthera.2013.06.021. Epub 2013 Aug 7.
373

GC-MS-Based Quantitative Signatures of Cytochrome P450-Mediated Steroid Oxidation Induced by Rifampicin

Moon JY, Kang SM, Lee J, Cho JY, Moon MH, Jang IJ, Chung BC, Choi MH.

Ther Drug Monit 2013,Aug;35(4):473-84. doi: 10.1097/FTD.0b013e318286ee02.
374

Pharmacokinetic-pharmacodynamic modelling of biomarker response to sitagliptin in healthy volunteers

Kim BH, Kim SE, Kang D, Lim KS, Kim JR, Jang IJ, Shin SG, Yoon SH, Cho JY, Yu KS.

Basic Clin Pharmacol Toxicol 2013,Aug;113(2):113-25. doi: 10.1111/bcpt.12068. Epub 2013 May 20.
375

Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Subjects

Cha YJ, Lee H, Gu N, Kim TE, Lim KS, Yoon SH, Chung JY, Jang IJ, Shin SG, Yu KS, Cho JY.

Basic Clin Pharmacol Toxicol 2013,Jul;doi: 10.1111/bcpt.12108. [Epub ahead of print]
376

건강한 한국인 자원자에서 보글리보스 제제의 약효 동등성 평가 항목 선정을 위한 위약 대조, 단회 및 반복 투여 후 약력학 특성 비교 임상시험

장경호, 조상헌, 김정렬, 정재용, 임경수, 장인진, 유경상.

대한임상약리학회지 2013,Jun; 21(1):63-70
377

건강한 한국인에서 Zofenopril의 약동/약력학적 특성 및 내약성에 관한 무작위, 위약대조, 이중맹검, 평행군, 반복투여, 단계적 증량 임상연구

오재성, 이승환, 임경수, 정재용, 신상구, 장인진, 유경상.

대한임상약리학회지 2013,Jun; 21(1):52-62
378

건강한 자원자에서 무르페ⓡ 패치와 트라스트ⓡ 패치 투여 시 약동학적 특성 및 피부자극성을 비교 평가하기 위한 무작위배정, 공개, 2-Way 교차 임상 연구

최윤정, 김영미, 정재용, 조주연, 유경상, 장인진, 임경수.

대한임상약리학회지 2013,Jun; 21(1):41-51
379

Pharmacokinetic and Pharmacodynamic Effects of Prasugrel in Healthy Korean Males

Yu KS, Park KW, Kelly RP, Gu N, Payne C, Small DS, Choi HC, Kawakatsu E, Pinton P.

J Cardiovasc Pharmacol 2013,Jun;62(1):72-77.
380

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics

Chung JY, Cho SK, Kim TH, Kim KH, Jang GH, Kim CO, Park EM, Cho JY, Jang IJ, Choi JH.

Pharmacogenet Genomics 2013,Jun;23(7):365-73. doi: 10.1097/FPC.0b013e3283622037.
381

Pharmacokinetic study of single and multiple oral administrations of 2 mg dienogest in healthy Korean women

Shin D, Lee S, Lim KS, Park JS, Shin SG, Jang IJ, Yu KS.

Contraception 2013,Jun;87(6):750-5. doi: 10.1016/j.contraception.2012.10.033. Epub 2012 Dec 4.
382

The effect of udenafil on the hemodynamics of healthy male volunteers administered tamsulosin

Kim MG, Kim JR, Kim BH, Lim KS, Shin SG, Jang IJ, Yu KS, Cho JY.

Curr Med Res Opin 2013,Jun;29(6):685-93. doi: 10.1185/03007995.2013.792792. Epub 2013 Apr 17.
383

Population pharmacokinetics of theophylline in premature Korean infants

Kim SE, Kim BH, Lee S, Sohn JA, Kim HS, Cho JY, Yoon SH, Jang IJ, Yu KS, Lim KS.

Ther Drug Monit 2013,Jun;35(3):338-44. doi: 10.1097/FTD.0b013e3182866695.
384

The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18)F]FDG imaging study with aripiprazole

Kim E, Howes OD, Turkheimer FE, Kim BH, Jeong JM, Kim JW, Lee JS, Jang IJ, Shin SG, Kapur S, Kwon JS.

Psychopharmacology (Berl) 2013,May;227(2):221-9. doi: 10.1007/s00213-012-2953-0. Epub 2012 Dec 28.
385

Pharmacokinetic and pharmacodynamic properties of a new long-acting granulocyte colony-stimulating factor (HM10460A) in healthy volunteers

Shin KH, Kim TE, Lim KS, Yoon SH, Cho JY, Kim SE, Park KM, Shin SG, Jang IJ, Yu KS.

BioDrugs 2013,Apr;27(2):149-58. doi: 10.1007/s40259-013-0010-0.
386

Exploration of optimal dosing regimens of haloperidol, a D2 Antagonist, via modeling and simulation analysis in a D2 receptor occupancy study

Lim HS, Kim SJ, Noh YH, Lee BC, Jin SJ, Park HS, Kim S, Jang IJ, Kim SE.

Pharm Res 2013,Mar;30(3):683-93. doi: 10.1007/s11095-012-0906-2. Epub 2012 Nov 10.
387

Global metabolomics and targeted steroid profiling reveal that rifampin, a strong human PXR activator, alters endogenous urinary steroid markers

Kim B, Moon JY, Choi MH, Yang HH, Lee S, Lim KS, Yoon SH, Yu KS, Jang IJ, Cho JY.

J Proteome Res 2013,Mar;12(3):1359-68. doi: 10.1021/pr301021p. Epub 2013 Jan 28.
388

Effect of dissolved oxygen in alcoholic beverages and drinking water on alcohol elimination in humans.

Rhee SJ, Chae JW, Song BJ, Lee ES, Kwon KI.

Alcohol 2013,Feb;47(1):27-30.
389

Impact of ABCC2, ABCG2 and SLCO1B1 Polymorphisms on the Pharmacokinetics of Pitavastatin in Humans

Oh ES, Kim CO, Cho SK, Park MS, Chung JY.

Drug Metab Pharmacokinet 2013,Jan;28(3):196-202. Epub 2012 Sep 25.
390

Serum cystatin C is a major predictor of vancomycin clearance in a population pharmacokinetic analysis of patients with normal serum creatinine concentrations

Chung JY, Jin SJ, Yoon JH, Song YG.

J Korean Med Sci 2013,Jan;28(1):48-54. doi: 10.3346/jkms.2013.28.1.48. Epub 2013 Jan 8.
391

Apple juice greatly reduces systemic exposure to atenolol

Jeon H, Jang IJ, Lee S, Ohashi K, Kotegawa T, Ieiri I, Cho JY, Yoon SH, Shin SG, Yu KS, Lim KS.

Br J Clin Pharmacol 2013,Jan;75(1):172-9. doi: 10.1111/j.1365-2125.2012.04324.x.
392

Increased systemic exposure of fimasartan, an angiotensin II receptor antagonist, by ketoconazole and rifampicin

Kim JW, Yi S, Kim TE, Lim KS, Yoon SH, Cho JY, Lee MG, Song IS, Shin SG, Jang IJ, Yu KS.

J Clin Pharmacol 2013,Jan;53(1):75-81. doi: 10.1177/0091270011433328. Epub 2013 Jan 24.
393

Pharmacokinetic Characteristics of Cefcapene Pivoxil Hydrochloride after Single Oral Administration in Healthy Korean Subjects

이수진, 신광희, 차유정, 김정렬, 오달석, 조주연, 유경상, 장인진, 정재용, 임경수

Translational and Clinical Pharmacology 2013,Jan;2013, vol.21, no.2, pp. 104-112 (9 pages) 건강한 한국인 피험자에서 염산세프카펜 피복실 단회 경구투여 시 약동학적 특성에 관한 연구
394

Investigation Study on Gender Difference Based on Korean Data Related to Drug Use

이수진, 이병요, 권광일

한국임상약학회지 2013,Jan;2013, vol.23, no.2, pp. 114-122 (9 pages) 의약품 사용 관련 국내 통계자료에 나타난 성별 차이 조사 연구
395

Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects

Lee S, Kim BH, Lim K, Stalker D, Wisemandle W, Shin SG, Jang IJ, Yu KS.

J Clin Pharm Ther 2012,Dec;37(6):698-703
396

Pharmacodynamic comparison of two formulations of Acarbose 100-mg tablets

Lee S, Chung JY, Hong KS, Yang SH, Byun SY, Lim HS, Shin SG, Jang IJ, Yu KS.

J Clin Pharm Ther 2012,Oct;37(5):553-7.
397

The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: A randomized controlled trial

Park WB, Kim NH, Kim KH, Lee SH, Nam WS, Yoon SH, Song KH, Choe PG, Kim NJ, Jang IJ, Oh MD, Yu KS.

Clin Infect Dis 2012,Oct; 55(8):1080-7.
398

Multiple-dose pharmacokinetics of fesoterodine sustained-release in healthy Korean volunteers

Shin D, Shin KH, Lee S, Lim KS, Cho JY, Jang IJ, Shin SG, Yu KS.

Int J Clin Pharmacol Ther 2012,Oct;50(10):722-8
399

Assessment of the effect of mirodenafil on the hemodynamics of healthy male korean volunteers administered tamsulosin: a randomized, double-blind, placebo-controlled, 2-period crossover study

NY Gu, JW Kim, KS Lim, KH Shin, TE Kim, BY Lee, SG Shin, IJ Jang, KS Yu.

Clin Ther 2012,Sep;34(9):1929-1939
400

Evaluation of the pharmacokinetics, food effect, pharmacodynamics, and tolerability of DA-1229, a dipeptidyl peptidase IV inhibitor, in healthy volunteers: first-in-human study

TE Kim, KS Lim, MK Park, SH Yoon, JY Cho, SG Shin, IJ Jang, KS Yu.

Clin Ther 2012,Sep;34(9):1986-1998
401

Highly variable pharmacokinetics of once-daily intravenous busulfan when combined with fludarabine in pediatric patients: phase I clinical study for determination of optimal once-daily busulfan dose using pharmacokinetic modeling

Lee JW, Kang HJ, Lee SH, Yu KS, Kim NH, Yuk YJ, Jang MK, Han EJ, Kim H, Song SH, Park KD, Shin HY, Jang IJ, Ahn HS.

Biol Blood Marrow Transplant 2012,Jun;18(6):944-50
402

Assessment of the analgesic effect of remifentanil using three pain models in healthy Korean volunteers: a randomized, controlled study

Kim TE, Kim KP, Shin D, Chung YJ, Price J, Mistry P, Jang IJ, Yu KS.

Basic Clin Pharmacol Toxicol 2012,Jun;110(6):518-23.
403

Assessment of the pharmacokinetics of co-administered metformin and lobeglitazone, a thiazolidinedione antihyperglycemic agent, in healthy subjects

Shin D, Kim TE, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Curr Med Res Opin 2012,Jun;28(7):1213-20.
404

The effect of fimasartan, an angiotensin receptor type 1 blocker, on the pharmacokinetics and pharmacodynamics of warfarin in healthy korean male volunteers: a one-sequence, two-period crossover clinical trial

Gu N, Kim BH, Lim KS, Kim SE, Nam WS, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Ther 2012,Jun;34(7):1592-600.
405

Apple juice greatly reduces systemic exposure to atenolol

Jeon HW, Jang IJ, Lee S, Ohashi K, Kotegawa T, Ieiri I, Cho JY, Yoon SH, Shin SG, Yu KS, Lim KS.

Br J Clin Pharmacol 2012,May;doi: 10.1111/j.1365-2125.2012.04324.x. [Epub ahead of print]
406

Pharmacokinetic and pharmacodynamic properties of the calcimimetic agent cinacalcet (KRN1493) in healthy male Korean subjects: a randomized, open-label, single ascending-dose, parallel-group study

Lee S, Gu NY, Kim BH, Lim KS, Shin SG, Jang IJ, Yu KS.

Clin Ther 2012,May;34(5):1160-9.
407

Assessment of pharmacokinetic proportionality of levofloxacin and cyclosporine over a 100-fold dose range in healthy human volunteers

Lim MS, Seong SJ, Park J, Seo JJ, Lee J, Yu KS, Lee HW, Yoon YR.

Expert Opin Drug Metab Toxicol 2012,Apr;8(4):399-405.
408

Pharmacokinetics and pharmacodynamics of oral tolvaptan administered in 15- to 60-mg single doses to healthy Korean men

Yi S, Jeon H, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

J Cardiovasc Pharmacol 2012,Apr;59(4):315-22.
409

Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship

Kim ET, Oliver D Howes, Kim BH, Jeong JM, Lee JS, Jang IJ, Shin SG, FE. Turkheimer, ST Kapur, Kwon JS.

J.Cereb. Blood Flow Metab. 2012,Apr;32(4):759-68
410

A positron emission tomography microdosing study with sertraline in healthy volunteers

Shin KH, Kim KP, Lim KS, Kim JW, Lee YS, Yang BY, Lee JS, Jung JM, Yoon SH, Jang IJ, Yu KS.

Int J Clin Pharmacol Ther 2012,Mar;50(3):224-32.
411

Frequency of CYP2C9 variant alleles, including CYP2C9*13 in a Korean population and effect on glimepiride pharmacokinetics

Lee HW, Lim MS, Lee J, Jegal MY, Kim DW, Lee WK, Jang IJ, Shin JG, Yoon YR.

J Clin Pharm Ther 2012,Feb;37(1):105-11
412

Effect of oseltamivir on bleeding risk associated with warfarin therapy: a retrospective review

Lee SH, Kang HR, Jung JW, Kwon JW, Hong KS, Yu KS, Cho SH.

Clin Drug Investig 2012,Feb;32(2):131-7
413

Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor, HM30181, in healthy Korean male volunteers: single- and multiple-dose randomized, placebo-controlled studies

Kim TE, Gu N, Yoon SH, Cho JY, Park KM, Shin SG, Jang IJ, Yu KS.

Clin Ther 2012,Feb;34(2):482-94
414

Increased systemic exposure of fimasartan, an angiotensin II receptor antagonist, by ketoconazole and rifampicin

Kim JW, Yi S, Kim TE, Lim KS, Yoon SH, Cho JY, Lee MG, Song IS, Shin SG, Jang IJ, Yu KS.

J Clin Pharmacol 2012,Jan;[Epub ahead of print]
415

Pharmacokinetics of a fixed-dose glimepiride/sustained-release metformin combination

Kim KP, Lim KS, Kim BH, Shin HS, Cho JY, Shin SG, Jang IJ, Yu KS.

Int J Clin Pharmacol Ther 2012,Jan;50(2):142-9.
416

Pharmacokinetics of lacosamide in healthy korean male volunteers

Kim SE, Gu NY, Kim BH, Fitchner A, Elshoff JP, Cawello W, Jang IJ, Yu KS.

Pharmacol 2012,Jan;89(3-4):172-8
417

Comparative pharmacokinetics of HD203, a biosimilar of etanercept, with marketed etanercept (Enbrel): a double-blind, single-dose, crossover study in healthy volunteers

Yi S, Kim SE, Park MK, Yoon SH, Cho JY, Lim KS, Shin SG, Jang IJ, Yu KS.

BioDrugs 2012,Jan;26(3):177-84
418

Assessment of the drug-drug interactions between fimasartan and hydrochlorothiazide in healthy volunteer

Jeon HW, Lim KS, Shin KH, Kim JW, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

J Cardiovasc Pharmacol 2012,Jan;59(1):84-91
419

Voriconazole-associated severe hyponatremia

Kim KH, Lee SH, Lee SW, Yun NR, Kim NJ, Yu KS, Jang IJ, Park WB, Oh MD.

Med Mycol J 2012,Jan;50(1):103-5
420

Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase IV inhibitor LC15-0444 and pioglitazone in healthy volunteers

Kim SE, Yi SJ, Shin KH, Kim TE, Kim MJ, Kim YH, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Int J Clin Pharmacol Ther 2012,Jan;50(1):17-23
421

Effect of age on the pharmacokinetics of fimasartan (BR-A-657)

Lee HW, Lim MS, Seong SJ, Lee J, Park J, Seo JJ, Cho JY, Yu KS, Yoon YR.

Expert Opin Drug Metab Toxicol 2011,Nov;7(11):1337-44
422

The effect of the newly developed angiotensin receptor II antagonist fimasartan on the pharmacokinetics of atorvastatin in relation to OATP1B1 in healthy male volunteers

Shin KH, Kim TE, Kim SE, Lee MG, Song IS, Yoon SH, Cho JY, Jang IJ, Shin SG, Yu KS.

J Cardiovasc Pharmacol 2011,Nov;58(5):492-9
423

Imunogenicity and safety of a single intramuscular dose of a diphtheria-tetanus toxoid (Td) vaccine (GC1107) in Korean adults

Lee S, Park WB, Shin KH, Ahn DH, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Vaccine 2011,Oct;29(44):7638-43.
424

Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel

Jung KH, Chu K, Lee ST, Yoon HJ, Chang JY, Nam WS, Yoon SH, Cho JY, Yu KS, Jang IJ, Kim M, Lee SK, Roh JK.

Clin Pharmacol Ther 2011,Oct;90(4):612-9
425

Population pharmacokinetic analysis and dosing regimen optimization of aprotinin in neonates and young infants undergoing cardiopulmonary bypass

Tae YM, Kwak JG, Kim BH, Jang IJ, Kim WH.

J Clin Pharmacol 2011,Aug;51(8):1163-76
426

Effect of CYP2C19 polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers

Lee SH, Kim BH, Nam WS, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

J Clin Pharmacol 2011,Jul;[Epub ahead of print]
427

Pharmacokinetic profiles of ceftazidime after intravenous administration in patients undergoing automated peritoneal dialysis

Kim K, Hwang YH, Ro H, Oh YK, Kim MG, Yu KS, Shin KH, Jang IJ, Shin SG, Ann C, Oh KH.

Antimicrob 2011,Jun;55(6):2523-7. Epub 2011 Mar 14.
428

Pharmacokinetic Interaction of fimasartan, a new angiotensin II receptor antagonist, with amlodipine in healthy volunteers

Yi SJ, Kim TE, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

J Cardiovasc Pharmacol 2011,Jun;57(6):682-9
429

Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans

Kang HR, Jee YK, Kim YS, Lee CH, Jung JW, Kim SH, Park HW, Chang YS, Jang IJ, Cho SH, Min KU, Kim SH, Lee KW.

Pharmacogenet Genomics 2011,May;21(5):303-7.
430

Effect of multiple doses of fimasartan, an angiotension II receptor antagonist, on the steady-state pharmacokinetics of digoxin in healthy volunteers

Yi SJ, Kim JW, Kim TE, Kim J, Jun YK, Choi J, Yoon SH, Cho JY, Song SH, Shin SG, Jang IJ, Yu KS.

Int J Clin Pharmacol Ther 2011,May;49(5):321-7
431

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Chung JY, Cho JY, Lim HS, Kim JR, Yu KS, Lim KS, Shin SG, Jang IJ.

Drug Metab Dispos 2011,Jan; 39(1):92-7
432

The potential inhibitory effect of revaprazan, an acid pump antagonist, on anticoagulation with warfarin

Jung JW, Kang HR, Kwon JW, Kim TE, Lee SH, Hong KS, Yu KS, Cho SH. Tohoku

J Exp Med 2011,Jan;224(4):293-300
433

Verification of biomarkers for diabetic retinopathy by multiple reaction monitoring

Kim K, Kim SJ, Yu HG, Yu J, Park KS, Jang IJ, Kim Y.

J Proteome Res 2010,Feb;(2).9(2):689-699
434

건강자원자에서 LB80380 경구 투여 후 LB80380, LB80920, LB80331 의 약동학적 특성 및 안전성에 관한 연구

김성은, 신광희, 김태은, 이승환, 김보형, 김민정, 윤서현, 조주연, 신상구, 장인진, 유경상

임상약리학회지 2010,Jan;18(1):34-42
435

건강한 한국인 자원자에서 Garenoxacin 단회투여에 의한 약동학적 특성 연구

신동훈, 홍정화, 이소정, 김태은, 장인진, 신상구, 유경상.

임상약리학회지 2010,Jan;18(1):43-52
436

건강한 한국인 자원자에서 나프토피딜(Naftopidil) 단회 경구투여에 의한 약동학적 특성 및 내약성에 관한 연구

차유정, 김정원, 전혜원, 신광희, 이승환, 장인진, 신상구, 유경상.

임상약리학회지 2010,Jan;18(2):127-136
437

건강한 한국인 자원자에서 테오브로민(Theobromine) 500mg 캡슐 반복 투여에 의한 안전성 및 약동학 평가에 관한 연구

김정원, 신광희, 이소정, 김태은, 오세을, 윤서현, 조주연, 유경상, 장인진, 신상구.

임상약리학회지 2010,Jan;18(1):15-22
438

실로스타졸과 은행엽 엑스의 복합제 투여 및 병용투여시 약동학적 특성 및 안전성 비교

전혜원; 이소정, 김성은, 김보형, 임경수, 이봉용, 유경상, 신상구, 장인진.

임상약리학회지 2010,Jan;18(1):5-14
439

Clinical usefulness of serum cystatin C and the pertinent estimation of glomerular filtration rate based on cystatin C

Cha RH, Lee CS, Lim YH, Kim H, Lee SH, Yu KS, Kim YS.

Nephrology (Carlton) 2010,Jan;15(8): 768-776
440

Relative bioavailability and tolerability of two formulations of bicalutamide 50-mg tablets: a randomized-sequence, open-label, two-period crossover study in healthy Korean male subjects

Lee S, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Ther. 2010,Jan;32(14): 2496-2501
441

Ethnic coefficients for glomerular filtration rate estimation by the modification of diet in renal disease study equations in the Korean population

Lee CS, Cha RH, Lim YH, Kim H, Song KH, Gu N, Yu KS, Lim CS, Han JS, Kim S, Kim YS.

J Korean Med Sci 2010,Jan;25: 1616-1625
442

Pharmacokinetic and pharmacodynamic comparison of two recombinant human erythropoietin formulations after single subcutaneous administration: an open-label, sequence-randomized, two-treatment crossover study in healthy Korean male volunteers

Kim TE, Kim KP, Kim BH, Shin SG, Jang IJ, Yu KS.

Clin Ther 2010,Jan;32: 1968-1976
443

Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: a single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers

Gu NY, Kim BH, Rhim H, Chung JY, Kim JR, Shin HS, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Ther 2010,Jan;32: 1408-1418
444

Changes in the QTc interval after administration of flecainide acetate, with and without coadministered paroxetine, in relation to cytochrome P450 2D6 genotype: data from an open-label, two-period, single-sequence crossover study in healthy Korean male subjects

Lim KS, Jang IJ, Kim BH, Kim J, Jeon JY, Tae YM, Yi S, Eum S, Cho JY, Shin SG, Yu KS.

Clin Ther 2010,Jan;32(4): 659-666
445

Effect of ketoconazole on the pharmacokinetics of udenafil in healthy Korean subjects

Shin KH, Chung YJ, Kim BH, Kim TE, Kim HS, Cho JY, Jang IJ, Shin SG, Yu KS.

Brit J Clin Pharmacol 2010,Jan;69(6): 307-310
446

Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers

Kim BH, Kim KP, Lim KS, Kim JR, Yoon SH, Cho JY, Lee YO, Lee KH, Jang IJ, Shin SG, Yu KS.

Clin Ther 2010,Jan;32(2): 380-390
447

Pharmacodynamic (hemodynamic) and pharmacokinetic comparisons of S-amlodipine gentisate and racemate amlodipine besylate in healthy Korean male volunteers: two double-blind, two double-blind, randomized, two-period, two-treatment, randomized, two-period, two-treatment, two-sequence, double-dummy, single-dose crossover studies

Kim BH,Kim JR, Kim MG, Kim KP, Lee BY, Jang IJ, Shin SG, Yu KS.

Clin Ther 2010,Jan;32(1): 193-205
448

한국인 건강 피험자에서 Cytochrome P450 2C19 유전적다형성과 Ketoconazole 병용투여가 Clopidogrel 투여 후 혈소판응집 반응에 미치는 영향

김정렬, 김선정, 김화숙, 엄소영, 신광희, 조주연, 유경상, 신상구, 장인진.

대한임상약리학회지 2009,Jan;17(1):51-60
449

건강한 한국인 자원자에서 말레인산 이르소글라딘의 약동학적 특성에 관한 연구

이승환, 임경수, 김정렬, 김재우, 김보형, 조주연, 윤서현, 신상구, 장인진, 유경상.

대한임상약리학회지 2009,Jan;17(1):35-43
450

Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

Tan B, Naik H, Jang IJ, Yu KS, Kirsch LE, Shin CS, Craft JC, Fleckenstein L.

Malar J 2009,Jan;8(1): 304
451

Pharmacokinetics and pharmacodynamics of LC15-0444, a novel dipeptidyl peptidase IV inhibitor, after multiple dosing in healthy volunteers

Lim KS, Cho JY, Kim BH, Kim JR, Kim HS, Kim DK, Kim SH, Yim HJ, Lee SH, Shin SG, Jang IJ, Yu KS.

Br J Clin Pharmacol 2009,Jan;68(6): 883-90
452

The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study

Shin KH, Kim BH, Kim TE, Kim JW, Yi SJ, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Ther 2009,Jan;3009-3020
453

Comparative pharmacokinetic evaluation of two formulations of bicalutamide 50-mg tablets: an open-label, randomized-sequence, single-dose, two-period crossover study in healthy Korean male volunteers

Lee SH, Chung YJ, Kim BH, Shim JH, Yoon SH, Shin SG , Jang IJ, Yu KS.

Clin Ther 2009,Jan;3000-3008
454

Pharmacokinetic comparison of a new glimepiride 1-mg + metformin 500-mg combination tablet formulation and a glimepiride 2-mg + metformin 500-mg combination tablet formulation: a single- dose, randomized, open-label, two-period, two-way crossover study in healthy, fasting Korean male volunteers

Kim BH, Shin KH, KIm JW, Lim KS, Kim KP, Kim JR, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Ther 2009,Jan;2755-2764
455

Potential interactions between cilostazol and probucol: a two-part, single-dose, open-label study in healthy Korean male volunteers

Kim KP, Kim BH, Lim KS, Kim TE, Shin SG, Jang IJ, Yu KS.

Clin Ther 2009,Jan;31(10): 2098-106
456

Pharmacokinetics of intravenous piperacillin administration in patients undergoing on-line hemodiafiltration

Oh KH, Kim C, Lee H, Lee H, Jung JY, Kim NJ, Yu KS, Shin KH, Jang IJ, Ahn C.

Antimicrob Agents Chemother 2009,Jan;53(8): 3266-8
457

Effect of food on the pharmacokinetics of the oral phosphodiesterase 5 inhibitor udenafil for the treatment of erectile dysfunction

Kim TE, Kim BH, Kim JR, Lim KS, Hong JH, Kim KP, Kim HS, Shin SG, Jang IJ, Yu KS.

Br J Clin Pharmacol 2009,Jan;68(1): 43-6
458

Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea

Kim BH, Yi S, Kim J, Lim KS, Kim KP, Lee B, Shin SG, Jang IJ, Yu KS.

Clin Ther 2009,Jan;31(6): 1234-43
459

Comparison of The pharmacokinetics of ticlopidine between administration of a combined fixed-dose tablet formulation of ticlopidine 250 mg/ginkgo extract 80 mg, and concomitant administration of ticlopidine 250-mg and ginkgo extract 80-mg tablets: An open-label, two-treatment, single-dose, randomized-sequence crossover study in healthy korean male volunteers

Kim TE, Kim BH, Kim J, Kim KP, Yi S, Shin HS, Lee YO, Lee KH, Shin SG, Jang IJ, Yu KS.

Clin Ther 2009,Jan;31(10): 2249-57
460

Effects of angelicae tenuissima radix, angelicae dahuricae radix and scutellariae radix extracts on cytochrome P450 activities in healthy volunteers

Yi S, Cho JY, Lim KS, Kim KP, Kim J, Kim BH, Hong JH, Jang IJ, Shin SG, Yu KS.

Basic Clin Pharmacol Toxicol 2009,Jan;105: 249-256
461

An open-label, single-dose, parallel-group, dose-increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy Korean and Japanese male subjects

Kim BH, Kim JR, Lim KS, Kim JW, Kim KP, Hong JH, Jang IJ, Shin SG, Yu KS, Tanaka T.

Clin Ther 2009,Jan;31(3): 609-618
462

Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy

Kim DW, Lee SK, Chu K, Jang IJ, Yu KS, Cho JY, Kim SJ.

Epilepsy Res 2009,Jan;84(1): 86-90
463

Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis

Kim SH, Kim SH, Bahn JW, Kim YK, Chang YS, Shin ES, Kim YS, Park JS, Kim BH, Jang IJ, Song J, Kim SH, Park HS, Min KU, Jee YK.

Pharmacogenomics 2009,Jan;10(11): 1767-79
464

Optimal dose of intravenous pantoprazole in patients with peptic ulcer bleeding requiring endoscopic hemostasis in Korea

Choi KD, Kim N, Jang IJ, Park YS, Cho JY, Kim JR, Shin JM, Jung HC, Song IS.

J Gastroenterol Hepatol 2009,Jan;24(10): 1617-24
465

Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma

Kim W, Yoon JH, Kim JR, Jang IJ, Bang YJ, Kim YJ, Lee HS.

Cancer Chemother Pharmacol 2009,Jan;64(3): 497-507
466

Association between tumor necrosis factor alpha 308G/a polymorphism and increased proinflammatory cytokine release after cardiac surgery with cardiopulmonary bypass in the Korean population

Yoon SZ, Jang IJ, Choi YJ, Kang MH, Lim HJ, Lim YJ, Lee HW, Chang SH, Yoon SM.

J Cardiothorac Vasc Anesth 2009,Jan;23(5): 646-50
467

Pharmacokinetics of hydroxychloroquine and its clinical implications in the chemoprophylaxis malaria caused by plasmodium vivax

Lim HS, Im JS, Cho JY, Bae KS, Klein TA, Yeom JS, Kim TS, Choi JS, Jang IJ, Park JW.

Antimicrob Agents Chemother 2009,Jan;(4)
468

Gastroprotective action of cochinchina momordica seed extract is medicted by activation of CGRP and inhibition of cPla(2)/5-LOX pathway

Kang JM, Kim N, Kim B, Kim JH, Lee BY, Park JH, Lee MK, Lee HS, Jang IJ, Kim JS, Jung HC, Song IS

Dig Dis Sci 2009,Jan;(1)
469

Duplex pyrosequencing assay of the 388A>G and 521T>C SLCO1B1 polymorphisms in three asian populations

Kim EY, Cho DY, Shin HJ, Lee SS, Shon JH, Shin JG, Shin SG.

Clin Chim Acta 2008,Feb;388(1-2):68-72
470

기존제형 S-amlodipine gentisate 에 대한 변경제형 S-amlodipine gentisate 의 생물학적동등성 연구

최윤정, 김민걸, 김보형, 유경상, 장인진, 신상구.

대한임상약리학회지 2008,Jan;16(1):37-44
471

한국인 소아에서 반코마이신의 집단약동학에 관한 연구

전지영, 김정렬, 임경수, 정용주, 유경상, 장인진, 신상구.

대한임상약리학회지 2008,Jan;16(1):21-36
472

Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole

Kwon JS, Kim E, Kang DH, Choi JS, Yu KS, Jang IJ, Shin SG, Aplus Study Group.

Eur Neuropsychopharmacol 2008,Jan;18(12): 897-907
473

Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients

Kim JR, Seo HB, Cho JY, Kang DH, Kim YK, Bahk YM, Yu KS, Shin SG, Kwon JS, Jang IJ.

Brit J Clin Pharmacol 2008,Jan;66(6): 802-810
474

Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects

Lim KS, Cho JY, Jang IJ, Kim BH, Kim JW, Jeon JY, Tae YM, Yi S, Eum SY, Shin SG, Yu KS.

Brit J Clin Pharmacol 2008,Jan;66(5): 660-666
475

Pharmacokinetics, pharmacodynamics, and tolerability of the dipeptidyl peptidase IV inhibitor LC15-0444 in healthy Korean men: a dose-block-randomized, double-blind, placebo-controlled, ascending single-dose, phase I study

Lim KS, Kim JR, Choi YJ, Shin KH, Kim KP, Hong JH, Cho JY, Shin HS, Yu KS, Shin SG, Kwon OH, Hwang DM, Kim JA, Jang IJ.

Clin Ther 2008,Jan;30(10): 1817-1830
476

Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations

Myrand SP, Sekiguchi K, Man MZ, Lin X, Tzeng RY, Teng CH, Hee B, Garrett M, Kikkawa H, Lin CY, Eddy SM, Dostalik J, Mount J, Azuma J, Fujio Y, Jang IJ, Shin SG, Bleavins MR, Williams JA, Paulauskis JD, Wilner KD.

Clin Pharmacol Ther 2008,Jan;84(3): 347-361
477

Effect of the CYP2C19 polymorphism on the eradication rate of helicobacter pylori infection by 7-day triple therapy with regular proton pump inhibitor dosage

Kang JM, Kim N, Lee DH, Park YS, Kim JS, Chang IJ, Song IS, Jung HC.

J Gastroenterol Hepatol 2008,Jan;23(8): 1287-1291
478

Safety, tolerability and pharmacokinetics of Udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects

Kim BH, Lim HS, Chung JY, Kim JR, Lim KS, Sohn DR, Cho JY, Yu KS, Shin SG, Paick JS, Jang IJ.

Brit J Clin Pharmacol 2008,Jan;65(6): 660-666
479

Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects

JY Chung, JY Cho, KS Yu, JR Kim, KS Lim, DR Sohn, SG Shin, and IJ Jang.

Clin Pharmacol Ther 2008,Jan;83(4): 595-600
480

Taq1A polymorphism in the dopamine D2 receptor gene predicts brain metabolic response to aripiprazole in healthy male volunteers

Kim E, Kwon JS, Shin YW, Lee JS, Kang WJ, Jo HJ, Lee JM, Yu KS, Kang DH, Cho JY, Jang IJ, Shin SG.

Pharmacogenet Genomics 2008,Jan;18(2): 91-97
481

Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil

Lee HS, Park EJ, Ji HY, Kim SY, Im GJ, Lee SM, Jang IJ.

Xenobiotica 2008,Jan;38(1): 21-33
482

Visualization of CYP2D6 genotype to phenotype correlation in Korean

Kim EY, Jung HJ, Lee SS, Shon JH, Shin SG, Shin JG.

AMIA Annu Symp Proc 2007,Oct;1009-10
483

약물유전학 소개

장인진

대한임상약리학회지 2007,Jan;15(1):5-19
484

신약임상개발 (Clinical development of new drugs)

유경상

Medical Postgraduates 2007,Jan;35(4):239-243
485

건강한 한국인 자원자에서 Desloratadine 단회투여에 의한 약동학적 특성 연구

이소정, 임경수, 김보형, 김재우, 김정렬, 정재용, 조주연, 유경상, 장인진, 신상구.

대한임상약리학회지 2007,Jan;15(1):46-56
486

건강한 한국인 피험자에서 베실산베포타스틴의 약동학 특성에 대한 연구

김보형, 정재용, 김정렬, 임경수, 임형석, 유경상, 장인진, 신상구.

대한임상약리학회지 2007,Jan;15(1):37-45
487

건강 피험자에서 lafutidine의 약동학 특성에 관한 연구

김보형, 김정렬, 임경수, 김재우, 김상린, 조주연, 유경상, 장인진, 신상구.

대한임상약리학회지 2007,Jan;15(1):28-36
488

Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer

Lim HS, Ju Lee H, Seok Lee K, Sook Lee E, Jang IJ, Ro J.

J Clin Oncology 2007,Jan;25(25): 3837-3845
489

MRP2 haplotypes confer differential susceptibility to toxic liver injury

Choi JH, Ahn BM, Yi J, Lee JH, Lee JH, Nam SW, Chon CY, Han KH, Ahn SH, Jang IJ, Cho JY, Suh Y, Cho MO, Lee JE, Kim KH, Lee MG.

Pharmacogenet Genomics 2007,Jan;17(6): 403-415
490

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Vossen M, Sevestre M, Niederalt C, Jang IJ, Willmann S, Edginton AN.

Theor Biol Med Model 2007,Jan;26(4): 13
491

Modeling of brain D2 receptor occupancy-plasma concentration relationships with a novel antipsychotic, YKP1358, using serial PET scan in healthy volunteers

KS Lim, JS Kwon, IJ Jang, JM Jeong, JS Lee, HW Kim, WJ Kang, JR Kim, JY Cho, E Kim, SY Yoo, SG Shin, Yu KS.

Clin Pharmacol Ther 2007,Jan;81(2): 252-258
492

Angiotensin II Type 1 receptor 1166A/C polymorphism in association with blood pressure response to exogenous angiotensin II

Lim HS, Cho JY, Oh DS, Chung JY, Hong KS, Bae KS, Yu KS, Lee KH, Jang IJ, Shin SG.

European J Clin Pharmacol 2007,Jan;63(1): 17-26
493

Comparative pharmacokinetic and bioequivalence evaluation of two formulations of morniflumate 350-mg tablets in healthy male subjects .

Lee H, Yim SV, Kim BH, Lee S.

Int J Clin Pharmacol Ther 2007,Jan;55(1):95-101. doi: 10.5414/CP202678.
494

External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old

Sang Hwan Ji, Ji Hyun Lee, Joo Youn Cho, Hwa Suk Kim, Young Eun Jang, Eun Hee Kim, Jin Tae Kim, Hee Soo Kim

J Korean Med Sci . 2007,Jan;23;35(11):e70

There are total 494 results.

Department of Clinical Pharmacology and Therapeutics of Seoul National University Hospital (SNUCPT) Seoul National University Hospital Main building 8322 Tel : +82-2-2072-4081FAX : +82-2-2072-2960

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