RESEARCH
OCT3 promoter haplotype is associated with metformin pharmacokinetics in Koreans
Kim EJ, Oh J, Lee K, Yu KS, Chung JY, Hwang JH, Nam EY, Kim HS, Kim M, Park JS, Song KH, Kim ES, Song J, Kim HB
Scientific reports 2018,Nov;16;8(1):16965.
Physiologically Based Pharmacokinetic Modeling of Fimasartan, Amlodipine, and Hydrochlorothiazide for the Investigation of Drug-Drug Interaction Potentials
Rhee SJ, Lee HA, Lee S, Kim E, Jeon I, Song IS, Yu KS
Pharmaceutical research. 2018,Oct;15;35(12):236.
Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment.
Kim AH, Yoon S, Lee Y, Lee J, Bae E, Lee H, Kim DK, Lee S, Yu KS, Jang IJ, Cho JY
Journal of Korean medical science 2018,Oct;31;33(53):e298.
The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs
Park HW, Kim SH, Chang YS, Kim SH, Jee YK, Lee AY, Jang IJ, Park HS, Min KU
Allergy Asthma Immunol Res 2018,Sep;10(5):555-561.
Lack of a Clinically Significant Pharmacokinetic Interaction Between Pregabalin and Thioctic Acid in Healthy Volunteers
Rhee SJ, Lee H, Ahn LY, Lim KS, Yu KS
Clinical therapeutics 2018,Sep;40(10):1720-1728.e2.
Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity.
Oh J, Yi S, Gu N, Shin D, Yu KS, Yoon SH, Cho JY, Jang IJ
Genomics & informatics. 2018,Sep;16(3):52-58.
Safety and efficacy of fimasartan with essential hypertension patients in real world clinical practice: data from a post marketing surveillance in Korea.
Su-Eun Han, Seung Hee Jeong, Hye Jeong Kang, Myung Sook Hong, Eunah Paek, Hijung Cho, Seong Choon Choe
Translational and clinical pharmacology. 2018,Sep;26(3):118-127. doi: 10.12793/tcp.2018.26.3.118. Epub 2018 Sep 14.
Clinical characteristics and satisfaction with the fimasartan in Korean hypertensive patients: a prospective, cross-sectional and open-label, 8-week switching study (Kanarb-hypertension epidemiology medication satisfaction study; K-HEMS study).
Dong Joo Oh, Su-Eun Han, Seung Hee Jeong, Myung Sook Hong, Seong Choon Choe
Clinical hypertension. 2018,Sep;1;24:10. doi: 10.1186/s40885-018-0096-2. eCollection 2018.
Comparison of the pharmacokinetics and tolerability of montelukast/levocetirizine administered as a fixed-dose combination and as separate tablets
Seokuee Kim, Jae-Wook Ko, Jung-Ryul Kim
International journal of clinical pharmacology and therapeutics. 2018,Sep;56(9):443-450. doi: 10.5414/CP203265.
Regulation of Endogenic Metabolites by Rosuvastatin in Hyperlipidemia Patients: An Integration of Metabolomics and Lipidomics
Lee H, Choi JM, Cho JY, Kim TE, Lee HJ, Jung BH
Chemistry and physics of lipids. 2018,Aug;214:69-83
"Ursodeoxycholic acid improves liver function via phenylalanine/ tyrosine pathway and microbiome remodelling in patients with liver dysfunction"
Kim DJ, Yoon S, Ji SC, Yang J, Kim YK, Lee S, Yu KS, Jang IJ, Chung JY, Cho JY
Scientific reports 2018,Aug;8;8(1):11874.
A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers
Lee S, Kim Y, Lee JJ, SIm G, Cho JY, Chung JY,, Yoon S
European journal of clinical pharmacology 2018,Aug; doi: 10.1007/s00228-018-2543-0. [Epub ahead of print]
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.
Yang EJ, Mahmood U, Kim H, Choi M, Choi Y, Lee JP, Cho JY, Hyun JW, Kim YS, Chang MJ, Kim HS
Free radical biology and medicine 2018,Aug;126:221-234.
"HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model"
Tsogbadrakh B, Ju KD, Lee J, Han M, Koh J, Yu Y, Lee H, Yu KS, Oh YK, Kim HJ, Ahn C, Oh KH
PLoS ONE 2018,Aug;30;13(8):e0201692
pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects.
Jung-Ryul Kim, Seokuee Kim, Wooseong Huh, Jae-Wook Ko
Drug design, development and therapy. 2018,Aug;10;12:2475-2483. doi: 10.2147/DDDT.S172568. eCollection 2018.
Favorable outcome of post-transplantation cyclophosphamide haploidentical peripheral blood stem cell transplantation with targeted busulfan-based myeloablative conditioning using intensive pharmacokinetic monitoring in pediatric patients.
Hong KT, Kang HJ, Choi JY, Hong CR, Cheon JE, Park JD, Park KD, Song SH, Yu KS, Jang IJ, Shin HY
Biol Blood Marrow Transplant 2018,Jul; pii: S1083-8791(18)30383-5.
Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects
Sunwoo J, Oh J, Moon SJ, Ji SC, Lee SH, Yu KS, Kim HS, Lee A, Jang IJ
Aliment. Pharmacol. Ther 2018,Jul;;48(2):206-218.
Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers
Yewon Choi, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu
Drug Des Devel Ther 2018,Jul;24;12:2301-2309.
Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic.
Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY.
Drug Des Devel Ther 2018,Jun;11;12:1707-1714.
Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects.
Kim E, Kim A, Yi S, Kim YK, Jang SB, Byun HM, Yoon SH, Cho JY, Jang IJ, Yu KS, Lee S
European journal of clinical pharmacology 2018,Jun;74(10):1261-1272.
Identification of ω- or (ω-1)-hydroxylated medium-chain acylcarnitines as novel urinary biomarkers for CYP3A activity.
kim B, Lee J, Shin KH, Lee S, Yu KS, Jang IJ, Cho JY.
Clin Pharmacol Ther 2018,May;2018 May;103(5):879-887. doi: 10.1002/cpt.856. Epub 2017 Oct 10.
The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers.
Moschetti V, Kim M, Sand M, Wunderlich G, Andersen G, Feifel U, Jang IJ, Timmer W, Rosenbrock H, Boland K
Eur Neuropsychopharmacol 2018,May;;28(5):643-655.
Identification of ω- or (ω-1)-Hydroxylated Medium-Chain Acylcarnitines as Novel Urinary Biomarkers for CYP3A Activity.
Kim B, Lee J, Shin KH, Lee S, Yu KS, Jang IJ, Cho JY.
Clin Pharmacol Ther 2018,May;103(5):879-887.
A phase 4 study of nilotinib in Korean patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTKorea
Shin J, Koh Y, Yoon SH, Cho JY, Kim DY, Lee KH, Kim HJ, Ahn JS, Kim YK, Park J, Sohn SK, Moon JH, Lee YJ, Yoon S, Lee JO, Cheong JW, Kim KH, Kim SH, Kim HG, Kim H, Nam SH, Do YR, Park SG, Park SK, Bae SH, Song HH, Shin DY, Oh D, Kim MK, Jung CW, Park S, Kim I
Cancer medicine 2018,May;7(5):1814-1823
Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet.
Lee S, Nam KY, Oh J, Lee S, Cho SM, Choi YW, Cho JY, Lee BJ, Hong JH
Drug Des Devel Ther 2018,May;23;12:1413-1420.
Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese
Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ.
Drug Des Devel Ther 2018,Apr;30;12:1045-1051
Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker
Kim AH, Kim B, Rhee SJ, Lee Y, Park JS, Lee SM, Kim SM, Lee S, Yu KS, Jang IJ, Cho JY
Drug metabolism and pharmacokinetics 2018,Apr;33(3):173-178.
Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians
Lee J, Rhee SJ, Lee S, Yu KS
Drug Des Devel Ther 2018,Apr;6;12:787-794.
The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension.
Suh HJ, Yoon SH, Yu KS, Cho JY, Park SI, Lee E, Lee JO, Koh Y, Song KH, Choe PG, Kim ES, Bang SM, Kim HB, Kim I, Kim NJ, Song SH, Park WB, Oh MD
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2018,Apr; 26;62(7).
Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet
Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH
Drug Des Devel Ther 2018,Apr;20;12:935-942
Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram.
Yoon S, Park KR, Lee S, Song SH, Park WB, Jang IJ, Yu KS.
Basic Clin Pharmacol Toxicol 2018,Feb;2018 Feb;122(2):233-238. doi: 10.1111/bcpt.12873. Epub 2017 Sep 6.
Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients With Hematologic Malignancies.
"Suh HJ, Kim I, Cho JY, Park SI, Yoon SH, Hwang JH, Bae JY, Lee JO, Koh Y, Song KH, Choe PG, Yu KS, Kim ES, Kim HB, Bang SM, Kim NJ, Song SH, Park WB, Oh MD"
Ther Drug Monit 2018,Feb;;40(1):115-119.
Basic Clin Pharmacol Toxicol 2018,Feb;122(2):233-238.
Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects.
"Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S."
Drug Des Devel Ther 2018,Feb;19;12:331-337.
Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study.
Lee S, Hwang JG, Park SY, Lim HJ, Lee SW, Seo MH, Kim J, Hong JH
Advances in therapy 2018,Feb;35(2):210-217.
Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study.
Oh J, Lee S, Kim A, Yoon J, Jang K, Lee DH, Cho S, Lee SR, Yu KS, Chung JY
J Clin Pharmacol 2018,Jan;2018 Jan;58(1):64-73. doi: 10.1002/jcph.973. Epub 2017 Aug 16.
S-1-Induced Lacrimal Drainage Obstruction and its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-Institutional Study.
Kim N, Kim JW, Baek JH, Kim JS, Choung HK, Kim TY, Lee KH, Bang YJ, Khwarg SI, Ahn SH, Park DJ, Kim HH, Chung JY, Ahn S, Lee KW.
Cancer Res Treat 2018,Jan;2018 Jan;50(1):30-39. doi: 10.4143/crt.2016.569. Epub 2017 Feb 27.
Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects.
Choi Y, Lee SW, Kim A, Jang K, Nam H, Cho YL, Yu KS, Jang IJ, Chung JY.
J Antimicrob Chemother 2018,Jan;1;73(1):183-190.
A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study.
Chung H, Oh J, Yoon SH, Yu KS, Cho JY, Chung JY
PloS one 2018,Jan;17;13(1):e0191258
Oh J, Lee S, Kim A, Yoon J, Jang K, Lee DH, Cho S, Lee SR, Yu KS, Chung JY.
J Clin Pharmacol 2018,Jan;;58(1):64-73.
S-1-Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study.
"Kim N, Kim JW, Baek JH, Kim JS, Choung HK, Kim TY, Lee KH, Bang YJ, Khwarg SI, Ahn SH, Park DJ, Kim HH, Chung JY, Ahn S, Lee KW."
Cancer Res Treat 2018,Jan;50(1):30-39.