RESEARCH
Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects.
Kim Y, Yoon S, Choi Y, Yoon SH, Cho JY, Jang IJ, Yu KS, Chung JY
Sci Rep 2019,Dec;19;9(1):19410.
Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects.
Yang E, Lee S, Lee H, Hwang I, Jang IJ, Yu KS, Lee S
Transl Clin Pharmacol 2019,Dec;27(4):134-140
Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects
Yun Kim, Seonghae Yoon, Yewon Choi, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung
Scientific reports. 2019,Dec;2019 Dec 19;9(1):19410. doi: 10.1038/s41598-019-55562-4.
Pharmacokinetic Interaction Among Telmisartan, Amlodipine, and Hydrochlorothiazide After a Single Oral Administration in Healthy Male Subjects.
Moon SJ, Jeon JY, Yu KS, Kim MG
Clin Ther. 2019,Nov;41(11):2273-2282
Author Correction: Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction.
Kim DJ, Yoon S, Ji SC, Yang J, Kim YK, Lee S, Yu KS, Jang IJ, Chung JY, Cho JY
Sci Rep. 2019,Nov;13;9(1):17003
A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects.
Kim E, Park KR, Jang IJ, Yu KS, Lee S
Drug Des Devel Ther 2019,Nov;13;13:3879-3885
Influence of midazolam-related genetic polymorphism on conscious sedation during upper gastrointestinal endoscopy in a Korean population.
Park JY, Kim BJ, Lee SW, Kang H, Kim JW, Jang IJ, Kim JG
Sci Rep 2019,Nov;5;9(1):16001
URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers
Hyun A Lee, Kyung-Sang Yu, Sang-In Park, Seonghae Yoon, Makoto Onohara, Youngjoo Ahn, Howard Lee
Rheumatology. 2019,Nov;2019 Nov 1;58(11):1976-1984. doi: 10.1093/rheumatology/kez140.
Effects of Celecoxib on the QTc Interval: A Thorough QT/QTc Study.
Seokuee Kim, Hyeryeon Lee, Jae-Wook Ko, Jung-Ryul Kim
Clinical therapeutics. 2019,Nov;41(11):2204-2218. doi: 10.1016/j.clinthera.2019.09.004. Epub 2019 Sep 26.
A safety, pharmacokinetic, pharmacogenomic and population pharmacokinetic analysis of the third-generation EGFR TKI, olmutinib (HM61713), after single oral administration in healthy volunteers.
Young Su Noh, Seonghae Yoon, Suk Ran Kim, Kyung‐Tae Lee, In‐Jin Jang
Basic Clin Pharmacol Toxicol 2019,Oct;125(4):370-381
Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis.
Kim DJ, Cho EJ, Yu KS, Jang IJ, Yoon JH, Park T, Cho JY
Cancers (Basel) 2019,Oct;6;11(10)
ST2 blockade mitigates peritoneal fibrosis induced by TGF-β and high glucose.
Kim YC, Kim KH, Lee S, Jo JW, Park JY, Park MS, Tsogbadrakh B, Lee JP, Lee JW, Kim DK, Oh KH, Jang IJ, Kim YS, Cha RH, Yang SH
J Cell Mol Med 2019,Oct;23(10):6872-6884
Indoxyl sulfate-induced TNF-α is regulated by crosstalk between the aryl hydrocarbon receptor, NF-κB, and SOCS2 in human macrophages
Hee Young Kim, Tae-Hyun Yoo, Joo-Youn Cho, Hyeon Chang Kim, Won-Woo Lee
FASEB J . 2019,Oct;2019 Oct;33(10):10844-10858. doi: 10.1096/fj.201900730R. Epub 2019 Jul 5.
Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment.
Yoon S, Yi S, Rhee SJ, Lee HA, Kim Y, Yu KS, Chung JY
Transl Clin Pharmacol. 2019,Sep;27(3):107-114
Artificial intelligence in drug development: clinical pharmacologist perspective.
Jang IJ
Transl Clin Pharmacol 2019,Sep;27(3):87-88.
Safety, tolerability, and anti-tumor activity of olmutinib in non-small cell lung cancer with T790M mutation: A single arm, open label, phase 1/2 trial.
Kim DW, Lee DH, Han JY, Lee J, Cho BC, Kang JH, Lee KH, Cho EK, Kim JS, Min YJ, Cho JY, An HJ, Kim HG, Lee KH, Kim BS, Jang IJ, Yoon S, Han O, Noh YS, Hong KY, Park K
Lung Cancer 2019,Sep;135:66-72
Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population.
Lee S, Yoon S, Chung H, Ji SC, Yoon SH, Yu KS, Cho JY, Chung JY
Journal of clinical pharmacology 2019,Aug;59(8):1085-1092.
Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers.
Lee J, Yoon SH, Yi S, Kim AH, Kim B, Lee S, Yu KS, Jang IJ, Cho JY
Drug metabolism and pharmacokinetics 2019,Aug;34(4):247-252
Pharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under fasted and fed conditions in healthy volunteers.
Shin D, Park SI, Lee HS, An KM, Jung J, Lee M, Yu KS
Drug Des Devel Ther. 2019,Jul; 24;13:2483-2490
Pharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects.
Moon SJ, Jeon JY, Jang K, Yu KS, Lim Y, Kim MG
Drug Des Devel Ther. 2019,Jul;25;13:2533-2542
Use of Molecular Imaging in Clinical Drug Development: a Systematic Review.
Hyeomin Son, Kyungho Jang, Heechan Lee, Sang Eun Kim, Keon Wook kang, Howard lee
Nuclear medicine and molecular imaging 2019,Jun;53(3):208-215.
A First-in-Human Phase I Study of GC1118, a Novel Anti-Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors.
"DO-YOUN OH, KEUN-WOOK LEE, SAE-WON HAN, JIN WON KIM, JUNG-WON SHIN, SEONG-JIN JO, JONGHWA WON, SEOKYUNG HAHN, HOWARD LEE, WOO HO KIM, YUNG-JUE BANG"
The oncologist 2019,Jun; pii: theoncologist.2019-0294.
Challenges and insights of early oncology drug development in the Asia-Pacific region: introduction of phase I oncology clinical trial center and experience sharing for early clinical trials in Seoul National University Hospital, Korea.
Im SA, Lee DW, Kang R, Kim JH, Kim DW, Jang IJ, Lee JS, Bang YJ
Chin Clin Oncol 2019,Jun;8(3):27
Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients
Eun-Sook Park, Ah Ram Lee, Doo Hyun Kim, Jeong-Hoon Lee, Jeong-Ju Yoo 3, Sung Hyun Ahn, Heewoo Sim, Soree Park, Hong Seok Kang, Juhee Won, Yea Na Ha 1, Gu-Choul Shin 1, So Young Kwon 4, Yong Kwang Park 5, Byeong-Sun Choi, Yun Bin Lee, Nakcheol Jeong, Yohan An, Young Seok Ju,Su Jong Yu, Hee Bok Ch
J Hepatol . 2019,Jun; 2019 Jun;70(6):1093-1102. doi: 10.1016/j.jhep.2019.02.006. Epub 2019 Feb 20.
A Population Pharmacokinetic Study of Prophylactic Fluconazole in Preterm Infants for Prevention of Invasive Candidiasis
Kim YK, Lee J, Oh J, Rhee SJ, Shin SH, Yoon SH, Lee S, Kim HS, Yu KS
Antimicrobial agents and chemotherapy 2019,May;24;63(6).
URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers.
Rheumatology. 2019,May; pii: kez140.
Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry.
Kim JS, Kim AH, Jang C, Jang IJ, Kim KB, Cho JY, Hwang HY
Journal of Korean medical science 2019,Apr;8;34(13):e104.
Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
Dongseong Shin, Young Sil Eom, Suk Chon, Byung-Joon Kim, Kyung-Sang Yu, Dae Ho Lee
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019,Apr; 10;12:469-476.
Development of a Korean-specific virtual population for physiologically based pharmacokinetic modelling and simulation.
Yun Kim Oliver Hatley Su‐jin Rhee Sojeong Yi Hyun A. Lee Sumin Yoon Jae‐Yong Chung Kyung‐Sang Yu Howard Lee
Biopharmaceutics & drug disposition 2019,Apr;40(3-4):135-150.
A Rapid Method to Estimate Hepatocyte Loss Due to Drug-Induced Liver Injury.
Chung JY, Longo DM, Watkins PB
Clinical pharmacology and therapeutics 2019,Mar;105(3):746-753.
A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K+-competitive acid blocker.
Lee HA, Lee KR, Jang SB, Chung SY, Yu KS, HL
European journal of pharmaceutical sciences 2019,Mar;15;130:1-10.
Pharmacokinetics of fludarabine and its association with clinical outcomes in paediatric haematopoietic stem cell transplantation patients
Chung H, Hong KT, Lee JW, Rhee SJ, Kim S, Yoon SH, Yu KS, Kang HJ
Bone Marrow Transplant. 2019,Feb;2019 Feb;54(2):284-292. doi: 10.1038/s41409-018-0260-z. Epub 2018 Jun 18.
Pharmacokinetic characteristics and limited sampling strategies for therapeutic drug monitoring of colistin in patients with multidrug-resistant Gram-negative bacterial infections.
Kim EJ, Oh J, Lee K, Yu KS, Chung JY, Hwang JH, Nam EY, Kim HS, Kim M, Park JS, Song KH, Kim ES, Song J, Kim HB
Therapeutic drug monitoring 2019,Feb;41(1):102-106.
A Personalized CYP2C19 Phenotype-Guided Dosing Regimen of Voriconazole Using a Population Pharmacokinetic Analysis
Kim Y, Rhee SJ, Park WB, Yu KS, Jang IJ, Lee S
Journal of clinical medicine 2019,Feb;10;8(2).
AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway.
Tsogbadrakh B, Ryu H, Ju KD, Lee J, Yun S, Yu KS, Kim HJ, Ahn C, Oh KH
Biochemical and biophysical research communications 2019,Feb;12;509(3):680-686.
Pharmacokinetic comparison of gemigliptin 50 mg and metformin 500 mg as a fixed-dose combination and loose combination
Lee SW, Park SI, Lee S, Chung JY, Yu KS
International journal of clinical pharmacology and therapeutics 2019,Feb;57(2):117-124.
Ursodeoxycholic acid exerts hepatoprotective effects by regulating amino acid, flavonoid, and fatty acid metabolic pathways
Da Jung Kim , Hyewon Chung, Sang Chun Ji, SeungHwan Lee,Kyung‑Sang Yu, In‑Jin Jang, Joo‑Youn Cho
Metabolomics Society 2019,Feb;27;15(3):30.
Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia
Soo Young Moon, Ji-Hyun Lim, Eun-Hee Kim, Youngwon Nam, Kyung-Sang Yu, Kyung Taek Hong 3 4, Jung Yoon Choi, Che Ry Hong, Hyery Kim, Hyoung Jin Kang, Hee Young Shin, Kyunghoon Lee, Junghan Song, Soo-Youn Lee, Sang Hoon Song
Ther Drug Monit . 2019,Feb;2019 Feb;41(1):75-85. doi: 10.1097/FTD.0000000000000575.
. Comparison of the pharmacokinetic-pharmacodynamic relationships of two darbepoetin alfa formulations in healthy male volunteers.
Seokuee Kim, Taegon Hong, Jae-Wook Ko, Wooseong Huh, Jung-Ryul Kim
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2019,Feb;33(1):101-112. doi: 10.1007/s40259-018-0323-0.
What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing.
Polasek TM, Rostami-Hodjegan A, Yim DS, Jamei M, Lee H, Kimko H, Kim JK, Nguyen PTT, Darwich AS, Shin JG
The AAPS journal 2019,Jan;9;21(2):17.
Effect of cilostazol on the pharmacokinetics of simvastatin in healthy subjects.
Jung-Ryul Kim, Jin Ah Jung, Seokuee Kim, Wooseong Huh, Jong-Lyul Ghim, Jae-Gook Shin, Jae-Wook Ko
BioMed research international. 2019,Jan;9;2019:1365180. doi: 10.1155/2019/1365180. eCollection 2019.