SNUCPT

Pharmacodynamics and pharmacokinetics of DWP14012 (fexuprazan) in healthy subjects with different ethnicities

Jun Gi Hwang, Inseung Jeon, Sun Ae Park, Areum Lee, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Aliment Pharmacol Ther . 2020,Dec;52(11-12):1648-1657

Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects

Jung Sunwoo, Sang Chun Ji, Jaeseong Oh, Mu Seong Ban, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Aliment Pharmacol Ther . 2020,Dec;52(11-12):1640-1647

Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers

Sang Won Lee, Jaeseong Oh, Andrew HyoungJin Kim, Sang Chun Ji, Sang-In Park 4, Seo Hyun Yoon, Jae-Young Chung, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee

Pharmacogenomics J . 2020,Dec;20(6):792-800

Gut microorganisms and their metabolites modulate the severity of acute colitis in a tryptophan metabolism-dependent manner

Ji-Hee Shin , Young-Kwan Lee, Woo-Jeong Shon, Bora Kim, Che Ok Jeon, Joo-Youn Cho, Herbert C Morse 3rd, Eun Young Choi, Dong-Mi Shin

Eur J Nutr . 2020,Dec;59(8):3591-3601.

Electronic medical records-based comparison of glycemic control efficacy between sulfonylureas and dipeptidyl peptidase-4 inhibitors added on to metformin monotherapy in patients with type 2 diabetes

Suhrin Lee , SeungHwan Lee , In-Jin Jang , Kyung-Sang Yu , and Su-jin Rhee

Transl Clin Pharmacol . 2020,Dec;2020 Dec;28(4):199-207. doi: 10.12793/tcp.2020.28.e21. Epub 2020 Dec 18.

Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers

Yoon DY, Sunwoo J, Shin N, Kim AR, Kim B, Song GS, Jang IJ, Lee S.

Clin Transl Sci 2020,Dec;2020 Dec 31. doi: 10.1111/cts.12958. Online ahead of print.

Pharmacogenomic information from CPIC and DPWG guidelines and its application on drug labels

Yoon DY, Lee S, Ban MS, Jang IJ, Lee S.

Transl Clin Pharmacol 2020,Dec; 2020 Dec;28(4):189-198. doi: 10.12793/tcp.2020.28.e18. Epub 2020 Dec 11.

Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects

Hyounggyoon Yoo, Yun Kim, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug Des Devel Ther . 2020,Nov; 24;14:5179-5187

Multiple-dose pharmacokinetics and safety of amoxicillin/clavulanate in healthy elderly subjects

Sang Won Lee, Yewon Choi, Kyungho Jang, Seo Hyun Yoon, Jae-Yong Chung

Int J Clin Pharmacol Ther . 2020,Nov;58(11):634-641

Population Pharmacokinetic Analysis of Amikacin for Optimal Pharmacotherapy in Korean Patients with Nontuberculous Mycobacterial Pulmonary Disease

Xuanyou Jin, Jaeseong Oh, Joo-Youn Cho, SeungHwan Lee, Su-Jin Rhee

Antibiotics (Basel) . 2020,Nov;6;9(11):784

hIL-7-hyFc, A Long-Acting IL-7, Increased Absolute Lymphocyte Count in Healthy Subjects

Sang Won Lee, Donghoon Choi, MinKyu Heo, Eui-Cheol Shin, Su-Hyung Park, So Jeong Kim, Yeon-Kyung Oh, Byung Ha Lee , Se Hwan Yang, Young Chul Sung, Howard Lee

Clinical and translational science. 2020,Nov;2020 Nov;13(6):1161-1169. doi: 10.1111/cts.12800. Epub 2020 May 20.

Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects

Inyoung Hwang, Yun Kim, Hyounggyoon Yoo, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee

Drug Des Devel Ther . 2020,Oct;23;14:4493-4502

Pharmacokinetics and Tolerability of LC28-0126, a Novel Necrosis Inhibitor, After Multiple Ascending Doses: A Phase I Randomized, Double-blind, Placebo-controlled Study in Healthy Male Subjects

Eunwoo Kim, Inyoung Hwang, SeungHwan Lee, Jaeseong Oh, Hyewon Chung, Myungwon Jin, Soon Ha Kim, Kyung-Sang Yu

Clin Ther . 2020,Oct;42(10):1946-1954.e2

Development of a Pharmacokinetic Model Describing Neonatal Fc Receptor-Mediated Recycling of HL2351, a Novel Hybrid Fc-Fused Interleukin-1 Receptor Antagonist, to Optimize Dosage Regimen

Lien Ngo, Jaeseong Oh, Anhye Kim, Hyun-Moon Back, Won-Ho Kang, Jung-Woo Chae, Hwi-Yeol Yun, Howard Lee

CPT Pharmacometrics Syst Pharmacol . 2020,Oct;9(10):584-595

The Impact of COVID-19 on the Conduct of Clinical Trials for Medical Products in Korea

JuYeun Jeon, Hyeikyoung Kim, Kyung Sang Yu

J Korean Med Sci . 2020,Sep;14;35(36):e329

Phase I clinical trial of KML001 monotherapy in patients with advanced solid tumors.

Seokuee Kim, Sujong Kim, Young Suk Park, Joon Oh Park, Ho Yeong Lim, Jin Seok Ahn, Jeeyun Lee, Jong Mu Sun, Won Ki Kang, RaeO Han, Jungryul Kim, Myung-Ju Ahn

Expert opinion on investigational drugs. 2020,Sep;29(9):1059-1067. doi: 10.1080/13543784.2020.1804855. Epub 2020 Aug 29.

Impact of Vancomycin-Induced Changes in the Intestinal Microbiota on the Pharmacokinetics of Simvastatin

Jung Sunwoo, Sang Chun Ji, Andrew HyoungJin Kim, Kyung-Sang Yu, Joo-Youn Cho, In-Jin Jang, SeungHwan Lee

Clin Transl Sci . 2020,Jul;13(4):752-760

Usefulness of saliva for perampanel therapeutic drug monitoring

Do-Yong Kim, Jangsup Moon, Yong-Won Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, KaHeon Song, Kon Chu, Sangkun Lee

Epilepsia . 2020,Jun;61(6):1120-1128

Comparative pharmacokinetics of a montelukast/levocetirizine fixed-dose combination chewable tablet versus individual administration of montelukast and levocetirizine after a single oral administration in healthy Korean male subjects

Seol Ju Moon, Kyung-Sang Yu, Jina Jung, Yong-Il Kim, Min-Gul Kim

Int J Clin Pharmacol Ther . 2020,Jun;58(6):354-362.

An Assessment of Pharmacokinetic Interaction Between Lobeglitazone and Sitagliptin After Multiple Oral Administrations in Healthy Men

Seol Ju Moon, Kyung-Sang Yu, Min-Gul Kim

Clin Ther . 2020,Jun;42(6):1047-1057

Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A

Yujin Lee, Woori Chae, Seonghae Yoon, Jae-Yong Chung, Joo-Youn Cho

Transl Clin Pharmacol . 2020,Jun;28(2):73-82

Common data model-based real-world data for practical clinical practice guidelines: clinical pharmacology perspectives

Yoomin Jeon, Yoona Choi, Esther Hehsun Kim, SeonYeong Oh, Howard Lee

Translational and Clinical Pharmacology 2020,Jun;2020 Jun;28(2):67-72. doi: 10.12793/tcp.2020.28.e11. Epub 2020 Jun 25.

Pharmacokinetics of human antithrombin III concentrate in the immediate postoperative period after liver transplantation

Bo Rim Kim, Jaeseong Oh, Kyung-Sang Yu, Ho Geol Ryu

Br J Clin Pharmacol . 2020,May;86(5):923-932

Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets

Jun Gi Hwang, Kyung-Sang Yu, SeungHwan Lee

Drug Des Devel Ther . 2020,May;20;14:1953-1961

Author Response: Does the Fc Region Have a Role in the Ocular Half-Life After Intravitreal Injection?

Kwangsic Joo, Yewon Choi, Jae-Yong Chung, Se Joon Woo

Invest Ophthalmol Vis Sci . 2020,May;11;61(5):21

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Hyeong Min Kim, Seungmin Ha, Hye Kyoung Hong, Yoonha Hwang, Pilhan Kim 3 4 5, Eunsol Yang 6, Jae Yong Chung 6, Sunyoung Park, Young Joo Park, Kyu Hyung Park, Hyuncheol Kim, Se Joon Woo

Transl Vis Sci Technol . 2020,May;20;9(6):20.

External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old

Sang Hwan Ji, Ji Hyun Lee, Joo Youn Cho, Hwa Suk Kim, Young Eun Jang, Eun Hee Kim, Jin Tae Kim, Hee Soo Kim

J Korean Med Sci . 2020,May;2020 Mar 23;35(11):e70. doi: 10.3346/jkms.2020.35.e70.

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

Je-Hwan Lee, Stefan Faderl, John M Page, Chul Won Jung, Sung-Soo Yoon 5, Animesh D Pardanani 6, Pamela S Becker 7, Howard Lee, Jeongeun Choi, Kyoungjune Lee, Minkyoung Kim, Jorge E Cortes

Blood advances. 2020,May;2020 May 12;4(9):2032-2043. doi: 10.1182/bloodadvances.2019000757.

Phase I and pharmacokinetic study of the vascular-disrupting agent CKD-516 (NOV120401) in patients with refractory solid tumors

Hark Kyun Kim, Jeong Won Kang, Young-Whan Park, Jung Young Kim, Minchae Kim, Soo Jin Kim, Se-Mi Kim, Keun Ho Ryu, Seonghae Yoon, Yun Kim, Joo-Youn Cho, Keun Seok Lee, Tak Yun, Kiwon Kim, Mi Hyang Kwak, Tae-Sung Kim, Jinsoo Chung, Joong-Won Park

Pharmacol Res Perspect . 2020,Apr;8(2):e00568

Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis

Kyoung Hee Han, Bora Kim, Sang Chun Ji, Hee Gyung Kang, Hae Il Cheong, Joo-Youn Cho, Il-Soo Ha

Metabolites . 2020,Apr;24;10(4):169

A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli

Juha Song, Dohyun Han, Heonyi Lee, Da Jung Kim, Joo-Youn Cho, Jae-Hak Park, Seung Hyeok Seok

Int J Mol Sci . 2020,Apr;25;21(9):3037

Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea

Hee Kyung Kim, Su Mi Choi, Gaeun Kang, Kyung Hwa Park, Dong Gun Lee 3, Wan Beom Park, Su Jin Rhee, SeungHwan Lee, Sook In Jung, Hee Chang Jang

Yonsei Med J . 2020,Apr;61(4):301-309

A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMET TM Plus Platform

Jeong-An Gim, Yonghan Kwon, Hyun A Lee, Kyeong-Ryoon Lee, Soohyun Kim, Yoonjung Choi, Yu Kyong Kim, Howard Lee

Int J Mol Sci . 2020,Apr;2020 Apr 4;21(7):2517. doi: 10.3390/ijms21072517.

Pharmacokinetic and Safety Profiles of a Fixed‐Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3‐Period Replicate Crossover Study.

Seokuee Kim, Jae-Wook Ko, Jung-Ryul Kim

Clinical pharmacology in drug development. 2020,Apr;9(3):386-394. doi: 10.1002/cpdd.727. Epub 2019 Aug 2.

The road to biosimilars in rare diseases - ongoing lessons from Gaucher disease

Guillermo Drelichman, Gilberto Castañeda-Hernández, Muhlis Cem Ar, Marta Dragosky, Ricardo Garcia, Howard Lee, Sergey Moiseev, Majid Naderi, Hanna Rosenbaum, Ir Selena Freisens, Pramod K Mistryena Žnidar, Andrés Felipe Zuluaga,

Am J Hematol . 2020,Mar;95(3):233-237

Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans

Thi Lien Ngo, Chung-Hee Lee, Nayoung Han, Hyun-Moon Back, Su-Jin Rhee, Keumhan Noh, Hwi-Yeol Yun, Wonku Kang, Jung-Woo Chae

Int J Mol Sci . 2020,Mar; 9;21(5):1862

Pharmacokinetics and pharmacodynamics of a fixed-dose combination of gemigliptin/metformin sustained release 25/500 mg compared to the loose combination in healthy male subjects

Xuanyou Jin, Eunwoo Kim, Ki Young Huh, Inyoung Hwang, Joo-Youn Cho, Kyung-Sang Yu, SeungHwan Lee

Transl Clin Pharmacol . 2020,Mar;2020 Mar;28(1):43-54. doi: 10.12793/tcp.2020.28.e2. Epub 2020 Mar 30.

Altered Gene Expression Profiles in Peripheral Blood Mononuclear Cells in Obese Subjects

Kyungho Jang, Tao Tong, Jinhui Lee, Taesun Park, Howard Lee

Obesity facts. 2020,Mar;2020;13(3):375-385. doi: 10.1159/000507817. Epub 2020 Jun 16.

Intraocular Pharmacokinetics of 10-fold Intravitreal Ranibizumab Injection Dose in Rabbits

Hyeong Min Kim, Young Joo Park , Simin Lee, Joo Young Son, Hye Kyoung Hong, Min Hee Ham, Xuanyou Jin, Jae Yong Chung, Kyu Hyung Park, Ki Dong Park Se Joon Woo

Transl Vis Sci Technol . 2020,Mar;2020 Mar 9;9(4):7. doi: 10.1167/tvst.9.4.7. eCollection 2020 Mar.

Complex influences of gut microbiome metabolism on various drug responses

Sihyun Chae, Da Jung Kim, Joo-Youn Cho

Translational and clinical pharmacology. 2020,Mar;28(1):7-16. doi: 10.12793/tcp.2020.28.e3.

Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers.

Yoon DY, Park SI, Jung JA, Kim YI, Jang IJ, Chung JY.

Drug Des Devel Ther. 2020,Feb;19;14:661-668.

Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles.

Kim DJ, Yang J, Seo H, Lee WH, Ho Lee D, Kym S, Park YS, Kim JG, Jang IJ, Kim YK, Cho JY

Sci Rep 2020,Feb;18;10(1):2860

Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer's disease animal model

Hyunju Kim, Bora Kim, Hye-Sun Kim, Joo-Youn Cho

Mol Brain. 2020,Feb;7;13(1):17

Safety, tolerability and pharmacokinetics and pharmacodynamics of HL2351, a novel hybrid fc-fused interleukin-1 receptor antagonist, in healthy subjects: A first-in-human study

Jaeseong Oh, Ki Young Huh, Young-Gyu Cho, Ji-Eun Cha, Se-Jin Kim, Seo Hyun Yoon, Sung Sup Park, Hyunyee Yoon, Jieon Lee, Howard Lee

Br J Clin Pharmacol . 2020,Feb;86(2):372-379

Pharmacokinetics of high-dose carboplatin in children undergoing high-dose chemotherapy and autologous stem cell transplantation with BSA-based dosing

Che Ry Hong, Hyoung Jin Kang, Seol Ju Moon, Jaeseong Oh, Kyung Taek Hong, Jung Yoon Choi, Kyung-Sang Yu, Hee Young Shin

Bone Marrow Transplant . 2020,Jan;55(1):137-146

A Prediction Model for the Intraocular Pharmacokinetics of Intravitreally Injected Drugs Based on Molecular Physicochemical Properties

Hyeong Min Kim, Kyu Hyung Park, Jae Yong Chung, Se Joon Woo

Ophthalmic Res . 2020,Jan;63(1):41-49.

Human ADME for YH12852 using wavelength scanning cavity ring-down spectroscopy (WS-CRDS) after a low radioactivity dose

Anhye Kim, Stephen R Dueker, Feng Dong, Ad F Roffel, Sang-Won Lee, Howard Lee

BIOANALYSIS 2020,Jan;2020 Jan;12(2):87-98. doi: 10.4155/bio-2019-0119.